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Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome.

Abstract

Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems play a role in the etiology of FMS. These polymorphisms are not specific for FMS and are associated with other functional somatic disorders and depression. Future genetic studies in the field of FMS and related conditions should be conducted in larger cohorts of patients and ethnically matched control groups.

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  • Authors+Show Affiliations

    ,

    Department of Medicine H, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel. dbuskila@bgumail.bgu.ac.il

    Source

    MeSH

    Catechol O-Methyltransferase
    Fibromyalgia
    Genetic Predisposition to Disease
    HLA Antigens
    Humans
    Receptor, Serotonin, 5-HT2A
    Serotonin Plasma Membrane Transport Proteins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    16887010

    Citation

    Buskila, Dan, and Piercarlo Sarzi-Puttini. "Biology and Therapy of Fibromyalgia. Genetic Aspects of Fibromyalgia Syndrome." Arthritis Research & Therapy, vol. 8, no. 5, 2006, p. 218.
    Buskila D, Sarzi-Puttini P. Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther. 2006;8(5):218.
    Buskila, D., & Sarzi-Puttini, P. (2006). Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Research & Therapy, 8(5), p. 218.
    Buskila D, Sarzi-Puttini P. Biology and Therapy of Fibromyalgia. Genetic Aspects of Fibromyalgia Syndrome. Arthritis Res Ther. 2006;8(5):218. PubMed PMID: 16887010.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. AU - Buskila,Dan, AU - Sarzi-Puttini,Piercarlo, PY - 2006/8/5/pubmed PY - 2007/2/10/medline PY - 2006/8/5/entrez SP - 218 EP - 218 JF - Arthritis research & therapy JO - Arthritis Res. Ther. VL - 8 IS - 5 N2 - Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems play a role in the etiology of FMS. These polymorphisms are not specific for FMS and are associated with other functional somatic disorders and depression. Future genetic studies in the field of FMS and related conditions should be conducted in larger cohorts of patients and ethnically matched control groups. SN - 1478-6362 UR - https://www.unboundmedicine.com/medline/citation/16887010/full_citation L2 - https://arthritis-research.biomedcentral.com/articles/10.1186/ar2005 DB - PRIME DP - Unbound Medicine ER -