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Apolipoprotein E epsilon4 allele in familial and sporadic Parkinson's disease.
Neurosci Lett. 2006 Oct 09; 406(3):235-9.NL

Abstract

Parkinson's disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer's disease (AD). Common risk factors for both diseases have been explored to study potential etiologic interactions between these two neurodegenerative disorders. The APOE epsilon4 allele, previously associated with AD, has also been associated with risk of PD and with the presence of some clinical features in PD patients. However, the role of APOE epsilon4 allele in risk of PD remains unclear. We studied the distribution of APOE alleles in 276 unrelated familial and sporadic PD patients and in 212 controls. Patients and controls were classified by ethnicity. No genetic heterogeneity between Basques and people from other regions of Spain was found. No significant differences in APOE allele distribution between PD patients and controls were found; however, lower epsilon4 allele frequency was observed when the sporadic PD group was analyzed separately. By contrast, an increase in epsilon4 allele frequency was found in familial PD patients with cognitive decline. We conclude that the APOE epsilon4 allele may be associated with the risk of developing PD in isolated cases and that it is linked to the presence of cognitive decline in familial PD in our sample.

Authors+Show Affiliations

Experimental Unit, Donostia Hospital, San Sebastián, Spain. uniexpe2@chdo.osakidetza.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16904828

Citation

Blázquez, L, et al. "Apolipoprotein E Epsilon4 Allele in Familial and Sporadic Parkinson's Disease." Neuroscience Letters, vol. 406, no. 3, 2006, pp. 235-9.
Blázquez L, Otaegui D, Sáenz A, et al. Apolipoprotein E epsilon4 allele in familial and sporadic Parkinson's disease. Neurosci Lett. 2006;406(3):235-9.
Blázquez, L., Otaegui, D., Sáenz, A., Paisán-Ruiz, C., Emparanza, J. I., Ruiz-Martinez, J., Moreno, F., Martí-Massó, J. F., & López de Munain, A. (2006). Apolipoprotein E epsilon4 allele in familial and sporadic Parkinson's disease. Neuroscience Letters, 406(3), 235-9.
Blázquez L, et al. Apolipoprotein E Epsilon4 Allele in Familial and Sporadic Parkinson's Disease. Neurosci Lett. 2006 Oct 9;406(3):235-9. PubMed PMID: 16904828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E epsilon4 allele in familial and sporadic Parkinson's disease. AU - Blázquez,L, AU - Otaegui,D, AU - Sáenz,A, AU - Paisán-Ruiz,C, AU - Emparanza,J I, AU - Ruiz-Martinez,J, AU - Moreno,F, AU - Martí-Massó,J F, AU - López de Munain,A, Y1 - 2006/08/14/ PY - 2006/02/13/received PY - 2006/07/14/revised PY - 2006/07/18/accepted PY - 2006/8/15/pubmed PY - 2006/11/2/medline PY - 2006/8/15/entrez SP - 235 EP - 9 JF - Neuroscience letters JO - Neurosci Lett VL - 406 IS - 3 N2 - Parkinson's disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer's disease (AD). Common risk factors for both diseases have been explored to study potential etiologic interactions between these two neurodegenerative disorders. The APOE epsilon4 allele, previously associated with AD, has also been associated with risk of PD and with the presence of some clinical features in PD patients. However, the role of APOE epsilon4 allele in risk of PD remains unclear. We studied the distribution of APOE alleles in 276 unrelated familial and sporadic PD patients and in 212 controls. Patients and controls were classified by ethnicity. No genetic heterogeneity between Basques and people from other regions of Spain was found. No significant differences in APOE allele distribution between PD patients and controls were found; however, lower epsilon4 allele frequency was observed when the sporadic PD group was analyzed separately. By contrast, an increase in epsilon4 allele frequency was found in familial PD patients with cognitive decline. We conclude that the APOE epsilon4 allele may be associated with the risk of developing PD in isolated cases and that it is linked to the presence of cognitive decline in familial PD in our sample. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16904828/Apolipoprotein_E_epsilon4_allele_in_familial_and_sporadic_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00732-4 DB - PRIME DP - Unbound Medicine ER -