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The research of molecular and ionic mechanisms in vagally mediated atrial fibrillation in canine.
Int J Cardiol. 2007 May 02; 117(3):425-6.IJ

Abstract

BACKGROUND

The reentrant mechanism of vagally mediated AF is not clearly elucidated.

METHODS AND RESULTS

After vagal stimulation, thirty dogs were divided AF group (AF could be induced) and control group (AF could not be induced). Western blot and patch clamp were used to determine M(2) receptor and I(K,ACh) in left atrial appendage (LAA), right atrial appendage (RAA), left atrium (LA), right atrium (RA), pulmonary veins (PVs) and superior vena cava (SVC). In control group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. However, there was no significant difference in LAA, RAA and LA. In AF group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. Furthermore, the densities of the M(2) and I(K,ACh) in LAA and RAA were higher than that in LA.

CONCLUSIONS

Atrial appendage perhaps play an important role in initiation of cholinergic AF. However, PVs and SVC less often play an important role in vagotonic paroxysmal AF.

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Authors

Zhao QY
No affiliation info available
Huang CX
No affiliation info available
Jiang H
No affiliation info available
Yang B
No affiliation info available
Liang JJ
No affiliation info available
Chen H
No affiliation info available
Li GS
No affiliation info available

MeSH

AnimalsAtrial FibrillationDogsElectric StimulationIonsMolecular BiologyVagus Nerve

Pub Type(s)

Letter

Language

eng

PubMed ID

16891019

Citation

Zhao, Qing-Yan, et al. "The Research of Molecular and Ionic Mechanisms in Vagally Mediated Atrial Fibrillation in Canine." International Journal of Cardiology, vol. 117, no. 3, 2007, pp. 425-6.
Zhao QY, Huang CX, Jiang H, et al. The research of molecular and ionic mechanisms in vagally mediated atrial fibrillation in canine. Int J Cardiol. 2007;117(3):425-6.
Zhao, Q. Y., Huang, C. X., Jiang, H., Yang, B., Liang, J. J., Chen, H., & Li, G. S. (2007). The research of molecular and ionic mechanisms in vagally mediated atrial fibrillation in canine. International Journal of Cardiology, 117(3), 425-6.
Zhao QY, et al. The Research of Molecular and Ionic Mechanisms in Vagally Mediated Atrial Fibrillation in Canine. Int J Cardiol. 2007 May 2;117(3):425-6. PubMed PMID: 16891019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The research of molecular and ionic mechanisms in vagally mediated atrial fibrillation in canine. AU - Zhao,Qing-Yan, AU - Huang,Cong-Xin, AU - Jiang,Hong, AU - Yang,Bo, AU - Liang,Jin-Jun, AU - Chen,Hui, AU - Li,Geng-Shan, Y1 - 2006/08/04/ PY - 2006/05/19/received PY - 2006/05/27/accepted PY - 2006/8/8/pubmed PY - 2007/7/10/medline PY - 2006/8/8/entrez SP - 425 EP - 6 JF - International journal of cardiology JO - Int J Cardiol VL - 117 IS - 3 N2 - BACKGROUND: The reentrant mechanism of vagally mediated AF is not clearly elucidated. METHODS AND RESULTS: After vagal stimulation, thirty dogs were divided AF group (AF could be induced) and control group (AF could not be induced). Western blot and patch clamp were used to determine M(2) receptor and I(K,ACh) in left atrial appendage (LAA), right atrial appendage (RAA), left atrium (LA), right atrium (RA), pulmonary veins (PVs) and superior vena cava (SVC). In control group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. However, there was no significant difference in LAA, RAA and LA. In AF group, the densities of M(2) receptor and I(K,ACh) in LAA, RAA and LA were higher than that in RA, PVs and SVC. Furthermore, the densities of the M(2) and I(K,ACh) in LAA and RAA were higher than that in LA. CONCLUSIONS: Atrial appendage perhaps play an important role in initiation of cholinergic AF. However, PVs and SVC less often play an important role in vagotonic paroxysmal AF. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/16891019/The_research_of_molecular_and_ionic_mechanisms_in_vagally_mediated_atrial_fibrillation_in_canine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(06)00651-6 DB - PRIME DP - Unbound Medicine ER -