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Relation of low-grade inflammation and endothelial activation to blood pressure in obese children and adolescents.
Neuro Endocrinol Lett. 2006 Aug; 27(4):459-64.NE

Abstract

OBJECTIVE

To determine the role of low-grade, systemic inflammation and endothelial activation in the modulation of blood pressure (BP) independently of other traditional risk factors in obese children and adolescents.

DESIGN

We surveyed 281 obese subjects, aged 6-18 years to investigate the relationship of serum inflammation and endothelial activation markers and blood pressure.

MEASUREMENTS

Clinical variables, indices of obesity, ambulatory 24-h blood pressure and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), glucose and insulin. HOMA IR was used as a marker of insulin resistance (IR).

RESULTS

CRP, IL-6, IL-1 beta, and ICAM-1 correlated significantly with mean 24-h systolic BP, whereas CRP and IL-6 was positively correlated with mean 24-h diastolic BP. Multiple regression analysis showed that serum IL-6 (P < .001) concentration, HOMA IR (P < .01), and waist to hip ratio (P < .05) were the significant determinants of systolic BP, whereas CRP (P < .05) level was the only predictor of diastolic BP. There were no significant associations of cell adhesion molecules with BP.

CONCLUSIONS

These results indicate that low-grade inflammation may play a role in the modulation of arterial BP relatively early in life.

Authors+Show Affiliations

Department of Endocrinology, Arterial Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland. anhelli@asymed.ifg.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16891995

Citation

Syrenicz, Anhelli, et al. "Relation of Low-grade Inflammation and Endothelial Activation to Blood Pressure in Obese Children and Adolescents." Neuro Endocrinology Letters, vol. 27, no. 4, 2006, pp. 459-64.
Syrenicz A, Garanty-Bogacka B, Syrenicz M, et al. Relation of low-grade inflammation and endothelial activation to blood pressure in obese children and adolescents. Neuro Endocrinol Lett. 2006;27(4):459-64.
Syrenicz, A., Garanty-Bogacka, B., Syrenicz, M., Gebala, A., Dawid, G., & Walczak, M. (2006). Relation of low-grade inflammation and endothelial activation to blood pressure in obese children and adolescents. Neuro Endocrinology Letters, 27(4), 459-64.
Syrenicz A, et al. Relation of Low-grade Inflammation and Endothelial Activation to Blood Pressure in Obese Children and Adolescents. Neuro Endocrinol Lett. 2006;27(4):459-64. PubMed PMID: 16891995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of low-grade inflammation and endothelial activation to blood pressure in obese children and adolescents. AU - Syrenicz,Anhelli, AU - Garanty-Bogacka,Barbara, AU - Syrenicz,Małgorzata, AU - Gebala,Aneta, AU - Dawid,Grazyna, AU - Walczak,Mieczysław, PY - 2006/07/01/received PY - 2006/07/17/accepted PY - 2006/8/8/pubmed PY - 2007/2/13/medline PY - 2006/8/8/entrez SP - 459 EP - 64 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 27 IS - 4 N2 - OBJECTIVE: To determine the role of low-grade, systemic inflammation and endothelial activation in the modulation of blood pressure (BP) independently of other traditional risk factors in obese children and adolescents. DESIGN: We surveyed 281 obese subjects, aged 6-18 years to investigate the relationship of serum inflammation and endothelial activation markers and blood pressure. MEASUREMENTS: Clinical variables, indices of obesity, ambulatory 24-h blood pressure and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), glucose and insulin. HOMA IR was used as a marker of insulin resistance (IR). RESULTS: CRP, IL-6, IL-1 beta, and ICAM-1 correlated significantly with mean 24-h systolic BP, whereas CRP and IL-6 was positively correlated with mean 24-h diastolic BP. Multiple regression analysis showed that serum IL-6 (P < .001) concentration, HOMA IR (P < .01), and waist to hip ratio (P < .05) were the significant determinants of systolic BP, whereas CRP (P < .05) level was the only predictor of diastolic BP. There were no significant associations of cell adhesion molecules with BP. CONCLUSIONS: These results indicate that low-grade inflammation may play a role in the modulation of arterial BP relatively early in life. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/16891995/Relation_of_low_grade_inflammation_and_endothelial_activation_to_blood_pressure_in_obese_children_and_adolescents_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -