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Pharmacotherapeutic treatment of nightmares and insomnia in posttraumatic stress disorder: an overview of the literature.
Ann N Y Acad Sci 2006; 1071:502-7AN

Abstract

Sleep disturbances are hallmark symptoms of posttraumatic stress disorder (PTSD). Where the subjective experience of nightmares and insomnia in PTSD patients is very real indeed and demands treatment, objective research findings on disordered sleep architecture in PTSD are inconclusive and inconsistent. After reviewing the literature an insufficient number of controlled studies are published to formulate evidence-based guidelines. Several studies have methodological limitations, such as small group sizes and heterogenic samples. Large randomized controlled trials (RCTs) need to be conducted in order to further develop adequate therapeutic interventions. Objective parameters for insomnia and nightmares need to be identified for understanding underlying mechanisms of disturbed sleep in PTSD, and for evaluating therapy.

Authors+Show Affiliations

Rudolf Magnus Institute of Neurosciences and Department of Military Psychiatry, Central Military Hospital, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16891608

Citation

van Liempt, Saskia, et al. "Pharmacotherapeutic Treatment of Nightmares and Insomnia in Posttraumatic Stress Disorder: an Overview of the Literature." Annals of the New York Academy of Sciences, vol. 1071, 2006, pp. 502-7.
van Liempt S, Vermetten E, Geuze E, et al. Pharmacotherapeutic treatment of nightmares and insomnia in posttraumatic stress disorder: an overview of the literature. Ann N Y Acad Sci. 2006;1071:502-7.
van Liempt, S., Vermetten, E., Geuze, E., & Westenberg, H. (2006). Pharmacotherapeutic treatment of nightmares and insomnia in posttraumatic stress disorder: an overview of the literature. Annals of the New York Academy of Sciences, 1071, pp. 502-7.
van Liempt S, et al. Pharmacotherapeutic Treatment of Nightmares and Insomnia in Posttraumatic Stress Disorder: an Overview of the Literature. Ann N Y Acad Sci. 2006;1071:502-7. PubMed PMID: 16891608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacotherapeutic treatment of nightmares and insomnia in posttraumatic stress disorder: an overview of the literature. AU - van Liempt,Saskia, AU - Vermetten,Eric, AU - Geuze,Elbert, AU - Westenberg,Herman, PY - 2006/8/8/pubmed PY - 2006/9/21/medline PY - 2006/8/8/entrez SP - 502 EP - 7 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1071 N2 - Sleep disturbances are hallmark symptoms of posttraumatic stress disorder (PTSD). Where the subjective experience of nightmares and insomnia in PTSD patients is very real indeed and demands treatment, objective research findings on disordered sleep architecture in PTSD are inconclusive and inconsistent. After reviewing the literature an insufficient number of controlled studies are published to formulate evidence-based guidelines. Several studies have methodological limitations, such as small group sizes and heterogenic samples. Large randomized controlled trials (RCTs) need to be conducted in order to further develop adequate therapeutic interventions. Objective parameters for insomnia and nightmares need to be identified for understanding underlying mechanisms of disturbed sleep in PTSD, and for evaluating therapy. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/16891608/Pharmacotherapeutic_treatment_of_nightmares_and_insomnia_in_posttraumatic_stress_disorder:_an_overview_of_the_literature_ L2 - https://doi.org/10.1196/annals.1364.053 DB - PRIME DP - Unbound Medicine ER -