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Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women.

Abstract

BACKGROUND

Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm.

RESULTS

Body weight increased in both treatment periods (isoflavone: 0.40 +/- 0.94 kg, P < 0.001; placebo: 0.66 +/- 0.87 kg, P = 0.018), with no significant difference between treatments. No significant differences in energy intake were observed (P = 0.634). PYY significantly increased during isoflavone treatment (51 +/- 2 pmol/L vs. 55 +/- 2 pmol/L), but not during placebo (52 +/- 3 pmol/L vs. 50 +/- 2 pmol/L), (P = 0.010 for treatment differences, independent of equol production). Baseline plasma ghrelin was significantly lower in equol producers (110 +/- 16 pmol/L) than in equol non-producers (162 +/- 17 pmol/L; P = 0.025).

CONCLUSION

Soy isoflavone supplementation for eight weeks did not significantly reduce energy intake or body weight, even though plasma PYY increased during isoflavone treatment. Ghrelin remained unaffected by isoflavone treatment. A larger and more rigorous appetite experiment might detect smaller differences in energy intake after isoflavone consumption. However, the results of the present study do not indicate that increased PYY has a major role in the regulation of body weight, at least in healthy postmenopausal women.

Authors+Show Affiliations

German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. m.weickert@dife.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

16907966

Citation

Weickert, Martin O., et al. "Soy Isoflavones Increase Preprandial Peptide YY (PYY), but Have No Effect On Ghrelin and Body Weight in Healthy Postmenopausal Women." Journal of Negative Results in Biomedicine, vol. 5, 2006, p. 11.
Weickert MO, Reimann M, Otto B, et al. Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. J Negat Results Biomed. 2006;5:11.
Weickert, M. O., Reimann, M., Otto, B., Hall, W. L., Vafeiadou, K., Hallund, J., ... Koebnick, C. (2006). Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. Journal of Negative Results in Biomedicine, 5, p. 11.
Weickert MO, et al. Soy Isoflavones Increase Preprandial Peptide YY (PYY), but Have No Effect On Ghrelin and Body Weight in Healthy Postmenopausal Women. J Negat Results Biomed. 2006 Aug 14;5:11. PubMed PMID: 16907966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. AU - Weickert,Martin O, AU - Reimann,Manja, AU - Otto,Bärbel, AU - Hall,Wendy L, AU - Vafeiadou,Katherina, AU - Hallund,Jesper, AU - Ferrari,Marika, AU - Talbot,Duncan, AU - Branca,Francesco, AU - Bügel,Susanne, AU - Williams,Christine M, AU - Zunft,Hans-Joachim, AU - Koebnick,Corinna, Y1 - 2006/08/14/ PY - 2006/06/02/received PY - 2006/08/14/accepted PY - 2006/8/16/pubmed PY - 2006/9/28/medline PY - 2006/8/16/entrez SP - 11 EP - 11 JF - Journal of negative results in biomedicine JO - J Negat Results Biomed VL - 5 N2 - BACKGROUND: Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, and thus influence body weight. In a randomized, double-blind, placebo-controlled, cross-over trial with 34 healthy postmenopausal women (59 +/- 6 years, BMI: 24.7 +/- 2.8 kg/m2), isoflavone-enriched cereal bars (50 mg isoflavones/day; genistein to daidzein ratio 2:1) or non-isoflavone-enriched control bars were consumed for 8 weeks (wash-out period: 8-weeks). Seventeen of the subjects were classified as equol producers. Plasma concentrations of ghrelin and PYY, as well as energy intake and body weight were measured at baseline and after four and eight weeks of each intervention arm. RESULTS: Body weight increased in both treatment periods (isoflavone: 0.40 +/- 0.94 kg, P < 0.001; placebo: 0.66 +/- 0.87 kg, P = 0.018), with no significant difference between treatments. No significant differences in energy intake were observed (P = 0.634). PYY significantly increased during isoflavone treatment (51 +/- 2 pmol/L vs. 55 +/- 2 pmol/L), but not during placebo (52 +/- 3 pmol/L vs. 50 +/- 2 pmol/L), (P = 0.010 for treatment differences, independent of equol production). Baseline plasma ghrelin was significantly lower in equol producers (110 +/- 16 pmol/L) than in equol non-producers (162 +/- 17 pmol/L; P = 0.025). CONCLUSION: Soy isoflavone supplementation for eight weeks did not significantly reduce energy intake or body weight, even though plasma PYY increased during isoflavone treatment. Ghrelin remained unaffected by isoflavone treatment. A larger and more rigorous appetite experiment might detect smaller differences in energy intake after isoflavone consumption. However, the results of the present study do not indicate that increased PYY has a major role in the regulation of body weight, at least in healthy postmenopausal women. SN - 1477-5751 UR - https://www.unboundmedicine.com/medline/citation/16907966/Soy_isoflavones_increase_preprandial_peptide_YY__PYY__but_have_no_effect_on_ghrelin_and_body_weight_in_healthy_postmenopausal_women_ L2 - https://jnrbm.biomedcentral.com/articles/10.1186/1477-5751-5-11 DB - PRIME DP - Unbound Medicine ER -