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[Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus].
Rinsho Shinkeigaku. 2006 May; 46(5):335-8.RS

Abstract

We report a 31-year-old patient who suffered from the left foot motor seizure since 6 years of age. In addition to spontaneous seizures, the seizures tended to be triggered by somatosensory stimulus to the left foot. Recently, he developed irregular myoclonic jerks of the left foot. Neurologically, he had mild impairment of fine movements of the left foot, but otherwise no weakness or sensory disturbance was noted. Interictal spikes were frequently recorded at the vertex region, where ictal discharges also started during the video-EEG monitoring. Electrical stimulation of the left tibial nerve evoked giant cortical components of somatosensory evoked potentials and C-reflex. Magnetoencephalographic study of both interictal and jerk-locked averaged spikes located the equivalent current dipole of both activities at the left foot primary somatosensory cortex (SI), where 3 tesla MRI revealed a focal abnormality consistent with focal cortical dysplasia. The present non-invasive investigation suggests that focal cortical dysplasia at SI could manifest intrinsic, autonomous, epileptogenicity as well as extrinsic, stimulus-sensitive, hyperexcitability, which are clinically manifested as spontaneous seizures and cortical reflex myoclonus, respectively.

Authors+Show Affiliations

Department of Neurology, Kyoto University Graduate School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

16886801

Citation

Nakagawa, Yasuko, et al. "[Focal Cortical Dysplasia at the Primary Somatosensory Cortex Could Manifest Both Intractable Partial Epilepsy and Cortical Reflex Myoclonus]." Rinsho Shinkeigaku = Clinical Neurology, vol. 46, no. 5, 2006, pp. 335-8.
Nakagawa Y, Matsumoto R, Ikeda A, et al. [Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus]. Rinsho Shinkeigaku. 2006;46(5):335-8.
Nakagawa, Y., Matsumoto, R., Ikeda, A., Mikuni, N., Matsuhashi, M., Hanakawa, T., Fukuyama, H., & Shimohama, S. (2006). [Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus]. Rinsho Shinkeigaku = Clinical Neurology, 46(5), 335-8.
Nakagawa Y, et al. [Focal Cortical Dysplasia at the Primary Somatosensory Cortex Could Manifest Both Intractable Partial Epilepsy and Cortical Reflex Myoclonus]. Rinsho Shinkeigaku. 2006;46(5):335-8. PubMed PMID: 16886801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus]. AU - Nakagawa,Yasuko, AU - Matsumoto,Riki, AU - Ikeda,Akio, AU - Mikuni,Nobuhiro, AU - Matsuhashi,Masao, AU - Hanakawa,Takashi, AU - Fukuyama,Hidenao, AU - Shimohama,Shun, PY - 2006/8/5/pubmed PY - 2006/10/18/medline PY - 2006/8/5/entrez SP - 335 EP - 8 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 46 IS - 5 N2 - We report a 31-year-old patient who suffered from the left foot motor seizure since 6 years of age. In addition to spontaneous seizures, the seizures tended to be triggered by somatosensory stimulus to the left foot. Recently, he developed irregular myoclonic jerks of the left foot. Neurologically, he had mild impairment of fine movements of the left foot, but otherwise no weakness or sensory disturbance was noted. Interictal spikes were frequently recorded at the vertex region, where ictal discharges also started during the video-EEG monitoring. Electrical stimulation of the left tibial nerve evoked giant cortical components of somatosensory evoked potentials and C-reflex. Magnetoencephalographic study of both interictal and jerk-locked averaged spikes located the equivalent current dipole of both activities at the left foot primary somatosensory cortex (SI), where 3 tesla MRI revealed a focal abnormality consistent with focal cortical dysplasia. The present non-invasive investigation suggests that focal cortical dysplasia at SI could manifest intrinsic, autonomous, epileptogenicity as well as extrinsic, stimulus-sensitive, hyperexcitability, which are clinically manifested as spontaneous seizures and cortical reflex myoclonus, respectively. SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/16886801/[Focal_cortical_dysplasia_at_the_primary_somatosensory_cortex_could_manifest_both_intractable_partial_epilepsy_and_cortical_reflex_myoclonus]_ L2 - http://www.diseaseinfosearch.org/result/5035 DB - PRIME DP - Unbound Medicine ER -