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A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.

Abstract

Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with many characteristic features, including hyperandrogenaemia, insulin resistance and obesity which may have significant implications for pregnancy outcomes and long-term health of the woman. This meta-analysis was conducted to evaluate the risk of pregnancy and neonatal complications in women with PCOS. Electronic databases were searched for the following MeSH headings: PCOS, hyperandrogenism, pregnancy outcome, pregnancy complications, diabetes mellitus, type II. A handsearch of human reproduction and fertility and sterility was also conducted. Studies in which pregnancy outcomes in women with PCOS were compared with controls were considered for inclusion in this meta-analysis. Fifteen of 525 identified studies were included, involving 720 women presenting with PCOS and 4505 controls. Women with PCOS demonstrated a significantly higher risk of developing gestational diabetes [odds ratio (OR) 2.94; 95% confidence interval (CI): 1.70-5.08], pregnancy-induced hypertension (OR 3.67; 95% CI: 1.98-6.81), pre-eclampsia (OR 3.47; 95% CI: 1.95-6.17) and preterm birth (OR 1.75; 95% CI: 1.16-2.62). Their babies had a significantly higher risk of admission to a neonatal intensive care unit (OR 2.31; 95% CI: 1.25-4.26) and a higher perinatal mortality (OR 3.07; 95% CI: 1.03-9.21), unrelated to multiple births. In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications. Pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks.

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  • Authors+Show Affiliations

    ,

    Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Utrecht, The Netherlands. c.m.boomsma@umcutrecht.nl

    , , , ,

    Source

    MeSH

    Birth Weight
    Cesarean Section
    Diabetes, Gestational
    Female
    Humans
    Hypertension, Pregnancy-Induced
    Infant Mortality
    Infant, Newborn
    Infertility, Female
    Polycystic Ovary Syndrome
    Pre-Eclampsia
    Pregnancy
    Pregnancy Complications
    Pregnancy Outcome
    Premature Birth

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    16891296

    Citation

    Boomsma, C M., et al. "A Meta-analysis of Pregnancy Outcomes in Women With Polycystic Ovary Syndrome." Human Reproduction Update, vol. 12, no. 6, 2006, pp. 673-83.
    Boomsma CM, Eijkemans MJ, Hughes EG, et al. A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Hum Reprod Update. 2006;12(6):673-83.
    Boomsma, C. M., Eijkemans, M. J., Hughes, E. G., Visser, G. H., Fauser, B. C., & Macklon, N. S. (2006). A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. Human Reproduction Update, 12(6), pp. 673-83.
    Boomsma CM, et al. A Meta-analysis of Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. Hum Reprod Update. 2006;12(6):673-83. PubMed PMID: 16891296.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome. AU - Boomsma,C M, AU - Eijkemans,M J C, AU - Hughes,E G, AU - Visser,G H A, AU - Fauser,B C J M, AU - Macklon,N S, Y1 - 2006/08/04/ PY - 2006/8/8/pubmed PY - 2006/12/16/medline PY - 2006/8/8/entrez SP - 673 EP - 83 JF - Human reproduction update JO - Hum. Reprod. Update VL - 12 IS - 6 N2 - Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with many characteristic features, including hyperandrogenaemia, insulin resistance and obesity which may have significant implications for pregnancy outcomes and long-term health of the woman. This meta-analysis was conducted to evaluate the risk of pregnancy and neonatal complications in women with PCOS. Electronic databases were searched for the following MeSH headings: PCOS, hyperandrogenism, pregnancy outcome, pregnancy complications, diabetes mellitus, type II. A handsearch of human reproduction and fertility and sterility was also conducted. Studies in which pregnancy outcomes in women with PCOS were compared with controls were considered for inclusion in this meta-analysis. Fifteen of 525 identified studies were included, involving 720 women presenting with PCOS and 4505 controls. Women with PCOS demonstrated a significantly higher risk of developing gestational diabetes [odds ratio (OR) 2.94; 95% confidence interval (CI): 1.70-5.08], pregnancy-induced hypertension (OR 3.67; 95% CI: 1.98-6.81), pre-eclampsia (OR 3.47; 95% CI: 1.95-6.17) and preterm birth (OR 1.75; 95% CI: 1.16-2.62). Their babies had a significantly higher risk of admission to a neonatal intensive care unit (OR 2.31; 95% CI: 1.25-4.26) and a higher perinatal mortality (OR 3.07; 95% CI: 1.03-9.21), unrelated to multiple births. In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications. Pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks. SN - 1355-4786 UR - https://www.unboundmedicine.com/medline/citation/16891296/A_meta_analysis_of_pregnancy_outcomes_in_women_with_polycystic_ovary_syndrome_ L2 - https://academic.oup.com/humupd/article-lookup/doi/10.1093/humupd/dml036 DB - PRIME DP - Unbound Medicine ER -