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Serum cholesterol levels and the risk of Parkinson's disease.
Am J Epidemiol. 2006 Nov 15; 164(10):998-1002.AJ

Abstract

Several recent findings suggest a role of lipid and cholesterol metabolism in the pathogenesis of Parkinson's disease. Therefore, the authors examined the association between serum levels of cholesterol and the risk of Parkinson's disease in the prospective, population-based Rotterdam Study among 6,465 subjects aged 55 or more years with repeated in-person examination and on average 9.4 years of follow-up (1990-2004). Higher serum levels of total cholesterol were associated with a significantly decreased risk of Parkinson's disease (age- and sex-adjusted hazard ratio per mmol/liter increase in cholesterol = 0.77, 95% confidence interval: 0.64, 0.94), with evidence for a dose-effect relation. The association was restricted to women and remained unchanged after adjustment for multiple potential confounders. These findings may indicate a role of lipids in the pathogenesis of Parkinson's disease. Alternatively, they could reflect the strong correlation-especially in women-between levels of serum cholesterol and the antioxidant coenzyme Q10. If confirmed, this would provide further support for an important role of oxidative stress in the pathogenesis of Parkinson's disease.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16905642

Citation

de Lau, Lonneke M L., et al. "Serum Cholesterol Levels and the Risk of Parkinson's Disease." American Journal of Epidemiology, vol. 164, no. 10, 2006, pp. 998-1002.
de Lau LM, Koudstaal PJ, Hofman A, et al. Serum cholesterol levels and the risk of Parkinson's disease. Am J Epidemiol. 2006;164(10):998-1002.
de Lau, L. M., Koudstaal, P. J., Hofman, A., & Breteler, M. M. (2006). Serum cholesterol levels and the risk of Parkinson's disease. American Journal of Epidemiology, 164(10), 998-1002.
de Lau LM, et al. Serum Cholesterol Levels and the Risk of Parkinson's Disease. Am J Epidemiol. 2006 Nov 15;164(10):998-1002. PubMed PMID: 16905642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cholesterol levels and the risk of Parkinson's disease. AU - de Lau,Lonneke M L, AU - Koudstaal,Peter J, AU - Hofman,Albert, AU - Breteler,Monique M B, Y1 - 2006/08/11/ PY - 2006/8/15/pubmed PY - 2007/1/6/medline PY - 2006/8/15/entrez SP - 998 EP - 1002 JF - American journal of epidemiology JO - Am J Epidemiol VL - 164 IS - 10 N2 - Several recent findings suggest a role of lipid and cholesterol metabolism in the pathogenesis of Parkinson's disease. Therefore, the authors examined the association between serum levels of cholesterol and the risk of Parkinson's disease in the prospective, population-based Rotterdam Study among 6,465 subjects aged 55 or more years with repeated in-person examination and on average 9.4 years of follow-up (1990-2004). Higher serum levels of total cholesterol were associated with a significantly decreased risk of Parkinson's disease (age- and sex-adjusted hazard ratio per mmol/liter increase in cholesterol = 0.77, 95% confidence interval: 0.64, 0.94), with evidence for a dose-effect relation. The association was restricted to women and remained unchanged after adjustment for multiple potential confounders. These findings may indicate a role of lipids in the pathogenesis of Parkinson's disease. Alternatively, they could reflect the strong correlation-especially in women-between levels of serum cholesterol and the antioxidant coenzyme Q10. If confirmed, this would provide further support for an important role of oxidative stress in the pathogenesis of Parkinson's disease. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16905642/Serum_cholesterol_levels_and_the_risk_of_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -