Tags

Type your tag names separated by a space and hit enter

Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra.
Neurobiol Dis. 2006 Oct; 24(1):183-93.ND

Abstract

The functional role of the long-lasting inflammation found in the substantia nigra (SN) of Parkinson's disease (PD) patients and animal models is unclear. Proinflammatory cytokines such as interleukin-1beta (IL-1beta) could be involved in mediating neuronal demise. However, it is unknown whether the chronic expression of cytokines such as IL-1beta in the SN can alter neuronal vitality. The aim of this study was to investigate the effects of the chronic expression of IL-1beta in the adult rat SN using a recombinant adenovirus expressing IL-1beta. The chronic expression of IL-1beta for 60 days induced dopaminergic cell death in the SN and unilateral akinesia starting only at 21 days post-injection. Microglial cell activation and inflammatory cell infiltrate were associated with dopaminergic cell death and motor disabilities. Astrocytic activation was delayed and associated with scar formation. The chronic expression of a single proinflammatory cytokine as IL-1beta in the SN elicited most of the characteristics of PD, including progressive dopaminergic cell death, akinesia and glial activation. Our data suggest that IL-1beta per se is able to mediate inflammatory-mediated toxic effects in the SN if its expression is sustained. This model will be helpful to identify possible therapeutic targets related to inflammation-derived neurodegeneration in the SN.

Authors+Show Affiliations

Institute Leloir, IIBBA-CONICET, FBMC-FCEyN. Avenue Patricias Argentinas 435 (1405), Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16901708

Citation

Ferrari, Carina Cintia, et al. "Progressive Neurodegeneration and Motor Disabilities Induced By Chronic Expression of IL-1beta in the Substantia Nigra." Neurobiology of Disease, vol. 24, no. 1, 2006, pp. 183-93.
Ferrari CC, Pott Godoy MC, Tarelli R, et al. Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiol Dis. 2006;24(1):183-93.
Ferrari, C. C., Pott Godoy, M. C., Tarelli, R., Chertoff, M., Depino, A. M., & Pitossi, F. J. (2006). Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiology of Disease, 24(1), 183-93.
Ferrari CC, et al. Progressive Neurodegeneration and Motor Disabilities Induced By Chronic Expression of IL-1beta in the Substantia Nigra. Neurobiol Dis. 2006;24(1):183-93. PubMed PMID: 16901708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. AU - Ferrari,Carina Cintia, AU - Pott Godoy,María Clara, AU - Tarelli,Rodolfo, AU - Chertoff,Mariela, AU - Depino,Amaicha Mara, AU - Pitossi,Fernando Juan, Y1 - 2006/08/09/ PY - 2006/01/19/received PY - 2006/06/01/revised PY - 2006/06/20/accepted PY - 2006/8/12/pubmed PY - 2006/11/9/medline PY - 2006/8/12/entrez SP - 183 EP - 93 JF - Neurobiology of disease JO - Neurobiol Dis VL - 24 IS - 1 N2 - The functional role of the long-lasting inflammation found in the substantia nigra (SN) of Parkinson's disease (PD) patients and animal models is unclear. Proinflammatory cytokines such as interleukin-1beta (IL-1beta) could be involved in mediating neuronal demise. However, it is unknown whether the chronic expression of cytokines such as IL-1beta in the SN can alter neuronal vitality. The aim of this study was to investigate the effects of the chronic expression of IL-1beta in the adult rat SN using a recombinant adenovirus expressing IL-1beta. The chronic expression of IL-1beta for 60 days induced dopaminergic cell death in the SN and unilateral akinesia starting only at 21 days post-injection. Microglial cell activation and inflammatory cell infiltrate were associated with dopaminergic cell death and motor disabilities. Astrocytic activation was delayed and associated with scar formation. The chronic expression of a single proinflammatory cytokine as IL-1beta in the SN elicited most of the characteristics of PD, including progressive dopaminergic cell death, akinesia and glial activation. Our data suggest that IL-1beta per se is able to mediate inflammatory-mediated toxic effects in the SN if its expression is sustained. This model will be helpful to identify possible therapeutic targets related to inflammation-derived neurodegeneration in the SN. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/16901708/Progressive_neurodegeneration_and_motor_disabilities_induced_by_chronic_expression_of_IL_1beta_in_the_substantia_nigra_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(06)00147-1 DB - PRIME DP - Unbound Medicine ER -