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Value of B-type natriuretic peptide in diagnosing left ventricular dysfunction in dialysis-dependent patients.
Intern Med J. 2006 Sep; 36(9):552-7.IM

Abstract

BACKGROUND

B-type natriuretic peptide (BNP) is elevated in patients with end-stage renal failure. The reported accuracy of BNP in diagnosing left ventricular dysfunction in these patients has been inconsistent.

AIM

To investigate the diagnostic values of BNP for left ventricular dysfunction in patients undergoing haemodialysis for chronic renal failure.

METHODS

We measured plasma BNP before and at 10 min and 3, 6 and 24 h after haemodialysis in 56 patients.

RESULTS

The average plasma BNP before haemodialysis was 284 +/- 369 pg/mL, which was higher than that of healthy subjects (37 +/- 37 pg/mL; n = 32, P < 0.01). The average plasma BNP in patients with left ventricular dysfunction (n = 21) was substantially higher than that in those with normal ventricular function before and at 10 min and 3, 6 and 24 h after haemodialysis (P < 0.001). The area under the receiver operating characteristic curves was greater than 0.895 before and at the four time points after haemodialysis (P < 0.01). Using 152 pg/mL as a cut-off value, predialysis BNP has 81% sensitivity and 83% specificity in diagnosing left ventricular dysfunction in these patients.

CONCLUSION

We concluded that plasma BNP offers a good sensitivity and specificity in diagnosing left ventricular dysfunction in patients with dialysis-dependent renal failure.

Authors+Show Affiliations

Department of Cardiology, Lishui City Central Hospital, Zhejiang Province, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16911545

Citation

Zeng, C, et al. "Value of B-type Natriuretic Peptide in Diagnosing Left Ventricular Dysfunction in Dialysis-dependent Patients." Internal Medicine Journal, vol. 36, no. 9, 2006, pp. 552-7.
Zeng C, Wei T, Jin L, et al. Value of B-type natriuretic peptide in diagnosing left ventricular dysfunction in dialysis-dependent patients. Intern Med J. 2006;36(9):552-7.
Zeng, C., Wei, T., Jin, L., & Wang, L. (2006). Value of B-type natriuretic peptide in diagnosing left ventricular dysfunction in dialysis-dependent patients. Internal Medicine Journal, 36(9), 552-7.
Zeng C, et al. Value of B-type Natriuretic Peptide in Diagnosing Left Ventricular Dysfunction in Dialysis-dependent Patients. Intern Med J. 2006;36(9):552-7. PubMed PMID: 16911545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of B-type natriuretic peptide in diagnosing left ventricular dysfunction in dialysis-dependent patients. AU - Zeng,C, AU - Wei,T, AU - Jin,L, AU - Wang,L, PY - 2006/8/17/pubmed PY - 2006/9/28/medline PY - 2006/8/17/entrez SP - 552 EP - 7 JF - Internal medicine journal JO - Intern Med J VL - 36 IS - 9 N2 - BACKGROUND: B-type natriuretic peptide (BNP) is elevated in patients with end-stage renal failure. The reported accuracy of BNP in diagnosing left ventricular dysfunction in these patients has been inconsistent. AIM: To investigate the diagnostic values of BNP for left ventricular dysfunction in patients undergoing haemodialysis for chronic renal failure. METHODS: We measured plasma BNP before and at 10 min and 3, 6 and 24 h after haemodialysis in 56 patients. RESULTS: The average plasma BNP before haemodialysis was 284 +/- 369 pg/mL, which was higher than that of healthy subjects (37 +/- 37 pg/mL; n = 32, P < 0.01). The average plasma BNP in patients with left ventricular dysfunction (n = 21) was substantially higher than that in those with normal ventricular function before and at 10 min and 3, 6 and 24 h after haemodialysis (P < 0.001). The area under the receiver operating characteristic curves was greater than 0.895 before and at the four time points after haemodialysis (P < 0.01). Using 152 pg/mL as a cut-off value, predialysis BNP has 81% sensitivity and 83% specificity in diagnosing left ventricular dysfunction in these patients. CONCLUSION: We concluded that plasma BNP offers a good sensitivity and specificity in diagnosing left ventricular dysfunction in patients with dialysis-dependent renal failure. SN - 1445-5994 UR - https://www.unboundmedicine.com/medline/citation/16911545/Value_of_B_type_natriuretic_peptide_in_diagnosing_left_ventricular_dysfunction_in_dialysis_dependent_patients_ L2 - https://doi.org/10.1111/j.1445-5994.2006.01136.x DB - PRIME DP - Unbound Medicine ER -