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Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production.
Toxicol Appl Pharmacol. 2006 Nov 01; 216(3):479-84.TA

Abstract

In this study, we investigated the effect of the aqueous extract of Mosla dianthera (Maxim.) (AEMD) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as asthma, sinusitis and rheumatoid arthritis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. AEMD inhibited compound 48/80-induced systemic reactions in mice. AEMD decreased immunoglobulin E-mediated local allergic reactions, passive cutaneous anaphylaxis. AEMD attenuated intracellular calcium level and release of histamine from rat peritoneal mast cells activated by compound 48/80. Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells. The inhibitory effect of AEMD on the pro-inflammatory cytokines was nuclear factor-kappaB (NF-kappaB) dependent. AEMD decreased PMA and A23187-induced degradation of IkappaBalpha and nuclear translocation of NF-kappaB. Our findings provide evidence that AEMD inhibits mast cell-derived immediate-type allergic reactions and involvement of pro-inflammatory cytokines and NF-kappaB in these effects.

Authors+Show Affiliations

College of Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16890260

Citation

Lee, Dong-Hee, et al. "Mosla Dianthera Inhibits Mast Cell-mediated Allergic Reactions Through the Inhibition of Histamine Release and Inflammatory Cytokine Production." Toxicology and Applied Pharmacology, vol. 216, no. 3, 2006, pp. 479-84.
Lee DH, Kim SH, Eun JS, et al. Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. Toxicol Appl Pharmacol. 2006;216(3):479-84.
Lee, D. H., Kim, S. H., Eun, J. S., & Shin, T. Y. (2006). Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. Toxicology and Applied Pharmacology, 216(3), 479-84.
Lee DH, et al. Mosla Dianthera Inhibits Mast Cell-mediated Allergic Reactions Through the Inhibition of Histamine Release and Inflammatory Cytokine Production. Toxicol Appl Pharmacol. 2006 Nov 1;216(3):479-84. PubMed PMID: 16890260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. AU - Lee,Dong-Hee, AU - Kim,Sang-Hyun, AU - Eun,Jae-Soon, AU - Shin,Tae-Yong, Y1 - 2006/06/22/ PY - 2006/03/26/received PY - 2006/06/14/revised PY - 2006/06/14/accepted PY - 2006/8/8/pubmed PY - 2006/12/9/medline PY - 2006/8/8/entrez SP - 479 EP - 84 JF - Toxicology and applied pharmacology JO - Toxicol Appl Pharmacol VL - 216 IS - 3 N2 - In this study, we investigated the effect of the aqueous extract of Mosla dianthera (Maxim.) (AEMD) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as asthma, sinusitis and rheumatoid arthritis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. AEMD inhibited compound 48/80-induced systemic reactions in mice. AEMD decreased immunoglobulin E-mediated local allergic reactions, passive cutaneous anaphylaxis. AEMD attenuated intracellular calcium level and release of histamine from rat peritoneal mast cells activated by compound 48/80. Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells. The inhibitory effect of AEMD on the pro-inflammatory cytokines was nuclear factor-kappaB (NF-kappaB) dependent. AEMD decreased PMA and A23187-induced degradation of IkappaBalpha and nuclear translocation of NF-kappaB. Our findings provide evidence that AEMD inhibits mast cell-derived immediate-type allergic reactions and involvement of pro-inflammatory cytokines and NF-kappaB in these effects. SN - 0041-008X UR - https://www.unboundmedicine.com/medline/citation/16890260/Mosla_dianthera_inhibits_mast_cell_mediated_allergic_reactions_through_the_inhibition_of_histamine_release_and_inflammatory_cytokine_production_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-008X(06)00217-1 DB - PRIME DP - Unbound Medicine ER -