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A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses.
Planta Med. 2006 Oct; 72(13):1227-31.PM

Abstract

Danggui Buxue Tang (DBT), a Chinese medicinal decoction that is used commonly for treating women's ailments, contains Radix Astragali and Radix Angelicae Sinensis. The ratio of Radix Astragali and Radix Angelicae Sinensis used in DBT should be 5 : 1 as described in China in 1247 A.D. In order to verify the efficacy of this ancient formulation in stimulating the immune responses, DBT prepared from different drug ratios was applied onto cultured T-lymphocytes and macrophages. In cultured T-lymphocytes, DBT induced markedly cell proliferation, secretion of interleukin-2 and phosphorylation of extracellular signal-regulated kinase. In addition, the phagocytosis of cultured macrophages was increased by DBT treatment. The immunomodulatory effects of DBT were revealed to be the strongest in the extract derived from the drug ratio of 5 : 1. The current results verified that the ancient formulation of DBT has been optimized in stimulating immune responses.

Authors+Show Affiliations

Gao QT
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong SAR, People's Republic of China.
Cheung JK
No affiliation info available
Li J
No affiliation info available
Chu GK
No affiliation info available
Duan R
No affiliation info available
Cheung AW
No affiliation info available
Zhao KJ
No affiliation info available
Dong TT
No affiliation info available
Tsim KW
No affiliation info available

MeSH

Angelica sinensisAstragalus propinquusCell ProliferationChemistry, PharmaceuticalChromatography, High Pressure LiquidDrug SynergismDrugs, Chinese HerbalExtracellular Signal-Regulated MAP KinasesImmunologic FactorsInterleukin-2MacrophagesPhagocytosisPhosphorylationPlant ExtractsPlants, MedicinalT-Lymphocytes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16902872

Citation

Gao, Qiu T., et al. "A Chinese Herbal Decoction, Danggui Buxue Tang, Prepared From Radix Astragali and Radix Angelicae Sinensis Stimulates the Immune Responses." Planta Medica, vol. 72, no. 13, 2006, pp. 1227-31.
Gao QT, Cheung JK, Li J, et al. A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses. Planta Med. 2006;72(13):1227-31.
Gao, Q. T., Cheung, J. K., Li, J., Chu, G. K., Duan, R., Cheung, A. W., Zhao, K. J., Dong, T. T., & Tsim, K. W. (2006). A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses. Planta Medica, 72(13), 1227-31.
Gao QT, et al. A Chinese Herbal Decoction, Danggui Buxue Tang, Prepared From Radix Astragali and Radix Angelicae Sinensis Stimulates the Immune Responses. Planta Med. 2006;72(13):1227-31. PubMed PMID: 16902872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Chinese herbal decoction, Danggui Buxue Tang, prepared from Radix Astragali and Radix Angelicae Sinensis stimulates the immune responses. AU - Gao,Qiu T, AU - Cheung,Jerry K, AU - Li,Jun, AU - Chu,Glanice K, AU - Duan,Ran, AU - Cheung,Anna W, AU - Zhao,Kui J, AU - Dong,Tina T, AU - Tsim,Karl W, Y1 - 2006/08/10/ PY - 2006/8/12/pubmed PY - 2007/1/6/medline PY - 2006/8/12/entrez SP - 1227 EP - 31 JF - Planta medica JO - Planta Med VL - 72 IS - 13 N2 - Danggui Buxue Tang (DBT), a Chinese medicinal decoction that is used commonly for treating women's ailments, contains Radix Astragali and Radix Angelicae Sinensis. The ratio of Radix Astragali and Radix Angelicae Sinensis used in DBT should be 5 : 1 as described in China in 1247 A.D. In order to verify the efficacy of this ancient formulation in stimulating the immune responses, DBT prepared from different drug ratios was applied onto cultured T-lymphocytes and macrophages. In cultured T-lymphocytes, DBT induced markedly cell proliferation, secretion of interleukin-2 and phosphorylation of extracellular signal-regulated kinase. In addition, the phagocytosis of cultured macrophages was increased by DBT treatment. The immunomodulatory effects of DBT were revealed to be the strongest in the extract derived from the drug ratio of 5 : 1. The current results verified that the ancient formulation of DBT has been optimized in stimulating immune responses. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/16902872/A_Chinese_herbal_decoction_Danggui_Buxue_Tang_prepared_from_Radix_Astragali_and_Radix_Angelicae_Sinensis_stimulates_the_immune_responses_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓27]

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