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Pulmonary function at peak exercise in patients with chronic heart failure.
Int J Cardiol. 2007 May 16; 118(1):28-35.IJ

Abstract

BACKGROUND

Various respiratory abnormalities are associated with chronic heart failure (CHF). However, changes in inspiratory capacity (IC) and breathing pattern from rest to exercise in patients with CHF have not been thoroughly investigated in these patients.

MATERIALS AND METHODS

Seventy seven (66 male/11 female) patients with clinical stable CHF (age: 52+/-11 years) were studied. All the patients underwent pulmonary function tests, including measurements of IC and maximal inspiratory pressure (Pimax) at rest and then a maximal cardiopulmonary exercise testing (CPET) on a treadmill. During the CPET, IC was measured every 2 min. Pimax was measured again after the end of CPET.

RESULTS

Percent predicted forced expiratory volume in 1 s (FEV1) was 91+/-12, %predicted forced vital capacity (FVC) was 92+/-13, %FEV1/FVC was 81+/-4, and %predicted IC was 85+/-18. Peak exercise IC was lower than resting (2.4+/-0.6 vs. 2.6+/-0.6 l, p<0.001). Analysis of variance between Weber's groups revealed statistically significant differences in peak exercise IC (p<0.001), VE/VCO2slope (p<0.001), resting Pimax (p=0.005) and post-exercise Pimax (p<0.001). At rest, there was a statistically significant difference in end-tidal CO2 (P(ETCO2)) (p=0.002), in breathing frequency (p=0.004), in inspiratory time (Ti) (p=0.04) and in total respiratory time (T(Tot)) (p=0.004) among Weber's groups. At peak exercise there was a statistically significant decrease in minute ventilation (VE) (p<0.001), tidal volume (VT) (p<0.001), respiratory cycle (VT/TI) (p<0.001) and P(ETCO2) (p<0.001). Peak IC was correlated with peak VO2 (r=0.72, p<0.001), anaerobic threshold (r=0.71, p<0.001), VO2/t slope (r=0.54, p<0.0001), and post-exercise Pimax (r=0.62, p<0.001).

CONCLUSIONS

In patients with CHF, peak exercise IC is reduced in parallel with disease severity, which is probably due to respiratory muscle dysfunction.

Authors+Show Affiliations

Pulmonary and Critical Care Medicine Department, Cardiopulmonary Exercise Testing Laboratory and Rehabilitation Center, National and Kapodestrian University of Athens, Evgenidio Hospital, 20, Papadiamantopoulou str, Athens 115 28, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16893579

Citation

Papazachou, Ourania, et al. "Pulmonary Function at Peak Exercise in Patients With Chronic Heart Failure." International Journal of Cardiology, vol. 118, no. 1, 2007, pp. 28-35.
Papazachou O, Anastasiou-Nana M, Sakellariou D, et al. Pulmonary function at peak exercise in patients with chronic heart failure. Int J Cardiol. 2007;118(1):28-35.
Papazachou, O., Anastasiou-Nana, M., Sakellariou, D., Tassiou, A., Dimopoulos, S., Venetsanakos, J., Maroulidis, G., Drakos, S., Roussos, C., & Nanas, S. (2007). Pulmonary function at peak exercise in patients with chronic heart failure. International Journal of Cardiology, 118(1), 28-35.
Papazachou O, et al. Pulmonary Function at Peak Exercise in Patients With Chronic Heart Failure. Int J Cardiol. 2007 May 16;118(1):28-35. PubMed PMID: 16893579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulmonary function at peak exercise in patients with chronic heart failure. AU - Papazachou,Ourania, AU - Anastasiou-Nana,Maria, AU - Sakellariou,Dimitrios, AU - Tassiou,Antonia, AU - Dimopoulos,Stavros, AU - Venetsanakos,John, AU - Maroulidis,George, AU - Drakos,Stavros, AU - Roussos,Charis, AU - Nanas,Serafim, Y1 - 2006/08/08/ PY - 2005/10/18/received PY - 2006/04/02/revised PY - 2006/04/28/accepted PY - 2006/8/9/pubmed PY - 2007/5/5/medline PY - 2006/8/9/entrez SP - 28 EP - 35 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 118 IS - 1 N2 - BACKGROUND: Various respiratory abnormalities are associated with chronic heart failure (CHF). However, changes in inspiratory capacity (IC) and breathing pattern from rest to exercise in patients with CHF have not been thoroughly investigated in these patients. MATERIALS AND METHODS: Seventy seven (66 male/11 female) patients with clinical stable CHF (age: 52+/-11 years) were studied. All the patients underwent pulmonary function tests, including measurements of IC and maximal inspiratory pressure (Pimax) at rest and then a maximal cardiopulmonary exercise testing (CPET) on a treadmill. During the CPET, IC was measured every 2 min. Pimax was measured again after the end of CPET. RESULTS: Percent predicted forced expiratory volume in 1 s (FEV1) was 91+/-12, %predicted forced vital capacity (FVC) was 92+/-13, %FEV1/FVC was 81+/-4, and %predicted IC was 85+/-18. Peak exercise IC was lower than resting (2.4+/-0.6 vs. 2.6+/-0.6 l, p<0.001). Analysis of variance between Weber's groups revealed statistically significant differences in peak exercise IC (p<0.001), VE/VCO2slope (p<0.001), resting Pimax (p=0.005) and post-exercise Pimax (p<0.001). At rest, there was a statistically significant difference in end-tidal CO2 (P(ETCO2)) (p=0.002), in breathing frequency (p=0.004), in inspiratory time (Ti) (p=0.04) and in total respiratory time (T(Tot)) (p=0.004) among Weber's groups. At peak exercise there was a statistically significant decrease in minute ventilation (VE) (p<0.001), tidal volume (VT) (p<0.001), respiratory cycle (VT/TI) (p<0.001) and P(ETCO2) (p<0.001). Peak IC was correlated with peak VO2 (r=0.72, p<0.001), anaerobic threshold (r=0.71, p<0.001), VO2/t slope (r=0.54, p<0.0001), and post-exercise Pimax (r=0.62, p<0.001). CONCLUSIONS: In patients with CHF, peak exercise IC is reduced in parallel with disease severity, which is probably due to respiratory muscle dysfunction. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/16893579/Pulmonary_function_at_peak_exercise_in_patients_with_chronic_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(06)00610-3 DB - PRIME DP - Unbound Medicine ER -