Tags

Type your tag names separated by a space and hit enter

Statin therapy in patients with chronic kidney disease: to use or not to use.
Eur J Clin Invest. 2006 Aug; 36(8):519-27.EJ

Abstract

Dyslipdemia is a common complication of chronic kidney disease (CKD) and contributes to high cardiovascular morbidity and mortality of CKD patients. Experimental studies have demonstrated that lipids induce glomerular and tubulointerstitial injury and that lipid-lowering treatments ameliorate renal injury. Therapy with statins not only has the potential to lower cardiovascular morbidity and mortality in patients with CKD but also to slow progression of renal disease. Whereas the guidelines for treatment of hyperlipidaemia in nonrenal patients are based on prospective, randomized, placebo-controlled mega-trials, such data are not available for CKD patients. This review outlines the limited information currently available on the effect of statins among patients with CKD and summarizes the ongoing randomized trials designed to address this question.

Links

Aggregator Full Text

Authors+Show Affiliations

Steinmetz OM
Department of Medicine, Division of Nephrology, University Hospital of Hamburg Eppendorf, Hamburg, Germany.
Panzer U
No affiliation info available
Stahl RA
No affiliation info available
Wenzel UO
No affiliation info available

MeSH

CholesterolChronic DiseaseClinical Trials as TopicHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaKidney DiseasesKidney Failure, ChronicKidney TransplantationProteinuriaTreatment Outcome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16893373

Citation

Steinmetz, O M., et al. "Statin Therapy in Patients With Chronic Kidney Disease: to Use or Not to Use." European Journal of Clinical Investigation, vol. 36, no. 8, 2006, pp. 519-27.
Steinmetz OM, Panzer U, Stahl RA, et al. Statin therapy in patients with chronic kidney disease: to use or not to use. Eur J Clin Invest. 2006;36(8):519-27.
Steinmetz, O. M., Panzer, U., Stahl, R. A., & Wenzel, U. O. (2006). Statin therapy in patients with chronic kidney disease: to use or not to use. European Journal of Clinical Investigation, 36(8), 519-27.
Steinmetz OM, et al. Statin Therapy in Patients With Chronic Kidney Disease: to Use or Not to Use. Eur J Clin Invest. 2006;36(8):519-27. PubMed PMID: 16893373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin therapy in patients with chronic kidney disease: to use or not to use. AU - Steinmetz,O M, AU - Panzer,U, AU - Stahl,R A K, AU - Wenzel,U O, PY - 2006/8/9/pubmed PY - 2007/2/23/medline PY - 2006/8/9/entrez SP - 519 EP - 27 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 36 IS - 8 N2 - Dyslipdemia is a common complication of chronic kidney disease (CKD) and contributes to high cardiovascular morbidity and mortality of CKD patients. Experimental studies have demonstrated that lipids induce glomerular and tubulointerstitial injury and that lipid-lowering treatments ameliorate renal injury. Therapy with statins not only has the potential to lower cardiovascular morbidity and mortality in patients with CKD but also to slow progression of renal disease. Whereas the guidelines for treatment of hyperlipidaemia in nonrenal patients are based on prospective, randomized, placebo-controlled mega-trials, such data are not available for CKD patients. This review outlines the limited information currently available on the effect of statins among patients with CKD and summarizes the ongoing randomized trials designed to address this question. SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/16893373/Statin_therapy_in_patients_with_chronic_kidney_disease:_to_use_or_not_to_use_ L2 - https://doi.org/10.1111/j.1365-2362.2006.01668.x DB - PRIME DP - Unbound Medicine ER -