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Dietary copper and high saturated and trans fat intakes associated with cognitive decline.
Arch Neurol 2006; 63(8):1085-8AN

Abstract

BACKGROUND

Evidence from prospective epidemiologic studies and animal models suggests that intakes of dietary fats and copper may be associated with neurodegenerative diseases.

OBJECTIVE

To examine whether high dietary copper intake is associated with increased cognitive decline among persons who also consume a diet high in saturated and trans fats.

DESIGN

Community-based prospective study.

SETTING

Chicago, Ill. Patients Chicago residents 65 years and older.

MAIN OUTCOME MEASURES

Cognitive function was assessed using 4 cognitive tests administered during in-home interviews at 3-year intervals for 6 years. Dietary assessment was performed with a food frequency questionnaire. Dietary intakes of copper and fats were related to change in global cognitive score (the mean of the 4 tests) among 3718 participants.

RESULTS

Among persons whose diets were high in saturated and trans fats, higher copper intake was associated with a faster rate of cognitive decline. In multiple-adjusted mixed models, the difference in rates for persons in the highest (median, 2.75 mg/d) vs lowest (median, 0.88 mg/d) quintiles of total copper intake was -6.14 standardized units per year (P<.001) or the equivalent of 19 more years of age. There was also a marginally statistically significant association (P = .07) with the highest quintile of food intake of copper (median, 1.51 mg/d) and a strong dose-response association with higher copper dose in vitamin supplements. Copper intake was not associated with cognitive change among persons whose diets were not high in these fats.

CONCLUSION

These data suggest that high dietary intake of copper in conjunction with a diet high in saturated and trans fats may be associated with accelerated cognitive decline.

Authors+Show Affiliations

Department of Internal Medicine, Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W. Jackson Street, Chicago, IL 60612, USA. Martha_C_Morris@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16908733

Citation

Morris, Martha Clare, et al. "Dietary Copper and High Saturated and Trans Fat Intakes Associated With Cognitive Decline." Archives of Neurology, vol. 63, no. 8, 2006, pp. 1085-8.
Morris MC, Evans DA, Tangney CC, et al. Dietary copper and high saturated and trans fat intakes associated with cognitive decline. Arch Neurol. 2006;63(8):1085-8.
Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., Schneider, J. A., Wilson, R. S., & Scherr, P. A. (2006). Dietary copper and high saturated and trans fat intakes associated with cognitive decline. Archives of Neurology, 63(8), pp. 1085-8.
Morris MC, et al. Dietary Copper and High Saturated and Trans Fat Intakes Associated With Cognitive Decline. Arch Neurol. 2006;63(8):1085-8. PubMed PMID: 16908733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary copper and high saturated and trans fat intakes associated with cognitive decline. AU - Morris,Martha Clare, AU - Evans,Denis A, AU - Tangney,Christine C, AU - Bienias,Julia L, AU - Schneider,Julie A, AU - Wilson,Robert S, AU - Scherr,Paul A, PY - 2006/8/16/pubmed PY - 2006/9/1/medline PY - 2006/8/16/entrez SP - 1085 EP - 8 JF - Archives of neurology JO - Arch. Neurol. VL - 63 IS - 8 N2 - BACKGROUND: Evidence from prospective epidemiologic studies and animal models suggests that intakes of dietary fats and copper may be associated with neurodegenerative diseases. OBJECTIVE: To examine whether high dietary copper intake is associated with increased cognitive decline among persons who also consume a diet high in saturated and trans fats. DESIGN: Community-based prospective study. SETTING: Chicago, Ill. Patients Chicago residents 65 years and older. MAIN OUTCOME MEASURES: Cognitive function was assessed using 4 cognitive tests administered during in-home interviews at 3-year intervals for 6 years. Dietary assessment was performed with a food frequency questionnaire. Dietary intakes of copper and fats were related to change in global cognitive score (the mean of the 4 tests) among 3718 participants. RESULTS: Among persons whose diets were high in saturated and trans fats, higher copper intake was associated with a faster rate of cognitive decline. In multiple-adjusted mixed models, the difference in rates for persons in the highest (median, 2.75 mg/d) vs lowest (median, 0.88 mg/d) quintiles of total copper intake was -6.14 standardized units per year (P<.001) or the equivalent of 19 more years of age. There was also a marginally statistically significant association (P = .07) with the highest quintile of food intake of copper (median, 1.51 mg/d) and a strong dose-response association with higher copper dose in vitamin supplements. Copper intake was not associated with cognitive change among persons whose diets were not high in these fats. CONCLUSION: These data suggest that high dietary intake of copper in conjunction with a diet high in saturated and trans fats may be associated with accelerated cognitive decline. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/16908733/Dietary_copper_and_high_saturated_and_trans_fat_intakes_associated_with_cognitive_decline_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.63.8.1085 DB - PRIME DP - Unbound Medicine ER -