Tags

Type your tag names separated by a space and hit enter

Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa.
Am J Physiol Endocrinol Metab 2007; 292(1):E132-7AJ

Abstract

Constitutional thinness (CT) is characterized by a low and stable body mass index (BMI) without any hormonal abnormality. To understand the weight steadiness, energetic metabolism was evaluated. Seven CT, seven controls, and six anorexia nervosa (AN) young women were compared. CT and AN had a BMI <16.5 kg/m(2). Four criteria were evaluated: 1) energy balance including diet record, resting metabolic rate (RMR) (indirect calorimetry), total energy expenditure (TEE) (doubly labeled water), physical activity; 2) body composition (dual-energy X-ray absorptiometry); 3) biological markers (leptin, IGF-I, free T3); 4) psychological profile of eating behavior. The normality of free T3 (3.7 +/- 0.5 pmol/l), IGF-I (225 +/- 93 ng/ml), and leptin (8.3 +/- 3.4 ng/ml) confirmed the absence of undernutrition in CT. Their psychological profiles revealed a weight gain desire. TEE (kJ/day) in CT (8,382 +/- 988) was not found significantly different from that of controls (8,793 +/- 845) and AN (8,001 +/- 2,152). CT food intake (7,565 +/- 908 kJ/day) was found similar to that of controls (7,961 +/- 1,452 kJ/day) and higher than in AN (4,894 +/- 703 kJ/day), thus explaining the energy metabolism balance. Fat-free mass (FFM) (kg) was similar in CT and AN (32.5 +/- 2.9 vs. 34.1 +/- 1.9) and higher in controls (37.8 +/- 1.6). While RMR absolute values (kJ/day) were lower in CT (4,839 +/- 473) than in controls (5,576 +/- 209), RMR values adjusted for FFM were the highest in CT. TEE-to-FFM ratio was also higher in CT than in controls. Energetic metabolism balance maintains a stable low weight in CT. An increased energy expenditure-to-FFM ratio differentiates CT from controls and could account for the resistance to weight gain observed in CT.

Authors+Show Affiliations

Service d'endocrinologie diabète et maladies métaboliques, Hôpital Bellevue, CHU Saint Etienne, 42055 Saint Etienne Cedex 02, France. bruno.estour@chu-st-etienne.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16912058

Citation

Bossu, Cécile, et al. "Energy Expenditure Adjusted for Body Composition Differentiates Constitutional Thinness From Both Normal Subjects and Anorexia Nervosa." American Journal of Physiology. Endocrinology and Metabolism, vol. 292, no. 1, 2007, pp. E132-7.
Bossu C, Galusca B, Normand S, et al. Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa. Am J Physiol Endocrinol Metab. 2007;292(1):E132-7.
Bossu, C., Galusca, B., Normand, S., Germain, N., Collet, P., Frere, D., ... Estour, B. (2007). Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa. American Journal of Physiology. Endocrinology and Metabolism, 292(1), pp. E132-7.
Bossu C, et al. Energy Expenditure Adjusted for Body Composition Differentiates Constitutional Thinness From Both Normal Subjects and Anorexia Nervosa. Am J Physiol Endocrinol Metab. 2007;292(1):E132-7. PubMed PMID: 16912058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa. AU - Bossu,Cécile, AU - Galusca,Bogdan, AU - Normand,Sylvie, AU - Germain,Natacha, AU - Collet,Philippe, AU - Frere,Delphine, AU - Lang,François, AU - Laville,Martine, AU - Estour,Bruno, Y1 - 2006/08/15/ PY - 2006/8/17/pubmed PY - 2007/2/17/medline PY - 2006/8/17/entrez SP - E132 EP - 7 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 292 IS - 1 N2 - Constitutional thinness (CT) is characterized by a low and stable body mass index (BMI) without any hormonal abnormality. To understand the weight steadiness, energetic metabolism was evaluated. Seven CT, seven controls, and six anorexia nervosa (AN) young women were compared. CT and AN had a BMI <16.5 kg/m(2). Four criteria were evaluated: 1) energy balance including diet record, resting metabolic rate (RMR) (indirect calorimetry), total energy expenditure (TEE) (doubly labeled water), physical activity; 2) body composition (dual-energy X-ray absorptiometry); 3) biological markers (leptin, IGF-I, free T3); 4) psychological profile of eating behavior. The normality of free T3 (3.7 +/- 0.5 pmol/l), IGF-I (225 +/- 93 ng/ml), and leptin (8.3 +/- 3.4 ng/ml) confirmed the absence of undernutrition in CT. Their psychological profiles revealed a weight gain desire. TEE (kJ/day) in CT (8,382 +/- 988) was not found significantly different from that of controls (8,793 +/- 845) and AN (8,001 +/- 2,152). CT food intake (7,565 +/- 908 kJ/day) was found similar to that of controls (7,961 +/- 1,452 kJ/day) and higher than in AN (4,894 +/- 703 kJ/day), thus explaining the energy metabolism balance. Fat-free mass (FFM) (kg) was similar in CT and AN (32.5 +/- 2.9 vs. 34.1 +/- 1.9) and higher in controls (37.8 +/- 1.6). While RMR absolute values (kJ/day) were lower in CT (4,839 +/- 473) than in controls (5,576 +/- 209), RMR values adjusted for FFM were the highest in CT. TEE-to-FFM ratio was also higher in CT than in controls. Energetic metabolism balance maintains a stable low weight in CT. An increased energy expenditure-to-FFM ratio differentiates CT from controls and could account for the resistance to weight gain observed in CT. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/16912058/Energy_expenditure_adjusted_for_body_composition_differentiates_constitutional_thinness_from_both_normal_subjects_and_anorexia_nervosa_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.00241.2006?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -