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Neonatal caffeine administration causes a permanent increase in the dendritic length of prefrontal cortical neurons of rats.
Synapse. 2006 Nov; 60(6):450-5.S

Abstract

We studied the morphological changes of the dendritic length of the pyramidal neurons of the prefrontal cortex (PFC) induced by the effect of chronic administration of caffeine in the neonatal rat. The caffeine (50 mg/kg, s.c.) was injected from day 1 after birth (P1) to day 12 (P12). The morphology of the pyramidal neurons of layer 3 of the PFC was investigated in these animals at two different ages, before puberty (P35) and after puberty (P70). Before the animals were sacrificed by using overdoses of sodium pentobarbital and being perfused intracardially with 0.9% saline, the locomotor activity in a novel environment was measured. The brains were then removed, processed by the Golgi-Cox stain, and analyzed by the Sholl method. The dendritic morphology clearly showed that the neonatal animals administered caffeine showed an increase in the dendritic length of the pyramidal neurons of the PFC when compared with the control animals at both ages. The present results suggest that neonatal administration of caffeine may in part affect the dendritic morphology of the pyramidal cells of this limbic structure and this effect persists after puberty and may be implicated in several brain processes.

Authors+Show Affiliations

Escuela de Biología, Universidad Autónoma de Puebla, Puebla, México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16892188

Citation

Juárez-Méndez, Sergio, et al. "Neonatal Caffeine Administration Causes a Permanent Increase in the Dendritic Length of Prefrontal Cortical Neurons of Rats." Synapse (New York, N.Y.), vol. 60, no. 6, 2006, pp. 450-5.
Juárez-Méndez S, Carretero R, Martínez-Tellez R, et al. Neonatal caffeine administration causes a permanent increase in the dendritic length of prefrontal cortical neurons of rats. Synapse. 2006;60(6):450-5.
Juárez-Méndez, S., Carretero, R., Martínez-Tellez, R., Silva-Gómez, A. B., & Flores, G. (2006). Neonatal caffeine administration causes a permanent increase in the dendritic length of prefrontal cortical neurons of rats. Synapse (New York, N.Y.), 60(6), 450-5.
Juárez-Méndez S, et al. Neonatal Caffeine Administration Causes a Permanent Increase in the Dendritic Length of Prefrontal Cortical Neurons of Rats. Synapse. 2006;60(6):450-5. PubMed PMID: 16892188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal caffeine administration causes a permanent increase in the dendritic length of prefrontal cortical neurons of rats. AU - Juárez-Méndez,Sergio, AU - Carretero,Rosalba, AU - Martínez-Tellez,Rubelia, AU - Silva-Gómez,Adriana B, AU - Flores,Gonzalo, PY - 2006/8/8/pubmed PY - 2006/10/20/medline PY - 2006/8/8/entrez SP - 450 EP - 5 JF - Synapse (New York, N.Y.) JO - Synapse VL - 60 IS - 6 N2 - We studied the morphological changes of the dendritic length of the pyramidal neurons of the prefrontal cortex (PFC) induced by the effect of chronic administration of caffeine in the neonatal rat. The caffeine (50 mg/kg, s.c.) was injected from day 1 after birth (P1) to day 12 (P12). The morphology of the pyramidal neurons of layer 3 of the PFC was investigated in these animals at two different ages, before puberty (P35) and after puberty (P70). Before the animals were sacrificed by using overdoses of sodium pentobarbital and being perfused intracardially with 0.9% saline, the locomotor activity in a novel environment was measured. The brains were then removed, processed by the Golgi-Cox stain, and analyzed by the Sholl method. The dendritic morphology clearly showed that the neonatal animals administered caffeine showed an increase in the dendritic length of the pyramidal neurons of the PFC when compared with the control animals at both ages. The present results suggest that neonatal administration of caffeine may in part affect the dendritic morphology of the pyramidal cells of this limbic structure and this effect persists after puberty and may be implicated in several brain processes. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/16892188/Neonatal_caffeine_administration_causes_a_permanent_increase_in_the_dendritic_length_of_prefrontal_cortical_neurons_of_rats_ DB - PRIME DP - Unbound Medicine ER -