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Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision.
Am J Clin Pathol. 2006 Aug; 126(2):310-3.AJ

Abstract

To address the significance of lobular neoplasia (LN) in breast core needle biopsy specimens, we prospectively obtained LN cases and correlated results of subsequent tissue sampling. LN was diagnosed by core needle biopsy in 467 women; in 101 (21.6%), invasive carcinoma (IC) or ductal carcinoma in situ (DCIS) was diagnosed concurrently. Two patients (0.4%) had previous diagnoses of IC or DCIS, and 17 (3.6%) had a concurrent diagnosis of contralateral IC or DCIS. Of 366 patients without a concurrent diagnosis of IC or DCIS, subsequent tissue diagnoses were available for 156 cases (42.6%). Of 60 cases of LN and atypical ductal hyperplasia on the biopsy, 5 had IC and 10 had DCIS on the excision (total, 25%). Of 4 women with LN and a mucocele-like lesion on the biopsy, none had IC or DCIS on excision. Of 92 with LN alone on the biopsy, 7 had IC (6) or DCIS (1) on excision. Two cases were in sites away from the biopsy site, 3 in subsequent excisions of the biopsy site, and 2 after previous excision of the biopsy site without finding IC or DCIS. Although LN is associated with a high overall rate of IC and DCIS (30%), excision of the biopsy site for women with LN alone on core needle biopsy has a very low rate of IC and DCIS in our center. Women in whom biopsy sites are excised are still at risk for subsequent DCIS and IC.

Authors+Show Affiliations

Department of Pathology, Baptist Hospital of Miami, Miami, FL 33176, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16891208

Citation

Renshaw, Andrew A., et al. "Lobular Neoplasia in Breast Core Needle Biopsy Specimens Is Associated With a Low Risk of Ductal Carcinoma in Situ or Invasive Carcinoma On Subsequent Excision." American Journal of Clinical Pathology, vol. 126, no. 2, 2006, pp. 310-3.
Renshaw AA, Derhagopian RP, Martinez P, et al. Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision. Am J Clin Pathol. 2006;126(2):310-3.
Renshaw, A. A., Derhagopian, R. P., Martinez, P., & Gould, E. W. (2006). Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision. American Journal of Clinical Pathology, 126(2), 310-3.
Renshaw AA, et al. Lobular Neoplasia in Breast Core Needle Biopsy Specimens Is Associated With a Low Risk of Ductal Carcinoma in Situ or Invasive Carcinoma On Subsequent Excision. Am J Clin Pathol. 2006;126(2):310-3. PubMed PMID: 16891208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lobular neoplasia in breast core needle biopsy specimens is associated with a low risk of ductal carcinoma in situ or invasive carcinoma on subsequent excision. AU - Renshaw,Andrew A, AU - Derhagopian,Robert P, AU - Martinez,Pilar, AU - Gould,Edwin W, PY - 2006/8/8/pubmed PY - 2006/8/23/medline PY - 2006/8/8/entrez SP - 310 EP - 3 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 126 IS - 2 N2 - To address the significance of lobular neoplasia (LN) in breast core needle biopsy specimens, we prospectively obtained LN cases and correlated results of subsequent tissue sampling. LN was diagnosed by core needle biopsy in 467 women; in 101 (21.6%), invasive carcinoma (IC) or ductal carcinoma in situ (DCIS) was diagnosed concurrently. Two patients (0.4%) had previous diagnoses of IC or DCIS, and 17 (3.6%) had a concurrent diagnosis of contralateral IC or DCIS. Of 366 patients without a concurrent diagnosis of IC or DCIS, subsequent tissue diagnoses were available for 156 cases (42.6%). Of 60 cases of LN and atypical ductal hyperplasia on the biopsy, 5 had IC and 10 had DCIS on the excision (total, 25%). Of 4 women with LN and a mucocele-like lesion on the biopsy, none had IC or DCIS on excision. Of 92 with LN alone on the biopsy, 7 had IC (6) or DCIS (1) on excision. Two cases were in sites away from the biopsy site, 3 in subsequent excisions of the biopsy site, and 2 after previous excision of the biopsy site without finding IC or DCIS. Although LN is associated with a high overall rate of IC and DCIS (30%), excision of the biopsy site for women with LN alone on core needle biopsy has a very low rate of IC and DCIS in our center. Women in whom biopsy sites are excised are still at risk for subsequent DCIS and IC. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/16891208/Lobular_neoplasia_in_breast_core_needle_biopsy_specimens_is_associated_with_a_low_risk_of_ductal_carcinoma_in_situ_or_invasive_carcinoma_on_subsequent_excision_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/GT45-3DBM-LRNP-NKL2 DB - PRIME DP - Unbound Medicine ER -