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Ghrelin levels in young children with Prader-Willi syndrome.
J Pediatr. 2006 Aug; 149(2):199-204.JPed

Abstract

OBJECTIVE

To explore the hypothesis that high ghrelin levels contribute to obesity in Prader-Willi syndrome (PWS), we assessed whether the increased levels observed in older persons with PWS exist in very young children, before the onset of hyperphagia.

STUDY DESIGN

We measured ghrelin levels in nine children with PWS (17-60 months of age) and eight healthy control subjects of equivalent body mass index (BMI), age, and sex.

RESULTS

PWS and control groups had equivalent BMI (16.8 +/- 1.4 vs 16.1 +/- 0.9 kg/m(2), respectively; P = .24), age (37.8 +/- 15.4 vs 50.3 +/- 17.7 months; P = .14), and sex. PWS and control groups also had equivalent fasting levels of total ghrelin (787 +/- 242 vs 716 +/- 135 pg/mL, respectively; P = .24), bioactive ghrelin (102 +/- 35 vs 91 +/- 23 pg/mL; P = .45), insulin, and glucose. Ghrelin correlated negatively with BMI among controls (r = -0.760, P = .029) but not PWS (r = 0.015, P = .97).

CONCLUSIONS

Children <5 years of age with PWS, who had not yet developed hyperphagia or excessive obesity, had normal ghrelin levels, in contrast with the hyperghrelinemia of older, hyperphagic people with PWS. It is possible that ghrelin levels increase suddenly before hyperphagia develops.

Authors+Show Affiliations

Department of Pediatrics, Division of Developmental and Behavioral Pediatrics, Madigan Army Medical Center, Fort Lewis, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16887433

Citation

Erdie-Lalena, Christine R., et al. "Ghrelin Levels in Young Children With Prader-Willi Syndrome." The Journal of Pediatrics, vol. 149, no. 2, 2006, pp. 199-204.
Erdie-Lalena CR, Holm VA, Kelly PC, et al. Ghrelin levels in young children with Prader-Willi syndrome. J Pediatr. 2006;149(2):199-204.
Erdie-Lalena, C. R., Holm, V. A., Kelly, P. C., Frayo, R. S., & Cummings, D. E. (2006). Ghrelin levels in young children with Prader-Willi syndrome. The Journal of Pediatrics, 149(2), 199-204.
Erdie-Lalena CR, et al. Ghrelin Levels in Young Children With Prader-Willi Syndrome. J Pediatr. 2006;149(2):199-204. PubMed PMID: 16887433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin levels in young children with Prader-Willi syndrome. AU - Erdie-Lalena,Christine R, AU - Holm,Vanja A, AU - Kelly,Patrick C, AU - Frayo,R Scott, AU - Cummings,David E, PY - 2005/04/01/received PY - 2006/01/11/revised PY - 2006/04/13/accepted PY - 2006/8/5/pubmed PY - 2006/9/8/medline PY - 2006/8/5/entrez SP - 199 EP - 204 JF - The Journal of pediatrics JO - J. Pediatr. VL - 149 IS - 2 N2 - OBJECTIVE: To explore the hypothesis that high ghrelin levels contribute to obesity in Prader-Willi syndrome (PWS), we assessed whether the increased levels observed in older persons with PWS exist in very young children, before the onset of hyperphagia. STUDY DESIGN: We measured ghrelin levels in nine children with PWS (17-60 months of age) and eight healthy control subjects of equivalent body mass index (BMI), age, and sex. RESULTS: PWS and control groups had equivalent BMI (16.8 +/- 1.4 vs 16.1 +/- 0.9 kg/m(2), respectively; P = .24), age (37.8 +/- 15.4 vs 50.3 +/- 17.7 months; P = .14), and sex. PWS and control groups also had equivalent fasting levels of total ghrelin (787 +/- 242 vs 716 +/- 135 pg/mL, respectively; P = .24), bioactive ghrelin (102 +/- 35 vs 91 +/- 23 pg/mL; P = .45), insulin, and glucose. Ghrelin correlated negatively with BMI among controls (r = -0.760, P = .029) but not PWS (r = 0.015, P = .97). CONCLUSIONS: Children <5 years of age with PWS, who had not yet developed hyperphagia or excessive obesity, had normal ghrelin levels, in contrast with the hyperghrelinemia of older, hyperphagic people with PWS. It is possible that ghrelin levels increase suddenly before hyperphagia develops. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/16887433/Ghrelin_levels_in_young_children_with_Prader_Willi_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(06)00306-4 DB - PRIME DP - Unbound Medicine ER -