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The achievement of durable complete cytogenetic remission in late chronic and accelerated phase patients with CML treated with Imatinib mesylate predicts for prolonged response at 6 years.
Blood Cells Mol Dis. 2006 Sep-Oct; 37(2):111-5.BC

Abstract

Despite the positive results achieved by Imatinib mesylate (Imatinib) in the treatment of chronic myeloid leukemia (CML), over the past several years, Imatinib does not eradicate the leukemic clone. The long-term duration of response to the drug is not known. Long-term follow-up of CML patients treated with Imatinib will ultimately define the durability of such treatment and the frequency of reemergence of progressive disease. We present the results of a 6-year follow-up of 40 CML patients either in chronic or accelerated phase who obtained a durable (>6 months) complete cytogenetic remission (CCyR) after treatment with Imatinib in a single center. In 34 cases CCyR was obtained at an Imatinib dose of 400-600 mg/day and in 6 cases after a dose increase to 600-800 mg/day. At a median follow-up of 68 months, 6 cytogenetic relapses (15%) were observed. No progressions to more advanced phases of disease have been detected during the follow-up period. Cytogenetic relapse was predicted by either a decrease in the amount of BCR-ABL transcript of less than 2 logs after the achievement of CCyR (p=0.0041) or a time-to-CCyR of more than 12 months (p<0.0001). This 6-year follow-up of the efficacy of Imatinib therapy in CML patients who obtained a durable CCyR indicates that the relapses rate is low over this period of observation and that the rate of relapse does not increase over time.

Authors+Show Affiliations

University of Milano Bicocca, S. Gerardo Hospital, Monza, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16908206

Citation

Piazza, Rocco G., et al. "The Achievement of Durable Complete Cytogenetic Remission in Late Chronic and Accelerated Phase Patients With CML Treated With Imatinib Mesylate Predicts for Prolonged Response at 6 Years." Blood Cells, Molecules & Diseases, vol. 37, no. 2, 2006, pp. 111-5.
Piazza RG, Magistroni V, Franceschino A, et al. The achievement of durable complete cytogenetic remission in late chronic and accelerated phase patients with CML treated with Imatinib mesylate predicts for prolonged response at 6 years. Blood Cells Mol Dis. 2006;37(2):111-5.
Piazza, R. G., Magistroni, V., Franceschino, A., Andreoni, F., Tornaghi, L., Colnaghi, F., Corneo, G., Pogliani, E. M., & Gambacorti-Passerini, C. (2006). The achievement of durable complete cytogenetic remission in late chronic and accelerated phase patients with CML treated with Imatinib mesylate predicts for prolonged response at 6 years. Blood Cells, Molecules & Diseases, 37(2), 111-5.
Piazza RG, et al. The Achievement of Durable Complete Cytogenetic Remission in Late Chronic and Accelerated Phase Patients With CML Treated With Imatinib Mesylate Predicts for Prolonged Response at 6 Years. Blood Cells Mol Dis. 2006;37(2):111-5. PubMed PMID: 16908206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The achievement of durable complete cytogenetic remission in late chronic and accelerated phase patients with CML treated with Imatinib mesylate predicts for prolonged response at 6 years. AU - Piazza,Rocco G, AU - Magistroni,Vera, AU - Franceschino,Anna, AU - Andreoni,Federica, AU - Tornaghi,Lucia, AU - Colnaghi,Federica, AU - Corneo,Gianmarco, AU - Pogliani,Enrico M, AU - Gambacorti-Passerini,Carlo, Y1 - 2006/08/14/ PY - 2006/06/05/received PY - 2006/06/10/accepted PY - 2006/8/16/pubmed PY - 2006/12/9/medline PY - 2006/8/16/entrez SP - 111 EP - 5 JF - Blood cells, molecules & diseases JO - Blood Cells Mol. Dis. VL - 37 IS - 2 N2 - Despite the positive results achieved by Imatinib mesylate (Imatinib) in the treatment of chronic myeloid leukemia (CML), over the past several years, Imatinib does not eradicate the leukemic clone. The long-term duration of response to the drug is not known. Long-term follow-up of CML patients treated with Imatinib will ultimately define the durability of such treatment and the frequency of reemergence of progressive disease. We present the results of a 6-year follow-up of 40 CML patients either in chronic or accelerated phase who obtained a durable (>6 months) complete cytogenetic remission (CCyR) after treatment with Imatinib in a single center. In 34 cases CCyR was obtained at an Imatinib dose of 400-600 mg/day and in 6 cases after a dose increase to 600-800 mg/day. At a median follow-up of 68 months, 6 cytogenetic relapses (15%) were observed. No progressions to more advanced phases of disease have been detected during the follow-up period. Cytogenetic relapse was predicted by either a decrease in the amount of BCR-ABL transcript of less than 2 logs after the achievement of CCyR (p=0.0041) or a time-to-CCyR of more than 12 months (p<0.0001). This 6-year follow-up of the efficacy of Imatinib therapy in CML patients who obtained a durable CCyR indicates that the relapses rate is low over this period of observation and that the rate of relapse does not increase over time. SN - 1079-9796 UR - https://www.unboundmedicine.com/medline/citation/16908206/The_achievement_of_durable_complete_cytogenetic_remission_in_late_chronic_and_accelerated_phase_patients_with_CML_treated_with_Imatinib_mesylate_predicts_for_prolonged_response_at_6_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1079-9796(06)00154-9 DB - PRIME DP - Unbound Medicine ER -