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Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) and corticosteroid therapy: eleven United States cases, 1996-2004.
Am J Trop Med Hyg. 2006 Aug; 75(2):333-6.AJ

Abstract

During 1996 through 2004, 29 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) have been reported worldwide; 17 were fatal. Stress-dose corticosteroid (SDS) therapy has recently been found to improve survival among patients with septic shock but benefit for the treatment of YEL-AVD patients in septic shock is unknown. We retrospectively reviewed medical records of 11 U.S. YEL-AVD cases reported to the Vaccine Adverse Event Reporting System (VAERS) from 1996 through 2004. Four of 11 case-patients received SDS; 3 of these 4 (75%) survived. Seven patients did not receive SDS and 2 (29%) survived. Altered mental status was documented on admission for 5 of the 11 patients; 4 of these 5 did not receive SDS and died, whereas one received SDS and survived. The use of stress-dose steroids might be a factor that influenced the survival of these YEL-AVD patients and should be further evaluated in the management of both YEL-AVD and wild-type yellow fever septic shock.

Authors+Show Affiliations

National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. cvellozzi@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16896144

Citation

Vellozzi, Claudia, et al. "Yellow Fever Vaccine-associated Viscerotropic Disease (YEL-AVD) and Corticosteroid Therapy: Eleven United States Cases, 1996-2004." The American Journal of Tropical Medicine and Hygiene, vol. 75, no. 2, 2006, pp. 333-6.
Vellozzi C, Mitchell T, Miller E, et al. Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) and corticosteroid therapy: eleven United States cases, 1996-2004. Am J Trop Med Hyg. 2006;75(2):333-6.
Vellozzi, C., Mitchell, T., Miller, E., Casey, C. G., Eidex, R. B., & Hayes, E. B. (2006). Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) and corticosteroid therapy: eleven United States cases, 1996-2004. The American Journal of Tropical Medicine and Hygiene, 75(2), 333-6.
Vellozzi C, et al. Yellow Fever Vaccine-associated Viscerotropic Disease (YEL-AVD) and Corticosteroid Therapy: Eleven United States Cases, 1996-2004. Am J Trop Med Hyg. 2006;75(2):333-6. PubMed PMID: 16896144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) and corticosteroid therapy: eleven United States cases, 1996-2004. AU - Vellozzi,Claudia, AU - Mitchell,Tarissa, AU - Miller,Elaine, AU - Casey,Christine G, AU - Eidex,Rachel Barwick, AU - Hayes,Edward B, PY - 2006/8/10/pubmed PY - 2006/9/20/medline PY - 2006/8/10/entrez SP - 333 EP - 6 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 75 IS - 2 N2 - During 1996 through 2004, 29 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) have been reported worldwide; 17 were fatal. Stress-dose corticosteroid (SDS) therapy has recently been found to improve survival among patients with septic shock but benefit for the treatment of YEL-AVD patients in septic shock is unknown. We retrospectively reviewed medical records of 11 U.S. YEL-AVD cases reported to the Vaccine Adverse Event Reporting System (VAERS) from 1996 through 2004. Four of 11 case-patients received SDS; 3 of these 4 (75%) survived. Seven patients did not receive SDS and 2 (29%) survived. Altered mental status was documented on admission for 5 of the 11 patients; 4 of these 5 did not receive SDS and died, whereas one received SDS and survived. The use of stress-dose steroids might be a factor that influenced the survival of these YEL-AVD patients and should be further evaluated in the management of both YEL-AVD and wild-type yellow fever septic shock. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/16896144/Yellow_fever_vaccine_associated_viscerotropic_disease__YEL_AVD__and_corticosteroid_therapy:_eleven_United_States_cases_1996_2004_ L2 - http://www.diseaseinfosearch.org/result/7583 DB - PRIME DP - Unbound Medicine ER -