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Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients.
Psychoneuroendocrinology. 2006 Sep; 31(8):1019-25.P

Abstract

Data suggest that both neurotrophic and hypothalamic-pituitary-adrenocortical (HPA) systems are involved in the pathophysiology of depression. The aim of the present study was to investigate whether the non-conservative brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has an impact on HPA axis activity in depressed patients. At admission, the dexamethasone/CRH (DEX/CRH) test was performed in 187 drug-free in-patients suffering from major depression or depressed state of bipolar disorder (DSM-IV criteria). Moreover, genotyping of BDNF Val66Met polymorphism was carried out using the fluorescence resonance energy transfer method (FRET). Homozygous carriers of the Met/Met genotype showed a significantly higher HPA axis activity during the DEX/CRH test than patients carrying the Val/Val or Val/Met genotype (ACTH, cortisol). Our results further contribute to the hypothesized association between HPA axis dysregulation and reduced neuroplasticity in depression and are consistent with the assumption that BDNF is a stress-responsive intercellular messenger modifying HPA axis activity.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Nussbaumstr. 7, 80336 Munich, Germany. Cornelius.Schuele@med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16890377

Citation

Schüle, Cornelius, et al. "Brain-derived Neurotrophic Factor Val66Met Polymorphism and dexamethasone/CRH Test Results in Depressed Patients." Psychoneuroendocrinology, vol. 31, no. 8, 2006, pp. 1019-25.
Schüle C, Zill P, Baghai TC, et al. Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology. 2006;31(8):1019-25.
Schüle, C., Zill, P., Baghai, T. C., Eser, D., Zwanzger, P., Wenig, N., Rupprecht, R., & Bondy, B. (2006). Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology, 31(8), 1019-25.
Schüle C, et al. Brain-derived Neurotrophic Factor Val66Met Polymorphism and dexamethasone/CRH Test Results in Depressed Patients. Psychoneuroendocrinology. 2006;31(8):1019-25. PubMed PMID: 16890377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. AU - Schüle,Cornelius, AU - Zill,Peter, AU - Baghai,Thomas C, AU - Eser,Daniela, AU - Zwanzger,Peter, AU - Wenig,Nadine, AU - Rupprecht,Rainer, AU - Bondy,Brigitta, PY - 2006/04/11/received PY - 2006/06/14/revised PY - 2006/06/20/accepted PY - 2006/8/8/pubmed PY - 2006/10/13/medline PY - 2006/8/8/entrez SP - 1019 EP - 25 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 31 IS - 8 N2 - Data suggest that both neurotrophic and hypothalamic-pituitary-adrenocortical (HPA) systems are involved in the pathophysiology of depression. The aim of the present study was to investigate whether the non-conservative brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has an impact on HPA axis activity in depressed patients. At admission, the dexamethasone/CRH (DEX/CRH) test was performed in 187 drug-free in-patients suffering from major depression or depressed state of bipolar disorder (DSM-IV criteria). Moreover, genotyping of BDNF Val66Met polymorphism was carried out using the fluorescence resonance energy transfer method (FRET). Homozygous carriers of the Met/Met genotype showed a significantly higher HPA axis activity during the DEX/CRH test than patients carrying the Val/Val or Val/Met genotype (ACTH, cortisol). Our results further contribute to the hypothesized association between HPA axis dysregulation and reduced neuroplasticity in depression and are consistent with the assumption that BDNF is a stress-responsive intercellular messenger modifying HPA axis activity. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/16890377/Brain_derived_neurotrophic_factor_Val66Met_polymorphism_and_dexamethasone/CRH_test_results_in_depressed_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(06)00112-0 DB - PRIME DP - Unbound Medicine ER -