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Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute pain relief after third molar surgery: a randomized, double-blind, placebo-controlled study.
Eur J Oral Sci 2006; 114(4):293-301EJ

Abstract

Severe pain after third molar surgery is often encountered and more effective treatment regimes are warranted. The objective of this study was to evaluate if the combination of paracetamol and rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, improves analgesic effects following third molar surgery compared with rofecoxib alone. Paracetamol alone was also evaluated. Altogether 120 patients with moderate to severe pain after third molar surgery were given a single postoperative dose of one of the following treatments: rofecoxib + paracetamol; rofecoxib alone; paracetamol alone; or placebo. Patients assessed level of pain and pain relief every 30 min for 8 h after surgery, and made a global evaluation of the medication 4 and 8 h after surgery. Paracetamol and rofecoxib combined improved the analgesic effect compared with rofecoxib alone for the first 1.5 h. Rofecoxib alone and the combination of paracetamol and rofecoxib had a significantly better analgesic effect than paracetamol alone from 3 h onwards. The early onset of pain relief for the combination of paracetamol and rofecoxib, compared with rofecoxib alone, could be of great importance when treating acute pain after third molar surgery. After data collection for this study, rofecoxib was withdrawn from the market as a result of reported fatal cardiovascular events. Whether this is relevant for short-term use is unknown, but it has to be considered before rofecoxib may be used for pain relief following third molar surgery.

Authors+Show Affiliations

Public Dental Health Service, Karlstad, Värmland, Sweden. birgitta.haglund@liv.seNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16911100

Citation

Haglund, Birgitta, and Inger von Bültzingslöwen. "Combining Paracetamol With a Selective Cyclooxygenase-2 Inhibitor for Acute Pain Relief After Third Molar Surgery: a Randomized, Double-blind, Placebo-controlled Study." European Journal of Oral Sciences, vol. 114, no. 4, 2006, pp. 293-301.
Haglund B, von Bültzingslöwen I. Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute pain relief after third molar surgery: a randomized, double-blind, placebo-controlled study. Eur J Oral Sci. 2006;114(4):293-301.
Haglund, B., & von Bültzingslöwen, I. (2006). Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute pain relief after third molar surgery: a randomized, double-blind, placebo-controlled study. European Journal of Oral Sciences, 114(4), pp. 293-301.
Haglund B, von Bültzingslöwen I. Combining Paracetamol With a Selective Cyclooxygenase-2 Inhibitor for Acute Pain Relief After Third Molar Surgery: a Randomized, Double-blind, Placebo-controlled Study. Eur J Oral Sci. 2006;114(4):293-301. PubMed PMID: 16911100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute pain relief after third molar surgery: a randomized, double-blind, placebo-controlled study. AU - Haglund,Birgitta, AU - von Bültzingslöwen,Inger, PY - 2006/8/17/pubmed PY - 2006/10/21/medline PY - 2006/8/17/entrez SP - 293 EP - 301 JF - European journal of oral sciences JO - Eur. J. Oral Sci. VL - 114 IS - 4 N2 - Severe pain after third molar surgery is often encountered and more effective treatment regimes are warranted. The objective of this study was to evaluate if the combination of paracetamol and rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, improves analgesic effects following third molar surgery compared with rofecoxib alone. Paracetamol alone was also evaluated. Altogether 120 patients with moderate to severe pain after third molar surgery were given a single postoperative dose of one of the following treatments: rofecoxib + paracetamol; rofecoxib alone; paracetamol alone; or placebo. Patients assessed level of pain and pain relief every 30 min for 8 h after surgery, and made a global evaluation of the medication 4 and 8 h after surgery. Paracetamol and rofecoxib combined improved the analgesic effect compared with rofecoxib alone for the first 1.5 h. Rofecoxib alone and the combination of paracetamol and rofecoxib had a significantly better analgesic effect than paracetamol alone from 3 h onwards. The early onset of pain relief for the combination of paracetamol and rofecoxib, compared with rofecoxib alone, could be of great importance when treating acute pain after third molar surgery. After data collection for this study, rofecoxib was withdrawn from the market as a result of reported fatal cardiovascular events. Whether this is relevant for short-term use is unknown, but it has to be considered before rofecoxib may be used for pain relief following third molar surgery. SN - 0909-8836 UR - https://www.unboundmedicine.com/medline/citation/16911100/Combining_paracetamol_with_a_selective_cyclooxygenase_2_inhibitor_for_acute_pain_relief_after_third_molar_surgery:_a_randomized_double_blind_placebo_controlled_study_ L2 - https://doi.org/10.1111/j.1600-0722.2006.00365.x DB - PRIME DP - Unbound Medicine ER -