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Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain.

Abstract

BACKGROUND

The association between typical and atypical symptoms of gastroesophageal reflux (GER) has received little attention in population-based studies. This study therefore sought to examine the prevalence of atypical symptoms, and their association with typical GER symptoms in Spain.

METHODS

A telephone survey using a validated questionnaire was conducted in 2002 on 2500 subjects aged 40-79 years, randomly selected from the general population of Spain. The questionnaire included items on typical GER symptoms (heartburn and acid regurgitation) and several atypical symptoms (chest pain, dysphagia, belching, dyspepsia, globus, hoarseness, hiccups, chronic cough and asthma). The association between typical GER symptoms and each atypical symptom was summarized using odds ratios obtained from logistic regression.

RESULTS

The response rate was 71.2%. A total of 60.8% (95% confidence interval 59.0-62.8%) of subjects reported suffering from at least one atypical symptom during the year preceding the interview. The prevalence rates varied from 26.7% for hoarseness to 6.6% for asthma. The prevalence of atypical symptoms was higher among the 791 subjects with typical GER symptoms than among the 1709 subjects reporting no typical GER symptoms (79.6 versus 52.2%). It was also higher among those reporting frequent typical GER symptoms compared with those reporting occasional symptoms (87.8 versus 58%). After adjustment for age, sex, coffee, alcohol and tobacco consumption, and psychosomatic symptoms, an association (P<0.05) was observed between typical symptoms and the respective atypical symptoms, with odds ratios ranging from 1.4 for asthma to 4.6 for belching. After additional adjustment for the remaining atypical symptoms, chest pain, dysphagia, dyspepsia, belching and globus were each independently associated with typical reflux symptoms.

CONCLUSION

The prevalence of atypical GER symptoms is extremely high. There is an association between typical and atypical GER symptoms, particularly chest pain, dysphagia, dyspepsia, belching and globus.

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  • Authors+Show Affiliations

    ,

    Digestive Disease Service, Hospital Clinico San Carlos, Complutense University, Madrid, Spain. ereydiaz-rubio@sepd.es

    , , ,

    Source

    MeSH

    Adult
    Aged
    Asthma
    Chest Pain
    Cough
    Cross-Sectional Studies
    Deglutition Disorders
    Dyspepsia
    Eructation
    Female
    Gastroesophageal Reflux
    Heartburn
    Hiccup
    Hoarseness
    Humans
    Male
    Middle Aged
    Prevalence
    Risk Factors
    Spain

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16894310

    Citation

    Rey, Enrique, et al. "Prevalence of Atypical Symptoms and Their Association With Typical Symptoms of Gastroesophageal Reflux in Spain." European Journal of Gastroenterology & Hepatology, vol. 18, no. 9, 2006, pp. 969-75.
    Rey E, Elola-Olaso CM, Rodríguez-Artalejo F, et al. Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain. Eur J Gastroenterol Hepatol. 2006;18(9):969-75.
    Rey, E., Elola-Olaso, C. M., Rodríguez-Artalejo, F., Locke, G. R., & Díaz-Rubio, M. (2006). Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain. European Journal of Gastroenterology & Hepatology, 18(9), pp. 969-75.
    Rey E, et al. Prevalence of Atypical Symptoms and Their Association With Typical Symptoms of Gastroesophageal Reflux in Spain. Eur J Gastroenterol Hepatol. 2006;18(9):969-75. PubMed PMID: 16894310.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain. AU - Rey,Enrique, AU - Elola-Olaso,Cristina Moreno, AU - Rodríguez-Artalejo,Fernando, AU - Locke,G Richard,3rd AU - Díaz-Rubio,Manuel, PY - 2006/8/9/pubmed PY - 2007/7/27/medline PY - 2006/8/9/entrez SP - 969 EP - 75 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 18 IS - 9 N2 - BACKGROUND: The association between typical and atypical symptoms of gastroesophageal reflux (GER) has received little attention in population-based studies. This study therefore sought to examine the prevalence of atypical symptoms, and their association with typical GER symptoms in Spain. METHODS: A telephone survey using a validated questionnaire was conducted in 2002 on 2500 subjects aged 40-79 years, randomly selected from the general population of Spain. The questionnaire included items on typical GER symptoms (heartburn and acid regurgitation) and several atypical symptoms (chest pain, dysphagia, belching, dyspepsia, globus, hoarseness, hiccups, chronic cough and asthma). The association between typical GER symptoms and each atypical symptom was summarized using odds ratios obtained from logistic regression. RESULTS: The response rate was 71.2%. A total of 60.8% (95% confidence interval 59.0-62.8%) of subjects reported suffering from at least one atypical symptom during the year preceding the interview. The prevalence rates varied from 26.7% for hoarseness to 6.6% for asthma. The prevalence of atypical symptoms was higher among the 791 subjects with typical GER symptoms than among the 1709 subjects reporting no typical GER symptoms (79.6 versus 52.2%). It was also higher among those reporting frequent typical GER symptoms compared with those reporting occasional symptoms (87.8 versus 58%). After adjustment for age, sex, coffee, alcohol and tobacco consumption, and psychosomatic symptoms, an association (P<0.05) was observed between typical symptoms and the respective atypical symptoms, with odds ratios ranging from 1.4 for asthma to 4.6 for belching. After additional adjustment for the remaining atypical symptoms, chest pain, dysphagia, dyspepsia, belching and globus were each independently associated with typical reflux symptoms. CONCLUSION: The prevalence of atypical GER symptoms is extremely high. There is an association between typical and atypical GER symptoms, particularly chest pain, dysphagia, dyspepsia, belching and globus. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/16894310/Prevalence_of_atypical_symptoms_and_their_association_with_typical_symptoms_of_gastroesophageal_reflux_in_Spain_ L2 - http://Insights.ovid.com/pubmed?pmid=16894310 DB - PRIME DP - Unbound Medicine ER -