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Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline.
Neurology 2006; 67(3):441-5Neur

Abstract

OBJECTIVE

To examine the extent to which persons with mild cognitive impairment (MCI) have an increased risk of Alzheimer disease (AD) and a more rapid rate of decline in cognitive function compared to similar persons without cognitive impairment.

METHOD

Participants were 786 community-based persons (221 with MCI and 565 without cognitive impairment) from the Rush Memory and Aging Project, an ongoing longitudinal clinical-pathologic study of common chronic conditions of old age. All participants underwent detailed annual clinical and neuropsychological evaluations. The authors examined the risk of incident AD and rate of change in global cognitive function among persons with MCI and those without cognitive impairment; all statistical models controlled for age, sex, and education.

RESULTS

Over an average of 2.5 years of follow-up, 57 persons with MCI (25.8%) developed AD, a rate 6.7 times higher than those without cognitive impairment. In addition, persons with MCI declined considerably more rapidly each year on a measure of global cognitive function than those without cognitive impairment.

CONCLUSIONS

Mild cognitive impairment is associated with a greatly increased risk of incident Alzheimer disease and a more rapid rate of decline in cognitive function.

Authors+Show Affiliations

Rush Alzheimer's Disease Center, Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA. Patricia_Boyle@Rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16894105

Citation

Boyle, P A., et al. "Mild Cognitive Impairment: Risk of Alzheimer Disease and Rate of Cognitive Decline." Neurology, vol. 67, no. 3, 2006, pp. 441-5.
Boyle PA, Wilson RS, Aggarwal NT, et al. Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline. Neurology. 2006;67(3):441-5.
Boyle, P. A., Wilson, R. S., Aggarwal, N. T., Tang, Y., & Bennett, D. A. (2006). Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline. Neurology, 67(3), pp. 441-5.
Boyle PA, et al. Mild Cognitive Impairment: Risk of Alzheimer Disease and Rate of Cognitive Decline. Neurology. 2006 Aug 8;67(3):441-5. PubMed PMID: 16894105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline. AU - Boyle,P A, AU - Wilson,R S, AU - Aggarwal,N T, AU - Tang,Y, AU - Bennett,D A, PY - 2006/8/9/pubmed PY - 2006/9/7/medline PY - 2006/8/9/entrez SP - 441 EP - 5 JF - Neurology JO - Neurology VL - 67 IS - 3 N2 - OBJECTIVE: To examine the extent to which persons with mild cognitive impairment (MCI) have an increased risk of Alzheimer disease (AD) and a more rapid rate of decline in cognitive function compared to similar persons without cognitive impairment. METHOD: Participants were 786 community-based persons (221 with MCI and 565 without cognitive impairment) from the Rush Memory and Aging Project, an ongoing longitudinal clinical-pathologic study of common chronic conditions of old age. All participants underwent detailed annual clinical and neuropsychological evaluations. The authors examined the risk of incident AD and rate of change in global cognitive function among persons with MCI and those without cognitive impairment; all statistical models controlled for age, sex, and education. RESULTS: Over an average of 2.5 years of follow-up, 57 persons with MCI (25.8%) developed AD, a rate 6.7 times higher than those without cognitive impairment. In addition, persons with MCI declined considerably more rapidly each year on a measure of global cognitive function than those without cognitive impairment. CONCLUSIONS: Mild cognitive impairment is associated with a greatly increased risk of incident Alzheimer disease and a more rapid rate of decline in cognitive function. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16894105/Mild_cognitive_impairment:_risk_of_Alzheimer_disease_and_rate_of_cognitive_decline_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16894105 DB - PRIME DP - Unbound Medicine ER -