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C677T methylentetrahydrofulate reductase and angiotensin converting enzyme gene polymorphisms in patients with Alzheimer's disease in Iranian population.
Neurochem Res 2006; 31(8):1079-83NR

Abstract

In recent years numerous data suggest that vascular risk factors may be play a role in Alzheimer's disease (AD). To determine the association of AD with methylentetrahydrofulate reductase (MTHFR) and angiotensin converting enzyme (ACE) as two main vascular risk factors, we examined MTHFR C677T and ACE insertion/deletion (I/D) gene polymorphism in 117 late-onset AD cases and 125 controls. We found no difference in ACE I/D genotype distribution between AD cases and control (P > 0.05) but there was a significant association between AD and the common MTHFR polymorphism C677T. The T allele conferred an increased risk of AD compared to carrying a C allele (P = 0.001, OR = 1.97, 95% CI: 1.3-2.09). Our result suggests a significant increase in risk of AD in cases with the MTHFR T allele, atleast in the Iranian population.

Authors+Show Affiliations

Genetics Research Center, Social Welfare and Rehabilitation Sciences University, Tehran, Iran. keikhaee@uswr.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16906459

Citation

Keikhaee, Mohammad Reza, et al. "C677T Methylentetrahydrofulate Reductase and Angiotensin Converting Enzyme Gene Polymorphisms in Patients With Alzheimer's Disease in Iranian Population." Neurochemical Research, vol. 31, no. 8, 2006, pp. 1079-83.
Keikhaee MR, Hashemi SB, Najmabadi H, et al. C677T methylentetrahydrofulate reductase and angiotensin converting enzyme gene polymorphisms in patients with Alzheimer's disease in Iranian population. Neurochem Res. 2006;31(8):1079-83.
Keikhaee, M. R., Hashemi, S. B., Najmabadi, H., & Noroozian, M. (2006). C677T methylentetrahydrofulate reductase and angiotensin converting enzyme gene polymorphisms in patients with Alzheimer's disease in Iranian population. Neurochemical Research, 31(8), pp. 1079-83.
Keikhaee MR, et al. C677T Methylentetrahydrofulate Reductase and Angiotensin Converting Enzyme Gene Polymorphisms in Patients With Alzheimer's Disease in Iranian Population. Neurochem Res. 2006;31(8):1079-83. PubMed PMID: 16906459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C677T methylentetrahydrofulate reductase and angiotensin converting enzyme gene polymorphisms in patients with Alzheimer's disease in Iranian population. AU - Keikhaee,Mohammad Reza, AU - Hashemi,Susan Bany, AU - Najmabadi,Hossein, AU - Noroozian,Maryam, Y1 - 2006/08/12/ PY - 2006/07/17/accepted PY - 2006/8/15/pubmed PY - 2007/3/23/medline PY - 2006/8/15/entrez SP - 1079 EP - 83 JF - Neurochemical research JO - Neurochem. Res. VL - 31 IS - 8 N2 - In recent years numerous data suggest that vascular risk factors may be play a role in Alzheimer's disease (AD). To determine the association of AD with methylentetrahydrofulate reductase (MTHFR) and angiotensin converting enzyme (ACE) as two main vascular risk factors, we examined MTHFR C677T and ACE insertion/deletion (I/D) gene polymorphism in 117 late-onset AD cases and 125 controls. We found no difference in ACE I/D genotype distribution between AD cases and control (P > 0.05) but there was a significant association between AD and the common MTHFR polymorphism C677T. The T allele conferred an increased risk of AD compared to carrying a C allele (P = 0.001, OR = 1.97, 95% CI: 1.3-2.09). Our result suggests a significant increase in risk of AD in cases with the MTHFR T allele, atleast in the Iranian population. SN - 0364-3190 UR - https://www.unboundmedicine.com/medline/citation/16906459/C677T_methylentetrahydrofulate_reductase_and_angiotensin_converting_enzyme_gene_polymorphisms_in_patients_with_Alzheimer's_disease_in_Iranian_population_ L2 - https://doi.org/10.1007/s11064-006-9119-6 DB - PRIME DP - Unbound Medicine ER -