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Non-alcoholic steatohepatitis and metabolic syndrome.
Curr Opin Clin Nutr Metab Care. 2006 Sep; 9(5):637-42.CO

Abstract

PURPOSE OF REVIEW

Non-alcoholic steatohepatitis is part of a disease spectrum, non-alcoholic fatty liver disease, ranging from simple steatosis to cirrhosis, which is the most frequent cause of abnormal liver tests. There is clinical and epidemiological evidence that non-alcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome, having in common insulin resistance.

RECENT FINDINGS

The interest in the metabolic syndrome concept has been questioned. Insulin resistance, oxidative stress, mitochondrial dysfunction, immune deregulation and adipokines seem to be crucial in the pathogenesis of non-alcoholic fatty liver disease. The main treatment continues to rely on lifestyle changes, including weight loss strategies. Bariatric surgery in morbidly obese patients and insulin-sensitizing agents seem to be beneficial.

SUMMARY

There is strong evidence of the association of non-alcoholic steatohepatitis with the features of the metabolic syndrome, with its increased cardiovascular risk. Population interventions in order to change lifestyles and diet patterns that constitute risk factors for both situations are urgently needed. There is, however, evidence that in the presence of other risk factors, insulin resistance may be less important. These secondary forms of non-alcoholic steatohepatitis must be recognized, as they are potentially treatable by withdrawing the steatogenic factor.

Authors+Show Affiliations

Unidade de Nutrição e Metabolismo, Departamento de Gastrenterologia, Instituto de Medicina Molecular, Hospital de Santa Maria, Lisbon, Portugal.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16912563

Citation

Machado, Mariana, and Helena Cortez-Pinto. "Non-alcoholic Steatohepatitis and Metabolic Syndrome." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 9, no. 5, 2006, pp. 637-42.
Machado M, Cortez-Pinto H. Non-alcoholic steatohepatitis and metabolic syndrome. Curr Opin Clin Nutr Metab Care. 2006;9(5):637-42.
Machado, M., & Cortez-Pinto, H. (2006). Non-alcoholic steatohepatitis and metabolic syndrome. Current Opinion in Clinical Nutrition and Metabolic Care, 9(5), 637-42.
Machado M, Cortez-Pinto H. Non-alcoholic Steatohepatitis and Metabolic Syndrome. Curr Opin Clin Nutr Metab Care. 2006;9(5):637-42. PubMed PMID: 16912563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-alcoholic steatohepatitis and metabolic syndrome. AU - Machado,Mariana, AU - Cortez-Pinto,Helena, PY - 2006/8/17/pubmed PY - 2006/10/17/medline PY - 2006/8/17/entrez SP - 637 EP - 42 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 9 IS - 5 N2 - PURPOSE OF REVIEW: Non-alcoholic steatohepatitis is part of a disease spectrum, non-alcoholic fatty liver disease, ranging from simple steatosis to cirrhosis, which is the most frequent cause of abnormal liver tests. There is clinical and epidemiological evidence that non-alcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome, having in common insulin resistance. RECENT FINDINGS: The interest in the metabolic syndrome concept has been questioned. Insulin resistance, oxidative stress, mitochondrial dysfunction, immune deregulation and adipokines seem to be crucial in the pathogenesis of non-alcoholic fatty liver disease. The main treatment continues to rely on lifestyle changes, including weight loss strategies. Bariatric surgery in morbidly obese patients and insulin-sensitizing agents seem to be beneficial. SUMMARY: There is strong evidence of the association of non-alcoholic steatohepatitis with the features of the metabolic syndrome, with its increased cardiovascular risk. Population interventions in order to change lifestyles and diet patterns that constitute risk factors for both situations are urgently needed. There is, however, evidence that in the presence of other risk factors, insulin resistance may be less important. These secondary forms of non-alcoholic steatohepatitis must be recognized, as they are potentially treatable by withdrawing the steatogenic factor. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/16912563/Non_alcoholic_steatohepatitis_and_metabolic_syndrome_ L2 - https://doi.org/10.1097/01.mco.0000241677.40170.17 DB - PRIME DP - Unbound Medicine ER -