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Evaluation of gastroesophageal reflux in pediatric patients with asthma using impedance-pH monitoring.
J Pediatr 2006; 149(2):216-9JPed

Abstract

OBJECTIVES

To determine the proportion of acid and nonacid reflux events in children with asthma suspected to have gastroesophageal reflux (GER) using combined impedance-pH monitoring, and to determine the symptom index (SI) for nonacid and acid reflux events.

STUDY DESIGN

This was a prospective study of children with asthma (age 5 months to 6 years) referred for evaluation of GER. Exclusion criteria were congenital anomalies, cerebral palsy, mental retardation, and cardiac disease. The children underwent a 20-hour multichannel intraluminal impedance (MII)-pH study.

RESULTS

A total of 24 children (17 male; mean age, 33 months) were enrolled from March 2004 to February 2005. MII-pH detected 1184 reflux events, versus 419 reflux events by pH alone; 51% (605 events) were nonacid. The proportion of nonacid reflux events decreased with time elapsed from last meal (P < .0001 by Pearson's chi2 test). A total of 555 symptoms were recorded, including 331 cases of cough, 243 of which (73.4%) were not associated with a reflux event. The SI for MII-pH was significantly different than that for the pH probe (37% vs 0%; P = .008).

CONCLUSIONS

Acid and nonacid reflux occurs with equal frequency in children with asthma. Most symptoms occur in the absence of a reflux event.

Authors+Show Affiliations

Pediatric Gastroenterology, Hepatology, and Nutrition Section and the General Clinical Research Center, Department of Pediatrics, Children's Hospital, University of Colorado Health Sciences Center, Denver, Colorado, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16887437

Citation

Condino, Adria A., et al. "Evaluation of Gastroesophageal Reflux in Pediatric Patients With Asthma Using impedance-pH Monitoring." The Journal of Pediatrics, vol. 149, no. 2, 2006, pp. 216-9.
Condino AA, Sondheimer J, Pan Z, et al. Evaluation of gastroesophageal reflux in pediatric patients with asthma using impedance-pH monitoring. J Pediatr. 2006;149(2):216-9.
Condino, A. A., Sondheimer, J., Pan, Z., Gralla, J., Perry, D., & O'Connor, J. A. (2006). Evaluation of gastroesophageal reflux in pediatric patients with asthma using impedance-pH monitoring. The Journal of Pediatrics, 149(2), pp. 216-9.
Condino AA, et al. Evaluation of Gastroesophageal Reflux in Pediatric Patients With Asthma Using impedance-pH Monitoring. J Pediatr. 2006;149(2):216-9. PubMed PMID: 16887437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of gastroesophageal reflux in pediatric patients with asthma using impedance-pH monitoring. AU - Condino,Adria A, AU - Sondheimer,Judith, AU - Pan,Zhaoxing, AU - Gralla,Jane, AU - Perry,Darryl, AU - O'Connor,Judith A, PY - 2005/05/05/received PY - 2006/02/23/revised PY - 2006/03/09/accepted PY - 2006/8/5/pubmed PY - 2006/9/8/medline PY - 2006/8/5/entrez SP - 216 EP - 9 JF - The Journal of pediatrics JO - J. Pediatr. VL - 149 IS - 2 N2 - OBJECTIVES: To determine the proportion of acid and nonacid reflux events in children with asthma suspected to have gastroesophageal reflux (GER) using combined impedance-pH monitoring, and to determine the symptom index (SI) for nonacid and acid reflux events. STUDY DESIGN: This was a prospective study of children with asthma (age 5 months to 6 years) referred for evaluation of GER. Exclusion criteria were congenital anomalies, cerebral palsy, mental retardation, and cardiac disease. The children underwent a 20-hour multichannel intraluminal impedance (MII)-pH study. RESULTS: A total of 24 children (17 male; mean age, 33 months) were enrolled from March 2004 to February 2005. MII-pH detected 1184 reflux events, versus 419 reflux events by pH alone; 51% (605 events) were nonacid. The proportion of nonacid reflux events decreased with time elapsed from last meal (P < .0001 by Pearson's chi2 test). A total of 555 symptoms were recorded, including 331 cases of cough, 243 of which (73.4%) were not associated with a reflux event. The SI for MII-pH was significantly different than that for the pH probe (37% vs 0%; P = .008). CONCLUSIONS: Acid and nonacid reflux occurs with equal frequency in children with asthma. Most symptoms occur in the absence of a reflux event. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/16887437/Evaluation_of_gastroesophageal_reflux_in_pediatric_patients_with_asthma_using_impedance_pH_monitoring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(06)00207-1 DB - PRIME DP - Unbound Medicine ER -