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Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents.
Neuro Endocrinol Lett. 2006 Aug; 27(4):453-8.NE

Abstract

BACKGROUND

There is growing evidence that low-grade systemic inflammation is closely involved in the pathogenesis of type 2 diabetes.

OBJECTIVE

The aim of this study was to investigate the relationship between serum inflammatory markers and selected parameters known as risk factors of type 2 diabetes in obese children and adolescents.

SUBJECTS AND METHODS

Fasting levels of C-reactive protein (CRP), fibrinogen (FB) interleukin-6 (IL-6), interleukin 1-beta (IL-1beta), glucose, insulin, total, HDL and LDL cholesterol, triglycerides, white blood cell count (WBC) and fasting glucose to insulin ratio (FGIR) were measured in 281 obese children and adolescents. Pearson's correlation was used for assessing the relationship between inflammatory markers and selected clinical parameters.

RESULTS

Inflammatory markers correlated significantly with insulin resistance indices, HbA1c, lipid profile, hypertension, positive family history of type 2 diabetes, low physical fitness, and mixed high-fat and high-carbohydrate diet.

CONCLUSIONS

Serum inflammatory markers were significantly correlated with most factors implicated in the development of type 2 diabetes. These data provide additional support for previously reported in adults relationship between subclinical inflammation and the risk of type 2 diabetes.

Authors+Show Affiliations

Department of Endocrinology, Arterial Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland. anhelli@asymed.ifg.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16892000

Citation

Syrenicz, Anhelli, et al. "Low-grade Systemic Inflammation and the Risk of Type 2 Diabetes in Obese Children and Adolescents." Neuro Endocrinology Letters, vol. 27, no. 4, 2006, pp. 453-8.
Syrenicz A, Garanty-Bogacka B, Syrenicz M, et al. Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents. Neuro Endocrinol Lett. 2006;27(4):453-8.
Syrenicz, A., Garanty-Bogacka, B., Syrenicz, M., Gebala, A., & Walczak, M. (2006). Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents. Neuro Endocrinology Letters, 27(4), 453-8.
Syrenicz A, et al. Low-grade Systemic Inflammation and the Risk of Type 2 Diabetes in Obese Children and Adolescents. Neuro Endocrinol Lett. 2006;27(4):453-8. PubMed PMID: 16892000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents. AU - Syrenicz,Anhelli, AU - Garanty-Bogacka,Barbara, AU - Syrenicz,Małgorzata, AU - Gebala,Aneta, AU - Walczak,Mieczysław, PY - 2006/07/01/received PY - 2006/07/17/accepted PY - 2006/8/8/pubmed PY - 2007/2/13/medline PY - 2006/8/8/entrez SP - 453 EP - 8 JF - Neuro endocrinology letters JO - Neuro Endocrinol Lett VL - 27 IS - 4 N2 - BACKGROUND: There is growing evidence that low-grade systemic inflammation is closely involved in the pathogenesis of type 2 diabetes. OBJECTIVE: The aim of this study was to investigate the relationship between serum inflammatory markers and selected parameters known as risk factors of type 2 diabetes in obese children and adolescents. SUBJECTS AND METHODS: Fasting levels of C-reactive protein (CRP), fibrinogen (FB) interleukin-6 (IL-6), interleukin 1-beta (IL-1beta), glucose, insulin, total, HDL and LDL cholesterol, triglycerides, white blood cell count (WBC) and fasting glucose to insulin ratio (FGIR) were measured in 281 obese children and adolescents. Pearson's correlation was used for assessing the relationship between inflammatory markers and selected clinical parameters. RESULTS: Inflammatory markers correlated significantly with insulin resistance indices, HbA1c, lipid profile, hypertension, positive family history of type 2 diabetes, low physical fitness, and mixed high-fat and high-carbohydrate diet. CONCLUSIONS: Serum inflammatory markers were significantly correlated with most factors implicated in the development of type 2 diabetes. These data provide additional support for previously reported in adults relationship between subclinical inflammation and the risk of type 2 diabetes. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/16892000/Low_grade_systemic_inflammation_and_the_risk_of_type_2_diabetes_in_obese_children_and_adolescents_ L2 - http://www.diseaseinfosearch.org/result/2243 DB - PRIME DP - Unbound Medicine ER -