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Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training.
Obesity (Silver Spring). 2006 Jul; 14(7):1201-10.O

Abstract

OBJECTIVE

Obesity is associated with lower rates of skeletal muscle fatty acid oxidation (FAO), which is linked to insulin resistance. FAO is reduced further in obese African-American (AAW) vs. white women (CW) and may also be lower in lean AAW vs. CW. In lean CW, endurance exercise training (EET) elevates the oxidative capacity of skeletal muscle. Therefore, we determined whether EET would elevate skeletal muscle FAO similarly in AAW and CW with a lower lipid oxidative capacity.

RESEARCH METHODS AND PROCEDURES

In vitro rates of FAO were assessed in rectus abdominus muscle strips using [1- 14C] palmitate (Pal) from lean AAW [BMI = 24.2 +/- 0.9 (standard error) kg/m2] and CW (23.6 +/- 0.8 kg/m2) undergoing voluntary abdominal surgery. Lean AAW (22 +/- 0.9 kg/m(2)) and CW (24 +/- 0.8 kg/m2) and obese AAW (36 +/- 1.2 kg/m2) and CW (40 +/- 1.3 kg/m2) underwent 10 consecutive days of EET on a cycle ergometer (60 min/d, 75% peak oxygen uptake). FAO was measured in vastus lateralis homogenates as captured 14CO2 using [1- 14C] Pal, palmitoyl-CoA (Pal-CoA), and palmityl-carnitine (Pal-Car).

RESULTS

Muscle strip experiments showed suppressed rates of FAO (p = 0.03) in lean AAW vs. CW. EET increased the rates of skeletal muscle Pal oxidation (p = 0.05) in both lean AAW and CW. In obese subjects, Pre-EET Pal (but not Pal-CoA or Pal-Car) oxidation was lower (p = 0.05) in AAW vs. CW. EET increased Pal oxidation 100% in obese AAW (p < 0.05) and 59% (p < 0.05) in obese CW. Similar increases (p < 0.05) in post-EET FAO were observed for Pal-CoA and Pal-Car in both groups.

DISCUSSION

Both lean and obese AAW possess a lower capacity for skeletal muscle FAO, but EET increases FAO similarly in both AAW and CW. These data suggest the use of EET for treatment against obesity and diabetes for both AAW and CW.

Authors+Show Affiliations

The Human Performance Laboratory, Department of Excercise and Sport Science, College of Health and Human Performance, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA. cortrightr@ecu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16899801

Citation

Cortright, Ronald N., et al. "Skeletal Muscle Fat Oxidation Is Increased in African-American and White Women After 10 Days of Endurance Exercise Training." Obesity (Silver Spring, Md.), vol. 14, no. 7, 2006, pp. 1201-10.
Cortright RN, Sandhoff KM, Basilio JL, et al. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. Obesity (Silver Spring). 2006;14(7):1201-10.
Cortright, R. N., Sandhoff, K. M., Basilio, J. L., Berggren, J. R., Hickner, R. C., Hulver, M. W., Dohm, G. L., & Houmard, J. A. (2006). Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. Obesity (Silver Spring, Md.), 14(7), 1201-10.
Cortright RN, et al. Skeletal Muscle Fat Oxidation Is Increased in African-American and White Women After 10 Days of Endurance Exercise Training. Obesity (Silver Spring). 2006;14(7):1201-10. PubMed PMID: 16899801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. AU - Cortright,Ronald N, AU - Sandhoff,Kimberly M, AU - Basilio,Jessica L, AU - Berggren,Jason R, AU - Hickner,Robert C, AU - Hulver,Matthew W, AU - Dohm,G Lynis, AU - Houmard,Joseph A, PY - 2006/8/11/pubmed PY - 2006/12/9/medline PY - 2006/8/11/entrez SP - 1201 EP - 10 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 14 IS - 7 N2 - OBJECTIVE: Obesity is associated with lower rates of skeletal muscle fatty acid oxidation (FAO), which is linked to insulin resistance. FAO is reduced further in obese African-American (AAW) vs. white women (CW) and may also be lower in lean AAW vs. CW. In lean CW, endurance exercise training (EET) elevates the oxidative capacity of skeletal muscle. Therefore, we determined whether EET would elevate skeletal muscle FAO similarly in AAW and CW with a lower lipid oxidative capacity. RESEARCH METHODS AND PROCEDURES: In vitro rates of FAO were assessed in rectus abdominus muscle strips using [1- 14C] palmitate (Pal) from lean AAW [BMI = 24.2 +/- 0.9 (standard error) kg/m2] and CW (23.6 +/- 0.8 kg/m2) undergoing voluntary abdominal surgery. Lean AAW (22 +/- 0.9 kg/m(2)) and CW (24 +/- 0.8 kg/m2) and obese AAW (36 +/- 1.2 kg/m2) and CW (40 +/- 1.3 kg/m2) underwent 10 consecutive days of EET on a cycle ergometer (60 min/d, 75% peak oxygen uptake). FAO was measured in vastus lateralis homogenates as captured 14CO2 using [1- 14C] Pal, palmitoyl-CoA (Pal-CoA), and palmityl-carnitine (Pal-Car). RESULTS: Muscle strip experiments showed suppressed rates of FAO (p = 0.03) in lean AAW vs. CW. EET increased the rates of skeletal muscle Pal oxidation (p = 0.05) in both lean AAW and CW. In obese subjects, Pre-EET Pal (but not Pal-CoA or Pal-Car) oxidation was lower (p = 0.05) in AAW vs. CW. EET increased Pal oxidation 100% in obese AAW (p < 0.05) and 59% (p < 0.05) in obese CW. Similar increases (p < 0.05) in post-EET FAO were observed for Pal-CoA and Pal-Car in both groups. DISCUSSION: Both lean and obese AAW possess a lower capacity for skeletal muscle FAO, but EET increases FAO similarly in both AAW and CW. These data suggest the use of EET for treatment against obesity and diabetes for both AAW and CW. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/16899801/Skeletal_muscle_fat_oxidation_is_increased_in_African_American_and_white_women_after_10_days_of_endurance_exercise_training_ L2 - https://doi.org/10.1038/oby.2006.137 DB - PRIME DP - Unbound Medicine ER -