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Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression.
Neuropharmacology. 2007 Jan; 52(1):71-6.N

Abstract

The triggering of both NMDA receptor-dependent long-term potentiation (LTP) and long-term depression (LTD) in the CA1 region of the hippocampus requires a rise in postsynaptic calcium. A prominent hypothesis has been that the detailed properties of this postsynaptic calcium signal dictate whether LTP or LTD is generated by a given pattern of synaptic activity. Recently, however, evidence has been presented that the subunit composition of the NMDA receptor (NMDAR) determines whether a synapse undergoes LTP or LTD with NR2A-containing NMDARs triggering LTP and NR2B-containing NMDARs triggering LTD. In the present study, the role of NR2B-containing synaptic NMDARs in the induction of LTD in CA1 pyramidal cells has been studied using the selective NR2B antagonists, ifenprodil and Ro25-6981. While both antagonists reduced NMDAR-mediated synaptic currents, neither prevented induction of LTD. These results demonstrate that activation of NR2B-containing NMDARs is not an absolute requirement for the induction of LTD in the hippocampus.

Authors+Show Affiliations

Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304-5485, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16899258

Citation

Morishita, Wade, et al. "Activation of NR2B-containing NMDA Receptors Is Not Required for NMDA Receptor-dependent Long-term Depression." Neuropharmacology, vol. 52, no. 1, 2007, pp. 71-6.
Morishita W, Lu W, Smith GB, et al. Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology. 2007;52(1):71-6.
Morishita, W., Lu, W., Smith, G. B., Nicoll, R. A., Bear, M. F., & Malenka, R. C. (2007). Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology, 52(1), 71-6.
Morishita W, et al. Activation of NR2B-containing NMDA Receptors Is Not Required for NMDA Receptor-dependent Long-term Depression. Neuropharmacology. 2007;52(1):71-6. PubMed PMID: 16899258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. AU - Morishita,Wade, AU - Lu,Wei, AU - Smith,Gordon B, AU - Nicoll,Roger A, AU - Bear,Mark F, AU - Malenka,Robert C, Y1 - 2006/08/08/ PY - 2006/06/15/received PY - 2006/06/30/revised PY - 2006/07/03/accepted PY - 2006/8/11/pubmed PY - 2007/3/3/medline PY - 2006/8/11/entrez SP - 71 EP - 6 JF - Neuropharmacology JO - Neuropharmacology VL - 52 IS - 1 N2 - The triggering of both NMDA receptor-dependent long-term potentiation (LTP) and long-term depression (LTD) in the CA1 region of the hippocampus requires a rise in postsynaptic calcium. A prominent hypothesis has been that the detailed properties of this postsynaptic calcium signal dictate whether LTP or LTD is generated by a given pattern of synaptic activity. Recently, however, evidence has been presented that the subunit composition of the NMDA receptor (NMDAR) determines whether a synapse undergoes LTP or LTD with NR2A-containing NMDARs triggering LTP and NR2B-containing NMDARs triggering LTD. In the present study, the role of NR2B-containing synaptic NMDARs in the induction of LTD in CA1 pyramidal cells has been studied using the selective NR2B antagonists, ifenprodil and Ro25-6981. While both antagonists reduced NMDAR-mediated synaptic currents, neither prevented induction of LTD. These results demonstrate that activation of NR2B-containing NMDARs is not an absolute requirement for the induction of LTD in the hippocampus. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/16899258/Activation_of_NR2B_containing_NMDA_receptors_is_not_required_for_NMDA_receptor_dependent_long_term_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(06)00209-7 DB - PRIME DP - Unbound Medicine ER -