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Presentation and evolution of organic central precocious puberty according to the type of CNS lesion.
Clin Endocrinol (Oxf). 2006 Aug; 65(2):239-45.CE

Abstract

OBJECTIVE

To evaluate the influence of the type and treatment of CNS lesion causing central precocious puberty (CPP) on the presentation, hypothalamic-pituitary function and final height.

PATIENTS

One hundred patients with CPP caused by central nervous system (CNS) lesion.

RESULTS

The CPP was the presenting symptom of the lesion in 25 (10 boys) and occurred in 75 patients (23 boys) previously treated for lesions. These were optic glioma or astrocytoma (n = 45), hydrocephalus (n = 22), hypothalamic hamartoma (n = 15), suprasellar arachnoid cyst (n = 10) and others (n = 8). The percentages of patients with increased height, bone age advance, testicular volume, LH/FSH peaks ratio after gonadotrophin-releasing hormone (GnRH) test and plasma testosterone concentration in boys and oestradiol in girls varied from one aetiology to another. The boys with hamartoma were significantly taller and had greater bone age advance, LH peak and testosterone than boys with optic glioma. The girls with hamartoma and suprasellar arachnoid cyst were significantly younger and had greater LH peak than girls in the other groups. All patients treated for optic glioma had hypothalamic-pituitary deficiencies, including GH (100%), thyrotrophin (71.4%), corticotrophin (12.5%) and pubertal (34.3%) deficiencies. Sixty percent of those with suprasellar cysts lacked GH. Final height was below -2 SD in 15/59 (25%) patients, including 5/11 not treated with GnRH analogue, 3/5 not treated with GH despite GH deficiency, and 2 with hydrocephalus as a result of meningomyelocele.

CONCLUSIONS

The type of CNS lesion influences the presentation of CPP. This is probably caused by differences in the mechanisms inducing puberty and to the hypothalamic-pituitary deficiencies associated with the CPP as a result of a lesion and/or its treatment.

Authors+Show Affiliations

AP-HP, Hôpital Necker-Enfants Malades, Service d'Explorations Fonctionnelles, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16886967

Citation

Trivin, Christine, et al. "Presentation and Evolution of Organic Central Precocious Puberty According to the Type of CNS Lesion." Clinical Endocrinology, vol. 65, no. 2, 2006, pp. 239-45.
Trivin C, Couto-Silva AC, Sainte-Rose C, et al. Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin Endocrinol (Oxf). 2006;65(2):239-45.
Trivin, C., Couto-Silva, A. C., Sainte-Rose, C., Chemaitilly, W., Kalifa, C., Doz, F., Zerah, M., & Brauner, R. (2006). Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clinical Endocrinology, 65(2), 239-45.
Trivin C, et al. Presentation and Evolution of Organic Central Precocious Puberty According to the Type of CNS Lesion. Clin Endocrinol (Oxf). 2006;65(2):239-45. PubMed PMID: 16886967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. AU - Trivin,Christine, AU - Couto-Silva,Ana-Claudia, AU - Sainte-Rose,Christian, AU - Chemaitilly,Wassim, AU - Kalifa,Chantal, AU - Doz,François, AU - Zerah,Michel, AU - Brauner,Raja, PY - 2006/8/5/pubmed PY - 2006/12/9/medline PY - 2006/8/5/entrez SP - 239 EP - 45 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 65 IS - 2 N2 - OBJECTIVE: To evaluate the influence of the type and treatment of CNS lesion causing central precocious puberty (CPP) on the presentation, hypothalamic-pituitary function and final height. PATIENTS: One hundred patients with CPP caused by central nervous system (CNS) lesion. RESULTS: The CPP was the presenting symptom of the lesion in 25 (10 boys) and occurred in 75 patients (23 boys) previously treated for lesions. These were optic glioma or astrocytoma (n = 45), hydrocephalus (n = 22), hypothalamic hamartoma (n = 15), suprasellar arachnoid cyst (n = 10) and others (n = 8). The percentages of patients with increased height, bone age advance, testicular volume, LH/FSH peaks ratio after gonadotrophin-releasing hormone (GnRH) test and plasma testosterone concentration in boys and oestradiol in girls varied from one aetiology to another. The boys with hamartoma were significantly taller and had greater bone age advance, LH peak and testosterone than boys with optic glioma. The girls with hamartoma and suprasellar arachnoid cyst were significantly younger and had greater LH peak than girls in the other groups. All patients treated for optic glioma had hypothalamic-pituitary deficiencies, including GH (100%), thyrotrophin (71.4%), corticotrophin (12.5%) and pubertal (34.3%) deficiencies. Sixty percent of those with suprasellar cysts lacked GH. Final height was below -2 SD in 15/59 (25%) patients, including 5/11 not treated with GnRH analogue, 3/5 not treated with GH despite GH deficiency, and 2 with hydrocephalus as a result of meningomyelocele. CONCLUSIONS: The type of CNS lesion influences the presentation of CPP. This is probably caused by differences in the mechanisms inducing puberty and to the hypothalamic-pituitary deficiencies associated with the CPP as a result of a lesion and/or its treatment. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/16886967/Presentation_and_evolution_of_organic_central_precocious_puberty_according_to_the_type_of_CNS_lesion_ L2 - https://doi.org/10.1111/j.1365-2265.2006.02582.x DB - PRIME DP - Unbound Medicine ER -