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Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function.
J Am Coll Cardiol 2006; 48(4):715-20JACC

Abstract

OBJECTIVES

The purpose of this study was to investigate the influence of dietary fatty acids on the anti-inflammatory properties of high-density lipoproteins (HDL) and vascular function.

BACKGROUND

The effect of dietary fatty acids on atherogenesis remains uncertain.

METHODS

Fourteen adults consumed an isocaloric meal containing either a polyunsaturated or a saturated fat on 2 occasions. The effects of post-prandial HDL on endothelial cell expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were determined. Flow-mediated dilation (FMD) and microvascular reactivity were assessed before and 3 and 6 h after the meal.

RESULTS

Plasma triglycerides, insulin, and nonesterified fatty acids rose after the meals. The HDL collected 6 h after the saturated meal were less effective than HDL isolated from fasting plasma in terms of their ability to inhibit expression of ICAM-1 and VCAM-1, whereas HDL collected 6 h after the polyunsaturated meal had an inhibitory activity that was greater than that of HDL collected from fasting plasma (p < 0.004 and p = 0.01 for comparison of effect of meals on ICAM-1 and VCAM-1, respectively). Post-hyperemic microvascular flow significantly increased at 3 h after the polyunsaturated meal by 45 +/- 14% and by 21 +/- 11% after the saturated meal. The FMD decreased 3 h after the saturated meal by 2.2 +/- 0.9% (p< 0.05 compared with baseline) and by 0.9 +/- 1% after the polyunsaturated meal.

CONCLUSIONS

Consumption of a saturated fat reduces the anti-inflammatory potential of HDL and impairs arterial endothelial function. In contrast, the anti-inflammatory activity of HDL improves after consumption of polyunsaturated fat. These findings highlight novel mechanisms by which different dietary fatty acids may influence key atherogenic processes.

Authors+Show Affiliations

The Heart Research Institute, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16904539

Citation

Nicholls, Stephen J., et al. "Consumption of Saturated Fat Impairs the Anti-inflammatory Properties of High-density Lipoproteins and Endothelial Function." Journal of the American College of Cardiology, vol. 48, no. 4, 2006, pp. 715-20.
Nicholls SJ, Lundman P, Harmer JA, et al. Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. J Am Coll Cardiol. 2006;48(4):715-20.
Nicholls, S. J., Lundman, P., Harmer, J. A., Cutri, B., Griffiths, K. A., Rye, K. A., ... Celermajer, D. S. (2006). Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. Journal of the American College of Cardiology, 48(4), pp. 715-20.
Nicholls SJ, et al. Consumption of Saturated Fat Impairs the Anti-inflammatory Properties of High-density Lipoproteins and Endothelial Function. J Am Coll Cardiol. 2006 Aug 15;48(4):715-20. PubMed PMID: 16904539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. AU - Nicholls,Stephen J, AU - Lundman,Pia, AU - Harmer,Jason A, AU - Cutri,Belinda, AU - Griffiths,Kaye A, AU - Rye,Kerry-Anne, AU - Barter,Philip J, AU - Celermajer,David S, Y1 - 2006/07/24/ PY - 2005/11/23/received PY - 2006/04/13/revised PY - 2006/04/18/accepted PY - 2006/8/15/pubmed PY - 2006/9/22/medline PY - 2006/8/15/entrez SP - 715 EP - 20 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 48 IS - 4 N2 - OBJECTIVES: The purpose of this study was to investigate the influence of dietary fatty acids on the anti-inflammatory properties of high-density lipoproteins (HDL) and vascular function. BACKGROUND: The effect of dietary fatty acids on atherogenesis remains uncertain. METHODS: Fourteen adults consumed an isocaloric meal containing either a polyunsaturated or a saturated fat on 2 occasions. The effects of post-prandial HDL on endothelial cell expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were determined. Flow-mediated dilation (FMD) and microvascular reactivity were assessed before and 3 and 6 h after the meal. RESULTS: Plasma triglycerides, insulin, and nonesterified fatty acids rose after the meals. The HDL collected 6 h after the saturated meal were less effective than HDL isolated from fasting plasma in terms of their ability to inhibit expression of ICAM-1 and VCAM-1, whereas HDL collected 6 h after the polyunsaturated meal had an inhibitory activity that was greater than that of HDL collected from fasting plasma (p < 0.004 and p = 0.01 for comparison of effect of meals on ICAM-1 and VCAM-1, respectively). Post-hyperemic microvascular flow significantly increased at 3 h after the polyunsaturated meal by 45 +/- 14% and by 21 +/- 11% after the saturated meal. The FMD decreased 3 h after the saturated meal by 2.2 +/- 0.9% (p< 0.05 compared with baseline) and by 0.9 +/- 1% after the polyunsaturated meal. CONCLUSIONS: Consumption of a saturated fat reduces the anti-inflammatory potential of HDL and impairs arterial endothelial function. In contrast, the anti-inflammatory activity of HDL improves after consumption of polyunsaturated fat. These findings highlight novel mechanisms by which different dietary fatty acids may influence key atherogenic processes. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/16904539/Consumption_of_saturated_fat_impairs_the_anti_inflammatory_properties_of_high_density_lipoproteins_and_endothelial_function_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(06)01338-6 DB - PRIME DP - Unbound Medicine ER -