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Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study.
J Clin Periodontol 2006; 33(8):561-7JC

Abstract

OBJECTIVE

The aim of this experimental gingivitis study was to assess the efficacy and safety of two new chlorhexidine (CHX) mouthrinses.

MATERIAL AND METHODS

Ninety volunteers participated in this investigator-blind, randomized, clinical-controlled trial in parallel groups. During the treatment period, no oral hygiene measures except rinsing with non-alcoholic 0.2% CHX or 0.2% CHX/0.055% sodium fluoride mouthrinses, a positive control, or a negative control were permitted. The primary parameter was the gingival index; the secondary parameters were plaque index, discolouration index, and bleeding on probing. Clinical examinations were conducted 14 days before the start of the study, at baseline, and after 7, 14, and 21 days. The two sample t-test, anova, and ancova were used for the statistical analysis.

RESULTS

No difference in efficacy was found between the two new CHX formulations and the positive control. On day 21, statistically significantly less gingival inflammation and plaque accumulation compared with placebo were observed. Besides discolouration and taste irritations, no adverse events were recorded.

CONCLUSION

The two new CHX mouthrinses were able to inhibit plaque re-growth and gingivitis. Neither the omission of alcohol nor the supplementation with sodium fluoride had weakened the clinical efficacy of CHX with respect to the analysed clinical parameters.

Authors+Show Affiliations

Department of Conservative Dentistry Medical Faculty, Dresden University of Technology, Dresden, Germany. kl4@rcs.urz.tu-dresden.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16899099

Citation

Lorenz, K, et al. "Effect of Two New Chlorhexidine Mouthrinses On the Development of Dental Plaque, Gingivitis, and Discolouration. a Randomized, Investigator-blind, Placebo-controlled, 3-week Experimental Gingivitis Study." Journal of Clinical Periodontology, vol. 33, no. 8, 2006, pp. 561-7.
Lorenz K, Bruhn G, Heumann C, et al. Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study. J Clin Periodontol. 2006;33(8):561-7.
Lorenz, K., Bruhn, G., Heumann, C., Netuschil, L., Brecx, M., & Hoffmann, T. (2006). Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study. Journal of Clinical Periodontology, 33(8), pp. 561-7.
Lorenz K, et al. Effect of Two New Chlorhexidine Mouthrinses On the Development of Dental Plaque, Gingivitis, and Discolouration. a Randomized, Investigator-blind, Placebo-controlled, 3-week Experimental Gingivitis Study. J Clin Periodontol. 2006;33(8):561-7. PubMed PMID: 16899099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study. AU - Lorenz,K, AU - Bruhn,G, AU - Heumann,C, AU - Netuschil,L, AU - Brecx,M, AU - Hoffmann,T, PY - 2006/8/11/pubmed PY - 2006/10/21/medline PY - 2006/8/11/entrez SP - 561 EP - 7 JF - Journal of clinical periodontology JO - J. Clin. Periodontol. VL - 33 IS - 8 N2 - OBJECTIVE: The aim of this experimental gingivitis study was to assess the efficacy and safety of two new chlorhexidine (CHX) mouthrinses. MATERIAL AND METHODS: Ninety volunteers participated in this investigator-blind, randomized, clinical-controlled trial in parallel groups. During the treatment period, no oral hygiene measures except rinsing with non-alcoholic 0.2% CHX or 0.2% CHX/0.055% sodium fluoride mouthrinses, a positive control, or a negative control were permitted. The primary parameter was the gingival index; the secondary parameters were plaque index, discolouration index, and bleeding on probing. Clinical examinations were conducted 14 days before the start of the study, at baseline, and after 7, 14, and 21 days. The two sample t-test, anova, and ancova were used for the statistical analysis. RESULTS: No difference in efficacy was found between the two new CHX formulations and the positive control. On day 21, statistically significantly less gingival inflammation and plaque accumulation compared with placebo were observed. Besides discolouration and taste irritations, no adverse events were recorded. CONCLUSION: The two new CHX mouthrinses were able to inhibit plaque re-growth and gingivitis. Neither the omission of alcohol nor the supplementation with sodium fluoride had weakened the clinical efficacy of CHX with respect to the analysed clinical parameters. SN - 0303-6979 UR - https://www.unboundmedicine.com/medline/citation/16899099/Effect_of_two_new_chlorhexidine_mouthrinses_on_the_development_of_dental_plaque_gingivitis_and_discolouration__A_randomized_investigator_blind_placebo_controlled_3_week_experimental_gingivitis_study_ L2 - https://doi.org/10.1111/j.1600-051X.2006.00946.x DB - PRIME DP - Unbound Medicine ER -