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Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type 2 diabetes.
Pediatr Diabetes. 2006 Aug; 7(4):205-10.PD

Abstract

OBJECTIVE

The aim of this study was to evaluate whether fasting laboratory values can predict impaired glucose tolerance (IGT) in adolescents who are at risk for developing type 2 diabetes mellitus (T2DM).

HYPOTHESIS

Elevated fasting triglycerides, a marker for worsening insulin resistance, predict risk for IGT.

DESIGN

Following a fast of at least 9 h, laboratory measures, body mass index (BMI), and demographic information were obtained. The subjects then underwent a 75-g oral glucose challenge with a 2-h postchallenge glucose determination.

SUBJECTS

Eighty-four adolescents aged 12-20 yr with at least two risk factors for developing T2DM (obesity, family history of T2DM, or acanthosis nigricans) and with either a fasting insulin level > or =25 microU/mL or a homeostasis model assessment of insulin resistance (HOMA-IR) > or =3.5 were recruited for the study.

RESULTS

Ten subjects (12%) had IGT [2-h glucose > or =140 mg/dL (7.77 mmol/L)], and 10 subjects (12%) had impaired fasting glucose [IFG; fasting glucose > or =100 mg/dL (5.55 mmol/L)]. However, only three (30%) subjects with IGT had IFG, though all subjects with IGT had a fasting triglyceride level > or =150 mg/dL (1.70 mmol/L). Of those subjects with elevated triglycerides, 29% had IGT. As a screening test to predict risk for IGT, elevated triglycerides >150 mg/dL had a sensitivity of 100% and a specificity of 68%. The positive predictive value was 29%, and the negative predictive value was 100%.

CONCLUSIONS

Screening with fasting glucose alone would have missed 70% of subjects with IGT in this population of insulin-resistant adolescents. However, a fasting triglyceride level > or =150 mg/dL was strongly associated with IGT and may help to identify at-risk adolescents who should undergo formal glucose tolerance testing.

Authors+Show Affiliations

Division of Adolescent Medicine, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO, USA. kathryn.love-osborne@dhha.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16911007

Citation

Love-Osborne, Kathy, et al. "Elevated Fasting Triglycerides Predict Impaired Glucose Tolerance in Adolescents at Risk for Type 2 Diabetes." Pediatric Diabetes, vol. 7, no. 4, 2006, pp. 205-10.
Love-Osborne K, Butler N, Gao D, et al. Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type 2 diabetes. Pediatr Diabetes. 2006;7(4):205-10.
Love-Osborne, K., Butler, N., Gao, D., & Zeitler, P. (2006). Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type 2 diabetes. Pediatric Diabetes, 7(4), 205-10.
Love-Osborne K, et al. Elevated Fasting Triglycerides Predict Impaired Glucose Tolerance in Adolescents at Risk for Type 2 Diabetes. Pediatr Diabetes. 2006;7(4):205-10. PubMed PMID: 16911007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated fasting triglycerides predict impaired glucose tolerance in adolescents at risk for type 2 diabetes. AU - Love-Osborne,Kathy, AU - Butler,Nancy, AU - Gao,Dexiang, AU - Zeitler,Phil, PY - 2006/8/17/pubmed PY - 2006/12/9/medline PY - 2006/8/17/entrez SP - 205 EP - 10 JF - Pediatric diabetes JO - Pediatr Diabetes VL - 7 IS - 4 N2 - OBJECTIVE: The aim of this study was to evaluate whether fasting laboratory values can predict impaired glucose tolerance (IGT) in adolescents who are at risk for developing type 2 diabetes mellitus (T2DM). HYPOTHESIS: Elevated fasting triglycerides, a marker for worsening insulin resistance, predict risk for IGT. DESIGN: Following a fast of at least 9 h, laboratory measures, body mass index (BMI), and demographic information were obtained. The subjects then underwent a 75-g oral glucose challenge with a 2-h postchallenge glucose determination. SUBJECTS: Eighty-four adolescents aged 12-20 yr with at least two risk factors for developing T2DM (obesity, family history of T2DM, or acanthosis nigricans) and with either a fasting insulin level > or =25 microU/mL or a homeostasis model assessment of insulin resistance (HOMA-IR) > or =3.5 were recruited for the study. RESULTS: Ten subjects (12%) had IGT [2-h glucose > or =140 mg/dL (7.77 mmol/L)], and 10 subjects (12%) had impaired fasting glucose [IFG; fasting glucose > or =100 mg/dL (5.55 mmol/L)]. However, only three (30%) subjects with IGT had IFG, though all subjects with IGT had a fasting triglyceride level > or =150 mg/dL (1.70 mmol/L). Of those subjects with elevated triglycerides, 29% had IGT. As a screening test to predict risk for IGT, elevated triglycerides >150 mg/dL had a sensitivity of 100% and a specificity of 68%. The positive predictive value was 29%, and the negative predictive value was 100%. CONCLUSIONS: Screening with fasting glucose alone would have missed 70% of subjects with IGT in this population of insulin-resistant adolescents. However, a fasting triglyceride level > or =150 mg/dL was strongly associated with IGT and may help to identify at-risk adolescents who should undergo formal glucose tolerance testing. SN - 1399-543X UR - https://www.unboundmedicine.com/medline/citation/16911007/Elevated_fasting_triglycerides_predict_impaired_glucose_tolerance_in_adolescents_at_risk_for_type_2_diabetes_ L2 - https://doi.org/10.1111/j.1399-5448.2006.00179.x DB - PRIME DP - Unbound Medicine ER -