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Collaborative trial validation study of two methods, one based on high performance liquid chromatography-tandem mass spectrometry and on gas chromatography-mass spectrometry for the determination of acrylamide in bakery and potato products.
J Chromatogr A. 2006 Nov 03; 1132(1-2):211-8.JC

Abstract

A European inter-laboratory study was conducted to validate two analytical procedures for the determination of acrylamide in bakery ware (crispbreads, biscuits) and potato products (chips), within a concentration range from about 20 microg/kg to about 9000 microgg/kg. The methods are based on gas chromatography-mass spectrometry (GC-MS) of the derivatised analyte and on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) of native acrylamide. Isotope dilution with isotopically labelled acrylamide was an integral part of both methods. The study was evaluated according to internationally accepted guidelines. The performance of the HPLC-MS/MS method was found to be superior to that of the GC-MS method and to be fit-for-the-purpose.

Authors+Show Affiliations

European Commission - Joint Research Centre - Institute for Reference Materials and Measurements, Retieseweg 111, 2400 Geel, Belgium. thomas.wenzl@ec.europa.eu <thomas.wenzl@ec.europa.eu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16899249

Citation

Wenzl, Thomas, et al. "Collaborative Trial Validation Study of Two Methods, One Based On High Performance Liquid Chromatography-tandem Mass Spectrometry and On Gas Chromatography-mass Spectrometry for the Determination of Acrylamide in Bakery and Potato Products." Journal of Chromatography. A, vol. 1132, no. 1-2, 2006, pp. 211-8.
Wenzl T, Karasek L, Rosen J, et al. Collaborative trial validation study of two methods, one based on high performance liquid chromatography-tandem mass spectrometry and on gas chromatography-mass spectrometry for the determination of acrylamide in bakery and potato products. J Chromatogr A. 2006;1132(1-2):211-8.
Wenzl, T., Karasek, L., Rosen, J., Hellenaes, K. E., Crews, C., Castle, L., & Anklam, E. (2006). Collaborative trial validation study of two methods, one based on high performance liquid chromatography-tandem mass spectrometry and on gas chromatography-mass spectrometry for the determination of acrylamide in bakery and potato products. Journal of Chromatography. A, 1132(1-2), 211-8.
Wenzl T, et al. Collaborative Trial Validation Study of Two Methods, One Based On High Performance Liquid Chromatography-tandem Mass Spectrometry and On Gas Chromatography-mass Spectrometry for the Determination of Acrylamide in Bakery and Potato Products. J Chromatogr A. 2006 Nov 3;1132(1-2):211-8. PubMed PMID: 16899249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Collaborative trial validation study of two methods, one based on high performance liquid chromatography-tandem mass spectrometry and on gas chromatography-mass spectrometry for the determination of acrylamide in bakery and potato products. AU - Wenzl,Thomas, AU - Karasek,Lubomir, AU - Rosen,Johan, AU - Hellenaes,Karl-Erik, AU - Crews,Colin, AU - Castle,Laurence, AU - Anklam,Elke, Y1 - 2006/08/08/ PY - 2006/05/22/received PY - 2006/07/03/revised PY - 2006/07/06/accepted PY - 2006/8/11/pubmed PY - 2006/12/16/medline PY - 2006/8/11/entrez SP - 211 EP - 8 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1132 IS - 1-2 N2 - A European inter-laboratory study was conducted to validate two analytical procedures for the determination of acrylamide in bakery ware (crispbreads, biscuits) and potato products (chips), within a concentration range from about 20 microg/kg to about 9000 microgg/kg. The methods are based on gas chromatography-mass spectrometry (GC-MS) of the derivatised analyte and on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) of native acrylamide. Isotope dilution with isotopically labelled acrylamide was an integral part of both methods. The study was evaluated according to internationally accepted guidelines. The performance of the HPLC-MS/MS method was found to be superior to that of the GC-MS method and to be fit-for-the-purpose. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/16899249/Collaborative_trial_validation_study_of_two_methods_one_based_on_high_performance_liquid_chromatography_tandem_mass_spectrometry_and_on_gas_chromatography_mass_spectrometry_for_the_determination_of_acrylamide_in_bakery_and_potato_products_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(06)01341-0 DB - PRIME DP - Unbound Medicine ER -