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Treatment of advanced Parkinson's disease.
Expert Rev Neurother. 2006 Aug; 6(8):1181-97.ER

Abstract

Parkinson's disease is a progressive neurological disorder characterized by tremor, bradykinesia, rigidity, gait and postural instability and a variety of nonmotor symptoms. While these and other motor signs typically improve with levodopa, the so-called axial signs, such as dysarthria, dysphagia, postural instability and freezing, and most nonmotor signs, such as depression, cognitive decline and dysautonomia, usually do not respond satisfactorily to levodopa. Furthermore, the use of levodopa may be limited by the development of motor fluctuations, dyskinesias and other adverse effects. This manuscript reviews the medical management of advanced Parkinson's disease, focusing on the treatment of motor fluctuations and dyskinesias and of nonmotor and nonlevodopa responsive symptoms.

Authors+Show Affiliations

Movement Disorder Clinic, Colorado Neurologic Institute, 701 East Hampden Ave. Suite 330 Englewood, CO 80113, USA. Neurodoc01@sbcglobal.netNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16893346

Citation

Diamond, Alan, and Joseph Jankovic. "Treatment of Advanced Parkinson's Disease." Expert Review of Neurotherapeutics, vol. 6, no. 8, 2006, pp. 1181-97.
Diamond A, Jankovic J. Treatment of advanced Parkinson's disease. Expert Rev Neurother. 2006;6(8):1181-97.
Diamond, A., & Jankovic, J. (2006). Treatment of advanced Parkinson's disease. Expert Review of Neurotherapeutics, 6(8), 1181-97.
Diamond A, Jankovic J. Treatment of Advanced Parkinson's Disease. Expert Rev Neurother. 2006;6(8):1181-97. PubMed PMID: 16893346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of advanced Parkinson's disease. AU - Diamond,Alan, AU - Jankovic,Joseph, PY - 2006/8/9/pubmed PY - 2006/9/13/medline PY - 2006/8/9/entrez SP - 1181 EP - 97 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 6 IS - 8 N2 - Parkinson's disease is a progressive neurological disorder characterized by tremor, bradykinesia, rigidity, gait and postural instability and a variety of nonmotor symptoms. While these and other motor signs typically improve with levodopa, the so-called axial signs, such as dysarthria, dysphagia, postural instability and freezing, and most nonmotor signs, such as depression, cognitive decline and dysautonomia, usually do not respond satisfactorily to levodopa. Furthermore, the use of levodopa may be limited by the development of motor fluctuations, dyskinesias and other adverse effects. This manuscript reviews the medical management of advanced Parkinson's disease, focusing on the treatment of motor fluctuations and dyskinesias and of nonmotor and nonlevodopa responsive symptoms. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/16893346/Treatment_of_advanced_Parkinson's_disease_ L2 - https://www.tandfonline.com/doi/full/10.1586/14737175.6.8.1181 DB - PRIME DP - Unbound Medicine ER -