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Atypical pathogens as etiologic agents in hospitalized patients with community-acquired pneumonia in Korea: a prospective multi-center study.
J Korean Med Sci. 2006 Aug; 21(4):602-7.JK

Abstract

Local epidemiologic data on the etiologies of patients hospitalized with community-acquired pneumonia (CAP) is needed to develop guidelines for clinical practice. This study was conducted prospectively to determine the proportion of atypical bacterial pathogens in adults patients hospitalized with CAP in Korea between October 2001 and December 2002. Microbiological diagnosis was determined by serology for antibodies to Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila. Nucleic acid of M. pneumoniae and C. pneumoniae in respiratory samples and Legionella antigen in urine samples were detected. The study population consisted of 126 patients (71 males, 55 females), averaging 54.6 yr (SD+/-17.8), whose paired sera were available. An etiologic diagnosis for atypical pathogens was made in 18 patients (14.3%): C. pneumoniae 9 (7.1%), M. pneumoniae 8 (6.3%), and L. pneumophila 3 patients (2.4%). Streptococcus preumoniae and other typical pathogens were isolated from 36 patients (28.6%). Of 126 patients, 16 (12.7%) were admitted to intensive care unit and atypical pathogens were identified in 5 patients (31.3%). Initial clinical features of patients with pneumonia due to atypical, typical or undetermined pathogens were indistinguishable. We conclude that atypical pathogens should be seriously considered in hospitalized patients with CAP, when initiating empiric treatment in Korea.

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Authors+Show Affiliations

Sohn JW
Department of Internal Medicine, Korea University College of Medicine, Seongbuk-gu, Seoul, Korea.
Park SC
No affiliation info available
Choi YH
No affiliation info available
Woo HJ
No affiliation info available
Cho YK
No affiliation info available
Lee JS
No affiliation info available
Sim HS
No affiliation info available
Kim MJ
No affiliation info available

MeSH

AdultAgedAntibodies, BacterialAntigens, BacterialChlamydophila pneumoniaeCommunity-Acquired InfectionsFemaleHospitalizationHumansKoreaLegionella pneumophilaMaleMiddle AgedMycoplasma pneumoniaePneumonia, BacterialPolymerase Chain ReactionProspective StudiesRNA, Ribosomal, 16S

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16891800

Citation

Sohn, Jang Wook, et al. "Atypical Pathogens as Etiologic Agents in Hospitalized Patients With Community-acquired Pneumonia in Korea: a Prospective Multi-center Study." Journal of Korean Medical Science, vol. 21, no. 4, 2006, pp. 602-7.
Sohn JW, Park SC, Choi YH, et al. Atypical pathogens as etiologic agents in hospitalized patients with community-acquired pneumonia in Korea: a prospective multi-center study. J Korean Med Sci. 2006;21(4):602-7.
Sohn, J. W., Park, S. C., Choi, Y. H., Woo, H. J., Cho, Y. K., Lee, J. S., Sim, H. S., & Kim, M. J. (2006). Atypical pathogens as etiologic agents in hospitalized patients with community-acquired pneumonia in Korea: a prospective multi-center study. Journal of Korean Medical Science, 21(4), 602-7.
Sohn JW, et al. Atypical Pathogens as Etiologic Agents in Hospitalized Patients With Community-acquired Pneumonia in Korea: a Prospective Multi-center Study. J Korean Med Sci. 2006;21(4):602-7. PubMed PMID: 16891800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical pathogens as etiologic agents in hospitalized patients with community-acquired pneumonia in Korea: a prospective multi-center study. AU - Sohn,Jang Wook, AU - Park,Seung Chul, AU - Choi,Young-Hwa, AU - Woo,Heung Jeong, AU - Cho,Yong Kyun, AU - Lee,Jin Soo, AU - Sim,Hee-Sun, AU - Kim,Min Ja, PY - 2006/8/8/pubmed PY - 2006/10/20/medline PY - 2006/8/8/entrez SP - 602 EP - 7 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 21 IS - 4 N2 - Local epidemiologic data on the etiologies of patients hospitalized with community-acquired pneumonia (CAP) is needed to develop guidelines for clinical practice. This study was conducted prospectively to determine the proportion of atypical bacterial pathogens in adults patients hospitalized with CAP in Korea between October 2001 and December 2002. Microbiological diagnosis was determined by serology for antibodies to Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila. Nucleic acid of M. pneumoniae and C. pneumoniae in respiratory samples and Legionella antigen in urine samples were detected. The study population consisted of 126 patients (71 males, 55 females), averaging 54.6 yr (SD+/-17.8), whose paired sera were available. An etiologic diagnosis for atypical pathogens was made in 18 patients (14.3%): C. pneumoniae 9 (7.1%), M. pneumoniae 8 (6.3%), and L. pneumophila 3 patients (2.4%). Streptococcus preumoniae and other typical pathogens were isolated from 36 patients (28.6%). Of 126 patients, 16 (12.7%) were admitted to intensive care unit and atypical pathogens were identified in 5 patients (31.3%). Initial clinical features of patients with pneumonia due to atypical, typical or undetermined pathogens were indistinguishable. We conclude that atypical pathogens should be seriously considered in hospitalized patients with CAP, when initiating empiric treatment in Korea. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/16891800/Atypical_pathogens_as_etiologic_agents_in_hospitalized_patients_with_community_acquired_pneumonia_in_Korea:_a_prospective_multi_center_study_ DB - PRIME DP - Unbound Medicine ER -