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Maternal-fetal transmission of human parvovirus B19 genotype 3.
J Infect Dis. 2006 Sep 01; 194(5):608-11.JI

Abstract

Plasma samples obtained at delivery from 885 pregnant Ghanaian women were tested for human parvovirus B19 DNA and B19-specific antibodies. Maternal-fetal transmission was evaluated by testing paired maternal plasma and umbilical cord blood samples, as well as newborn whole-blood samples when they were available. The B19 DNA seroprevalence rate in women was 1.8% (94% had genotype 3 strains), and the immunoglobulin G (IgG) seroprevalence rate in women was 81%. Two of 3 cases of primary maternal B19 infection resulted in fetal transmission. Coexistence of B19 DNA and B19-specific IgG (persistence) was detected in 13 women (1.5%), but no transmission of the virus was observed. Contrary to the situation in pregnant women with primary B19 infection and high viral loads, pregnant women with low viral loads and B19-specific IgG do not appear to be vertically infectious.

Authors+Show Affiliations

Department of Haematology, National Blood Service, Cambridge Blood Centre, University of Cambridge, Cambridge CB2 2PT, United Kingdom. dc241@cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16897659

Citation

Candotti, Daniel, et al. "Maternal-fetal Transmission of Human Parvovirus B19 Genotype 3." The Journal of Infectious Diseases, vol. 194, no. 5, 2006, pp. 608-11.
Candotti D, Danso K, Parsyan A, et al. Maternal-fetal transmission of human parvovirus B19 genotype 3. J Infect Dis. 2006;194(5):608-11.
Candotti, D., Danso, K., Parsyan, A., Dompreh, A., & Allain, J. P. (2006). Maternal-fetal transmission of human parvovirus B19 genotype 3. The Journal of Infectious Diseases, 194(5), 608-11.
Candotti D, et al. Maternal-fetal Transmission of Human Parvovirus B19 Genotype 3. J Infect Dis. 2006 Sep 1;194(5):608-11. PubMed PMID: 16897659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal-fetal transmission of human parvovirus B19 genotype 3. AU - Candotti,Daniel, AU - Danso,Kwabena, AU - Parsyan,Armen, AU - Dompreh,Albert, AU - Allain,Jean-Pierre, Y1 - 2006/07/24/ PY - 2006/01/10/received PY - 2006/04/18/accepted PY - 2006/8/10/pubmed PY - 2006/10/7/medline PY - 2006/8/10/entrez SP - 608 EP - 11 JF - The Journal of infectious diseases JO - J Infect Dis VL - 194 IS - 5 N2 - Plasma samples obtained at delivery from 885 pregnant Ghanaian women were tested for human parvovirus B19 DNA and B19-specific antibodies. Maternal-fetal transmission was evaluated by testing paired maternal plasma and umbilical cord blood samples, as well as newborn whole-blood samples when they were available. The B19 DNA seroprevalence rate in women was 1.8% (94% had genotype 3 strains), and the immunoglobulin G (IgG) seroprevalence rate in women was 81%. Two of 3 cases of primary maternal B19 infection resulted in fetal transmission. Coexistence of B19 DNA and B19-specific IgG (persistence) was detected in 13 women (1.5%), but no transmission of the virus was observed. Contrary to the situation in pregnant women with primary B19 infection and high viral loads, pregnant women with low viral loads and B19-specific IgG do not appear to be vertically infectious. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/16897659/Maternal_fetal_transmission_of_human_parvovirus_B19_genotype_3_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/506450 DB - PRIME DP - Unbound Medicine ER -