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Hepatic histology in obese patients undergoing bariatric surgery.
J Hepatol. 2006 Oct; 45(4):600-6.JH

Abstract

BACKGROUND/AIMS

Obesity is one of the most important clinical associations with non-alcoholic steatohepatitis (NASH). Our aim was to assess the prevalence of non-alcoholic fatty liver disease (NAFLD)/NASH in morbidly obese patients and the risk factors to more aggressive liver disease in this population.

METHODS

Review of available studies on prevalence of NAFLD/NASH in severely obese patients submitted to bariatric surgery.

RESULTS

Twelve observational and transversal studies were included, with consecutive recruitment, and prospective evaluation of data, summing 1620 patients with severe obesity. Prevalence of steatosis and NASH was 91% (range: 85-98%) and 37% (24-98%), respectively, with unexpected cirrhosis in 1.7% (1-7%). NASH was not related with age or body mass index, but there was an association between male sex and NASH/hepatic fibrosis. Diabetes mellitus and insulin resistance were the conditions most frequently associated with NASH, and hypertension with advanced hepatic fibrosis.

CONCLUSIONS

There is a very high prevalence of NAFLD in asymptomatic morbidly obese patients, more than one-third presenting histological criteria for NASH. This review underscores the large variations in prevalence of NASH between studies, calling for the need for a better agreement in the use of the histological criteria.

Links

Publisher Full Text

Authors+Show Affiliations

Machado M
Departamento de Gastrenterologia, Instituto de Medicina Molecular (IMM), Faculdade de Medicina da Universidade de Lisboa, Portugal.
Marques-Vidal P
No affiliation info available
Cortez-Pinto H
No affiliation info available

MeSH

AdultAge DistributionBariatric SurgeryBody Mass IndexDyslipidemiasFatty LiverFemaleHumansHypertensionLiverLiver CirrhosisMaleMiddle AgedObesity, MorbidPrevalenceSeverity of Illness IndexSex DistributionTransaminases

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16899321

Clinical Trial Links

Efficacy and Safety of Endoscopic Sleeve Gastroplasty Versus Laparoscopic Sleeve Gastrectomy in Obese Subjects With NASH

Citation

Machado, Mariana, et al. "Hepatic Histology in Obese Patients Undergoing Bariatric Surgery." Journal of Hepatology, vol. 45, no. 4, 2006, pp. 600-6.
Machado M, Marques-Vidal P, Cortez-Pinto H. Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol. 2006;45(4):600-6.
Machado, M., Marques-Vidal, P., & Cortez-Pinto, H. (2006). Hepatic histology in obese patients undergoing bariatric surgery. Journal of Hepatology, 45(4), 600-6.
Machado M, Marques-Vidal P, Cortez-Pinto H. Hepatic Histology in Obese Patients Undergoing Bariatric Surgery. J Hepatol. 2006;45(4):600-6. PubMed PMID: 16899321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic histology in obese patients undergoing bariatric surgery. AU - Machado,Mariana, AU - Marques-Vidal,Pedro, AU - Cortez-Pinto,Helena, Y1 - 2006/07/25/ PY - 2006/05/15/received PY - 2006/06/05/revised PY - 2006/06/07/accepted PY - 2006/8/11/pubmed PY - 2006/11/15/medline PY - 2006/8/11/entrez SP - 600 EP - 6 JF - Journal of hepatology JO - J Hepatol VL - 45 IS - 4 N2 - BACKGROUND/AIMS: Obesity is one of the most important clinical associations with non-alcoholic steatohepatitis (NASH). Our aim was to assess the prevalence of non-alcoholic fatty liver disease (NAFLD)/NASH in morbidly obese patients and the risk factors to more aggressive liver disease in this population. METHODS: Review of available studies on prevalence of NAFLD/NASH in severely obese patients submitted to bariatric surgery. RESULTS: Twelve observational and transversal studies were included, with consecutive recruitment, and prospective evaluation of data, summing 1620 patients with severe obesity. Prevalence of steatosis and NASH was 91% (range: 85-98%) and 37% (24-98%), respectively, with unexpected cirrhosis in 1.7% (1-7%). NASH was not related with age or body mass index, but there was an association between male sex and NASH/hepatic fibrosis. Diabetes mellitus and insulin resistance were the conditions most frequently associated with NASH, and hypertension with advanced hepatic fibrosis. CONCLUSIONS: There is a very high prevalence of NAFLD in asymptomatic morbidly obese patients, more than one-third presenting histological criteria for NASH. This review underscores the large variations in prevalence of NASH between studies, calling for the need for a better agreement in the use of the histological criteria. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/16899321/Hepatic_histology_in_obese_patients_undergoing_bariatric_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(06)00384-9 DB - PRIME DP - Unbound Medicine ER -