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[Reduced-intensity stem cell transplantation using allogeneic peripheral blood stem cells from the same donor for relapsed leukemia after bone marrow transplantation].
Rinsho Ketsueki. 2006 Jul; 47(7):639-44.RK

Abstract

We report the clinical courses of two cases with relapsed acute lymphoblastic leukemia (ALL) after allogeneic bone marrow transplantation (BMT). After reinduction chemotherapy, the patients received reduced-intensity stem cell transplantation using allogeneic peripheral blood stem cells harvested from their previous BMT donors. The conditioning regimen used consisted of fludarabine and melphalan. Graft-versus-host disease (GVHD) prophylaxis was performed with low dose cyclosporin A (CsA, 1 mg/kg/day d.i.v.) on its own. The regimen related toxicity was minimal, and stable engraftment was achieved. Since acute GVHD had not developed by day 30, CsA was stopped abruptly in both cases. After CsA withdrawal, acute GVHD developed, and subsequent chronic GVHD. One of two cases is alive without any relapse of the leukemia 40 months after the peripheral blood stem cell transplantation (PBSCT). In the other case, ALL relapsed 15 months after the PBSCT, however, complete remission was again induced concomitantly with reactivated GVHD. In both these cases, the results suggest that using PBSC as a stem cell source and abrupt cessation of GVHD prophylaxis provided a potent graft-versus-leukemia effect.

Authors+Show Affiliations

Department of Pediatrics, Yokohama City University School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

16910574

Citation

Kuroki, Fumiko, et al. "[Reduced-intensity Stem Cell Transplantation Using Allogeneic Peripheral Blood Stem Cells From the Same Donor for Relapsed Leukemia After Bone Marrow Transplantation]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 47, no. 7, 2006, pp. 639-44.
Kuroki F, Goto H, Yanagimachi M, et al. [Reduced-intensity stem cell transplantation using allogeneic peripheral blood stem cells from the same donor for relapsed leukemia after bone marrow transplantation]. Rinsho Ketsueki. 2006;47(7):639-44.
Kuroki, F., Goto, H., Yanagimachi, M., Kajiwara, R., Fujii, H., Isaki, S., Takahashi, H., Ikuta, K., & Yokota, S. (2006). [Reduced-intensity stem cell transplantation using allogeneic peripheral blood stem cells from the same donor for relapsed leukemia after bone marrow transplantation]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 47(7), 639-44.
Kuroki F, et al. [Reduced-intensity Stem Cell Transplantation Using Allogeneic Peripheral Blood Stem Cells From the Same Donor for Relapsed Leukemia After Bone Marrow Transplantation]. Rinsho Ketsueki. 2006;47(7):639-44. PubMed PMID: 16910574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Reduced-intensity stem cell transplantation using allogeneic peripheral blood stem cells from the same donor for relapsed leukemia after bone marrow transplantation]. AU - Kuroki,Fumiko, AU - Goto,Hiroaki, AU - Yanagimachi,Masakatsu, AU - Kajiwara,Ryosuke, AU - Fujii,Hisaki, AU - Isaki,Sakurako, AU - Takahashi,Hiroyuki, AU - Ikuta,Koichiro, AU - Yokota,Shumpei, PY - 2006/8/17/pubmed PY - 2006/12/13/medline PY - 2006/8/17/entrez SP - 639 EP - 44 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 47 IS - 7 N2 - We report the clinical courses of two cases with relapsed acute lymphoblastic leukemia (ALL) after allogeneic bone marrow transplantation (BMT). After reinduction chemotherapy, the patients received reduced-intensity stem cell transplantation using allogeneic peripheral blood stem cells harvested from their previous BMT donors. The conditioning regimen used consisted of fludarabine and melphalan. Graft-versus-host disease (GVHD) prophylaxis was performed with low dose cyclosporin A (CsA, 1 mg/kg/day d.i.v.) on its own. The regimen related toxicity was minimal, and stable engraftment was achieved. Since acute GVHD had not developed by day 30, CsA was stopped abruptly in both cases. After CsA withdrawal, acute GVHD developed, and subsequent chronic GVHD. One of two cases is alive without any relapse of the leukemia 40 months after the peripheral blood stem cell transplantation (PBSCT). In the other case, ALL relapsed 15 months after the PBSCT, however, complete remission was again induced concomitantly with reactivated GVHD. In both these cases, the results suggest that using PBSC as a stem cell source and abrupt cessation of GVHD prophylaxis provided a potent graft-versus-leukemia effect. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/16910574/[Reduced_intensity_stem_cell_transplantation_using_allogeneic_peripheral_blood_stem_cells_from_the_same_donor_for_relapsed_leukemia_after_bone_marrow_transplantation]_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/rinketsu/47.639?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -