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Decidual NK cells regulate key developmental processes at the human fetal-maternal interface.
Nat Med. 2006 Sep; 12(9):1065-74.NMed

Abstract

Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells. However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein-10 chemokines. Furthermore, dNK cells are potent secretors of an array of angiogenic factors and induce vascular growth in the decidua. Notably, such functions are regulated by specific interactions between dNK-activating and dNK-inhibitory receptors and their ligands, uniquely expressed at the fetal-maternal interface. The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development.

Authors+Show Affiliations

The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16892062

Citation

Hanna, Jacob, et al. "Decidual NK Cells Regulate Key Developmental Processes at the Human Fetal-maternal Interface." Nature Medicine, vol. 12, no. 9, 2006, pp. 1065-74.
Hanna J, Goldman-Wohl D, Hamani Y, et al. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med. 2006;12(9):1065-74.
Hanna, J., Goldman-Wohl, D., Hamani, Y., Avraham, I., Greenfield, C., Natanson-Yaron, S., Prus, D., Cohen-Daniel, L., Arnon, T. I., Manaster, I., Gazit, R., Yutkin, V., Benharroch, D., Porgador, A., Keshet, E., Yagel, S., & Mandelboim, O. (2006). Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nature Medicine, 12(9), 1065-74.
Hanna J, et al. Decidual NK Cells Regulate Key Developmental Processes at the Human Fetal-maternal Interface. Nat Med. 2006;12(9):1065-74. PubMed PMID: 16892062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. AU - Hanna,Jacob, AU - Goldman-Wohl,Debra, AU - Hamani,Yaron, AU - Avraham,Inbal, AU - Greenfield,Caryn, AU - Natanson-Yaron,Shira, AU - Prus,Diana, AU - Cohen-Daniel,Leonor, AU - Arnon,Tal I, AU - Manaster,Irit, AU - Gazit,Roi, AU - Yutkin,Vladimir, AU - Benharroch,Daniel, AU - Porgador,Angel, AU - Keshet,Eli, AU - Yagel,Simcha, AU - Mandelboim,Ofer, Y1 - 2006/08/06/ PY - 2006/03/16/received PY - 2006/06/26/accepted PY - 2006/8/8/pubmed PY - 2006/12/9/medline PY - 2006/8/8/entrez SP - 1065 EP - 74 JF - Nature medicine JO - Nat. Med. VL - 12 IS - 9 N2 - Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells. However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein-10 chemokines. Furthermore, dNK cells are potent secretors of an array of angiogenic factors and induce vascular growth in the decidua. Notably, such functions are regulated by specific interactions between dNK-activating and dNK-inhibitory receptors and their ligands, uniquely expressed at the fetal-maternal interface. The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development. SN - 1078-8956 UR - https://www.unboundmedicine.com/medline/citation/16892062/Decidual_NK_cells_regulate_key_developmental_processes_at_the_human_fetal_maternal_interface_ L2 - http://dx.doi.org/10.1038/nm1452 DB - PRIME DP - Unbound Medicine ER -