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Does lean rather than fat mass provide the link between birth weight, BMI, and metabolic risk? EarlyBird 23.
Pediatr Diabetes 2006; 7(4):211-4PD

Abstract

BACKGROUND

High birth weight predicts subsequent obesity, but paradoxically, a reduced risk of subsequent cardiovascular disease compared with low birth weight. This apparent paradox might be explained if high birth weight programmed a greater proportion of subsequent lean mass, which carries less cardiovascular risk than fat tissue.

AIM

The aim of this study was to test the hypothesis that the direct correlation between birth weight and subsequent body mass index (BMI) represents an association between birth weight and lean tissue, and to assess the metabolic impact of this relationship.

METHODS

A total of 234 healthy prepubertal children (133 boys, 101 girls, mean age 5.9 yr +/- 0.3 standard deviation) were studied. Birth weights were obtained from maternity records. Lean mass was measured by bioelectrical impedance. Anthropometric measures included height, weight (BMI), waist circumference, and subcutaneous fat mass (FM). Insulin resistance was assessed by the homeostasis model method. Metabolic correlates of insulin resistance included total and high-density lipoprotein cholesterol, triglycerides, and sex-hormone-binding globulin.

RESULTS

Birth weight correlated significantly with lean mass in boys (r = 0.41, p < 0.001) and girls (r = 0.27, p < 0.01). Adjusting for BMI did not improve the correlation further. After adjustment for FM, lean mass correlated inversely with triglycerides in boys only (r = -0.41, p < 0.01). Birth weight correlated inversely with triglycerides in boys (r = -0.18, p < 0.05); after adjustment for lean mass, this correlation was not significant.

INTERPRETATION

In boys, the relationships between birth weight, triglycerides, and lean mass are consistent with the hypothesis. Overall, our findings provide limited evidence in support of the argument that higher birth weight predicts lower metabolic risk because it marks programming of more lean mass.

Authors+Show Affiliations

Division of Pathology and Neuroscience, University of Dundee, Dundee, UK. m.j.murphy@dundee.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16911008

Citation

Murphy, Michael J., et al. "Does Lean Rather Than Fat Mass Provide the Link Between Birth Weight, BMI, and Metabolic Risk? EarlyBird 23." Pediatric Diabetes, vol. 7, no. 4, 2006, pp. 211-4.
Murphy MJ, Metcalf BS, Jeffery AN, et al. Does lean rather than fat mass provide the link between birth weight, BMI, and metabolic risk? EarlyBird 23. Pediatr Diabetes. 2006;7(4):211-4.
Murphy, M. J., Metcalf, B. S., Jeffery, A. N., Voss, L. D., & Wilkin, T. J. (2006). Does lean rather than fat mass provide the link between birth weight, BMI, and metabolic risk? EarlyBird 23. Pediatric Diabetes, 7(4), pp. 211-4.
Murphy MJ, et al. Does Lean Rather Than Fat Mass Provide the Link Between Birth Weight, BMI, and Metabolic Risk? EarlyBird 23. Pediatr Diabetes. 2006;7(4):211-4. PubMed PMID: 16911008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does lean rather than fat mass provide the link between birth weight, BMI, and metabolic risk? EarlyBird 23. AU - Murphy,Michael J, AU - Metcalf,Bradley S, AU - Jeffery,Alison N, AU - Voss,Linda D, AU - Wilkin,Terence J, PY - 2006/8/17/pubmed PY - 2006/12/9/medline PY - 2006/8/17/entrez SP - 211 EP - 4 JF - Pediatric diabetes JO - Pediatr Diabetes VL - 7 IS - 4 N2 - BACKGROUND: High birth weight predicts subsequent obesity, but paradoxically, a reduced risk of subsequent cardiovascular disease compared with low birth weight. This apparent paradox might be explained if high birth weight programmed a greater proportion of subsequent lean mass, which carries less cardiovascular risk than fat tissue. AIM: The aim of this study was to test the hypothesis that the direct correlation between birth weight and subsequent body mass index (BMI) represents an association between birth weight and lean tissue, and to assess the metabolic impact of this relationship. METHODS: A total of 234 healthy prepubertal children (133 boys, 101 girls, mean age 5.9 yr +/- 0.3 standard deviation) were studied. Birth weights were obtained from maternity records. Lean mass was measured by bioelectrical impedance. Anthropometric measures included height, weight (BMI), waist circumference, and subcutaneous fat mass (FM). Insulin resistance was assessed by the homeostasis model method. Metabolic correlates of insulin resistance included total and high-density lipoprotein cholesterol, triglycerides, and sex-hormone-binding globulin. RESULTS: Birth weight correlated significantly with lean mass in boys (r = 0.41, p < 0.001) and girls (r = 0.27, p < 0.01). Adjusting for BMI did not improve the correlation further. After adjustment for FM, lean mass correlated inversely with triglycerides in boys only (r = -0.41, p < 0.01). Birth weight correlated inversely with triglycerides in boys (r = -0.18, p < 0.05); after adjustment for lean mass, this correlation was not significant. INTERPRETATION: In boys, the relationships between birth weight, triglycerides, and lean mass are consistent with the hypothesis. Overall, our findings provide limited evidence in support of the argument that higher birth weight predicts lower metabolic risk because it marks programming of more lean mass. SN - 1399-543X UR - https://www.unboundmedicine.com/medline/citation/16911008/Does_lean_rather_than_fat_mass_provide_the_link_between_birth_weight_BMI_and_metabolic_risk_EarlyBird_23_ L2 - https://doi.org/10.1111/j.1399-5448.2006.00180.x DB - PRIME DP - Unbound Medicine ER -