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Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats.
Life Sci. 2006 Nov 02; 79(23):2209-16.LS

Abstract

Memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats is associated with impaired brain glucose and energy metabolism, oxidative stress and impaired cholinergic neurotransmission. Treatment with antioxidants and cholinergic agonists has been reported to produce beneficial effect in this model. However, no reports are available on drugs that improve glucose utilization and metabolism. In the present study, we evaluated the effects of pioglitazone on cognitive performance, oxidative stress and glucose utilization in ICV STZ injected rats (3 mg/kg, on day 1 and 3). Pioglitazone (10 and 30 mg/kg) was administered per oral (p.o.) for 14 days, starting 5 days prior to STZ injection. Cognitive performance was assessed using step-through passive avoidance and Morris water maze task. Malondialdehyde (MDA) and glutathione levels in brain were estimated as parameters of oxidative stress. Glucose utilization by brain was assessed as the amount of glucose consumed from the media by the brain. ICV STZ injected rats showed a severe deficit in learning and memory associated with increased MDA levels (+67.5%), decreased glutathione levels (-29.2%) and impaired cerebral glucose utilization (-44.4%). In contrast pioglitazone treatment improved cognitive performance, lowered oxidative stress and improved cerebral glucose utilization in ICV STZ rats. The present study demonstrates the beneficial effects of pioglitazone in the ICV STZ induced cognitive deficits, which can be exploited for the dementia associated with diabetes and age-related neurodegenerative disorder, where oxidative stress and impaired glucose and energy metabolism are involved.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar-160062, Punjab, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16904700

Citation

Pathan, Asif R., et al. "Chronic Administration of Pioglitazone Attenuates Intracerebroventricular Streptozotocin Induced-memory Impairment in Rats." Life Sciences, vol. 79, no. 23, 2006, pp. 2209-16.
Pathan AR, Viswanad B, Sonkusare SK, et al. Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats. Life Sci. 2006;79(23):2209-16.
Pathan, A. R., Viswanad, B., Sonkusare, S. K., & Ramarao, P. (2006). Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats. Life Sciences, 79(23), 2209-16.
Pathan AR, et al. Chronic Administration of Pioglitazone Attenuates Intracerebroventricular Streptozotocin Induced-memory Impairment in Rats. Life Sci. 2006 Nov 2;79(23):2209-16. PubMed PMID: 16904700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats. AU - Pathan,Asif R, AU - Viswanad,Bhoomi, AU - Sonkusare,Swapnil K, AU - Ramarao,Poduri, Y1 - 2006/07/25/ PY - 2005/12/09/received PY - 2006/07/06/revised PY - 2006/07/17/accepted PY - 2006/8/15/pubmed PY - 2006/12/22/medline PY - 2006/8/15/entrez SP - 2209 EP - 16 JF - Life sciences JO - Life Sci VL - 79 IS - 23 N2 - Memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats is associated with impaired brain glucose and energy metabolism, oxidative stress and impaired cholinergic neurotransmission. Treatment with antioxidants and cholinergic agonists has been reported to produce beneficial effect in this model. However, no reports are available on drugs that improve glucose utilization and metabolism. In the present study, we evaluated the effects of pioglitazone on cognitive performance, oxidative stress and glucose utilization in ICV STZ injected rats (3 mg/kg, on day 1 and 3). Pioglitazone (10 and 30 mg/kg) was administered per oral (p.o.) for 14 days, starting 5 days prior to STZ injection. Cognitive performance was assessed using step-through passive avoidance and Morris water maze task. Malondialdehyde (MDA) and glutathione levels in brain were estimated as parameters of oxidative stress. Glucose utilization by brain was assessed as the amount of glucose consumed from the media by the brain. ICV STZ injected rats showed a severe deficit in learning and memory associated with increased MDA levels (+67.5%), decreased glutathione levels (-29.2%) and impaired cerebral glucose utilization (-44.4%). In contrast pioglitazone treatment improved cognitive performance, lowered oxidative stress and improved cerebral glucose utilization in ICV STZ rats. The present study demonstrates the beneficial effects of pioglitazone in the ICV STZ induced cognitive deficits, which can be exploited for the dementia associated with diabetes and age-related neurodegenerative disorder, where oxidative stress and impaired glucose and energy metabolism are involved. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/16904700/Chronic_administration_of_pioglitazone_attenuates_intracerebroventricular_streptozotocin_induced_memory_impairment_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(06)00573-X DB - PRIME DP - Unbound Medicine ER -