Abstract
BACKGROUND/AIMS
Obesity is one of the most important clinical associations with non-alcoholic steatohepatitis (NASH). Our aim was to assess the prevalence of non-alcoholic fatty liver disease (NAFLD)/NASH in morbidly obese patients and the risk factors to more aggressive liver disease in this population.
METHODS
Review of available studies on prevalence of NAFLD/NASH in severely obese patients submitted to bariatric surgery.
RESULTS
Twelve observational and transversal studies were included, with consecutive recruitment, and prospective evaluation of data, summing 1620 patients with severe obesity. Prevalence of steatosis and NASH was 91% (range: 85-98%) and 37% (24-98%), respectively, with unexpected cirrhosis in 1.7% (1-7%). NASH was not related with age or body mass index, but there was an association between male sex and NASH/hepatic fibrosis. Diabetes mellitus and insulin resistance were the conditions most frequently associated with NASH, and hypertension with advanced hepatic fibrosis.
CONCLUSIONS
There is a very high prevalence of NAFLD in asymptomatic morbidly obese patients, more than one-third presenting histological criteria for NASH. This review underscores the large variations in prevalence of NASH between studies, calling for the need for a better agreement in the use of the histological criteria.
TY - JOUR
T1 - Hepatic histology in obese patients undergoing bariatric surgery.
AU - Machado,Mariana,
AU - Marques-Vidal,Pedro,
AU - Cortez-Pinto,Helena,
Y1 - 2006/07/25/
PY - 2006/05/15/received
PY - 2006/06/05/revised
PY - 2006/06/07/accepted
PY - 2006/8/11/pubmed
PY - 2006/11/15/medline
PY - 2006/8/11/entrez
SP - 600
EP - 6
JF - Journal of hepatology
JO - J Hepatol
VL - 45
IS - 4
N2 - BACKGROUND/AIMS: Obesity is one of the most important clinical associations with non-alcoholic steatohepatitis (NASH). Our aim was to assess the prevalence of non-alcoholic fatty liver disease (NAFLD)/NASH in morbidly obese patients and the risk factors to more aggressive liver disease in this population. METHODS: Review of available studies on prevalence of NAFLD/NASH in severely obese patients submitted to bariatric surgery. RESULTS: Twelve observational and transversal studies were included, with consecutive recruitment, and prospective evaluation of data, summing 1620 patients with severe obesity. Prevalence of steatosis and NASH was 91% (range: 85-98%) and 37% (24-98%), respectively, with unexpected cirrhosis in 1.7% (1-7%). NASH was not related with age or body mass index, but there was an association between male sex and NASH/hepatic fibrosis. Diabetes mellitus and insulin resistance were the conditions most frequently associated with NASH, and hypertension with advanced hepatic fibrosis. CONCLUSIONS: There is a very high prevalence of NAFLD in asymptomatic morbidly obese patients, more than one-third presenting histological criteria for NASH. This review underscores the large variations in prevalence of NASH between studies, calling for the need for a better agreement in the use of the histological criteria.
SN - 0168-8278
UR - https://www.unboundmedicine.com/medline/citation/16899321/Hepatic_histology_in_obese_patients_undergoing_bariatric_surgery_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(06)00384-9
DB - PRIME
DP - Unbound Medicine
ER -