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Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats.
Psychopharmacology (Berl). 2006 Sep; 187(4):397-404.P

Abstract

RATIONALE

Metabotropic glutamate receptors (mGluRs) were reported to regulate various behavioral effects of addictive drugs.

OBJECTIVE

The present study evaluated the role of group I mGluRs in the progressive augmentation ("sensitization") of the behavioral effects observed after repeated, intermittent cocaine exposure.

MATERIALS AND METHODS

After habituation to handling and baseline activity measurement (days 1-2), rats received eight injections of cocaine (10 mg/kg) or saline on days 3-6, 8-11, and then, were tested twice with acute saline and cocaine given in a counterbalanced manner on days 13 and 15. Before the test sessions, subjects were pretreated with mGluR1 antagonist EMQMCM (JNJ16567083, (3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)-methanone methanesulfonate) and mGluR5 antagonist MTEP ([(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine).

RESULTS

Pretreatment with EMQMCM (2.5-10 mg/kg) but not MTEP (2.5-10 mg/kg) significantly reduced expression of the sensitized ambulatory motor activity of the cocaine-experienced animals acutely challenged with cocaine. Both EMQMCM and MTEP significantly reduced vertical motor activity across all cocaine/saline treatment conditions.

CONCLUSIONS

These findings indicate that the expression of behavioral sensitization to cocaine-induced stimulation of locomotor activity may be modulated by group I mGluR antagonists (mGluR1 rather than mGluR5), but these effects occur at the dose levels that attenuate vertical activity.

Authors+Show Affiliations

Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, St Petersburg, Russia. dorav@spmu.rssi.ruNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16896963

Citation

Dravolina, Olga A., et al. "Effects of Group I Metabotropic Glutamate Receptor Antagonists On the Behavioral Sensitization to Motor Effects of Cocaine in Rats." Psychopharmacology, vol. 187, no. 4, 2006, pp. 397-404.
Dravolina OA, Danysz W, Bespalov AY. Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats. Psychopharmacology (Berl). 2006;187(4):397-404.
Dravolina, O. A., Danysz, W., & Bespalov, A. Y. (2006). Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats. Psychopharmacology, 187(4), 397-404.
Dravolina OA, Danysz W, Bespalov AY. Effects of Group I Metabotropic Glutamate Receptor Antagonists On the Behavioral Sensitization to Motor Effects of Cocaine in Rats. Psychopharmacology (Berl). 2006;187(4):397-404. PubMed PMID: 16896963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats. AU - Dravolina,Olga A, AU - Danysz,Wojciech, AU - Bespalov,Anton Y, Y1 - 2006/06/20/ PY - 2005/10/24/received PY - 2006/05/14/accepted PY - 2006/8/10/pubmed PY - 2007/2/3/medline PY - 2006/8/10/entrez SP - 397 EP - 404 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 187 IS - 4 N2 - RATIONALE: Metabotropic glutamate receptors (mGluRs) were reported to regulate various behavioral effects of addictive drugs. OBJECTIVE: The present study evaluated the role of group I mGluRs in the progressive augmentation ("sensitization") of the behavioral effects observed after repeated, intermittent cocaine exposure. MATERIALS AND METHODS: After habituation to handling and baseline activity measurement (days 1-2), rats received eight injections of cocaine (10 mg/kg) or saline on days 3-6, 8-11, and then, were tested twice with acute saline and cocaine given in a counterbalanced manner on days 13 and 15. Before the test sessions, subjects were pretreated with mGluR1 antagonist EMQMCM (JNJ16567083, (3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)-methanone methanesulfonate) and mGluR5 antagonist MTEP ([(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine). RESULTS: Pretreatment with EMQMCM (2.5-10 mg/kg) but not MTEP (2.5-10 mg/kg) significantly reduced expression of the sensitized ambulatory motor activity of the cocaine-experienced animals acutely challenged with cocaine. Both EMQMCM and MTEP significantly reduced vertical motor activity across all cocaine/saline treatment conditions. CONCLUSIONS: These findings indicate that the expression of behavioral sensitization to cocaine-induced stimulation of locomotor activity may be modulated by group I mGluR antagonists (mGluR1 rather than mGluR5), but these effects occur at the dose levels that attenuate vertical activity. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/16896963/Effects_of_group_I_metabotropic_glutamate_receptor_antagonists_on_the_behavioral_sensitization_to_motor_effects_of_cocaine_in_rats_ L2 - https://dx.doi.org/10.1007/s00213-006-0440-1 DB - PRIME DP - Unbound Medicine ER -