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Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats.
Food Chem Toxicol 2006; 44(12):1989-96FC

Abstract

This study was undertaken to investigate the putative antioxidant activity of the oyster mushroom Pleurotus ostreatus on CCl(4)-induced liver damage in male Wistar rats. Intraperitoneal administration of CCl(4) (2ml/kg) to rats for 4 days resulted in significantly elevated (p<0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT) and alkaline phosphatase (SALP) compared to controls. In the liver, significantly elevated levels (p<0.05) of malondialdehyde (MDA) and lowered levels (p<0.05) of reduced glutathione (GSH) were observed following CCl(4) administration. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (Gpx) revealed lower activities of these antioxidant enzymes in the liver of CCl(4)-administered rats. An analysis of the isozyme pattern of these enzymes revealed variations in relative concentration presumably due to hepatotoxicity. When rats with CCl(4)-induced hepatotoxicity were treated with the extract of P. ostreatus, the serum SGOT, SGPT and SALP levels reverted to near normal, while the hepatic concentration of GSH, CAT, SOD and Gpx were significantly increased (p<0.05) and that of MDA significantly (p<0.05) lowered, when compared to CCl(4)-exposed untreated rats. Histopathological studies confirmed the hepatoprotective effect conferred by the extract of P. ostreatus. These results suggest that an extract of P. ostreatus is able to significantly alleviate the hepatotoxicity induced by CCl(4) in the rat.

Authors+Show Affiliations

Department of Animal Science, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16914248

Citation

Jayakumar, T, et al. "Antioxidant Activity of the Oyster Mushroom, Pleurotus Ostreatus, On CCl(4)-induced Liver Injury in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 44, no. 12, 2006, pp. 1989-96.
Jayakumar T, Ramesh E, Geraldine P. Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats. Food Chem Toxicol. 2006;44(12):1989-96.
Jayakumar, T., Ramesh, E., & Geraldine, P. (2006). Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 44(12), pp. 1989-96.
Jayakumar T, Ramesh E, Geraldine P. Antioxidant Activity of the Oyster Mushroom, Pleurotus Ostreatus, On CCl(4)-induced Liver Injury in Rats. Food Chem Toxicol. 2006;44(12):1989-96. PubMed PMID: 16914248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl(4)-induced liver injury in rats. AU - Jayakumar,T, AU - Ramesh,E, AU - Geraldine,P, Y1 - 2006/07/12/ PY - 2005/08/29/received PY - 2006/06/17/revised PY - 2006/06/26/accepted PY - 2006/8/18/pubmed PY - 2006/12/15/medline PY - 2006/8/18/entrez SP - 1989 EP - 96 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 44 IS - 12 N2 - This study was undertaken to investigate the putative antioxidant activity of the oyster mushroom Pleurotus ostreatus on CCl(4)-induced liver damage in male Wistar rats. Intraperitoneal administration of CCl(4) (2ml/kg) to rats for 4 days resulted in significantly elevated (p<0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT) and alkaline phosphatase (SALP) compared to controls. In the liver, significantly elevated levels (p<0.05) of malondialdehyde (MDA) and lowered levels (p<0.05) of reduced glutathione (GSH) were observed following CCl(4) administration. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (Gpx) revealed lower activities of these antioxidant enzymes in the liver of CCl(4)-administered rats. An analysis of the isozyme pattern of these enzymes revealed variations in relative concentration presumably due to hepatotoxicity. When rats with CCl(4)-induced hepatotoxicity were treated with the extract of P. ostreatus, the serum SGOT, SGPT and SALP levels reverted to near normal, while the hepatic concentration of GSH, CAT, SOD and Gpx were significantly increased (p<0.05) and that of MDA significantly (p<0.05) lowered, when compared to CCl(4)-exposed untreated rats. Histopathological studies confirmed the hepatoprotective effect conferred by the extract of P. ostreatus. These results suggest that an extract of P. ostreatus is able to significantly alleviate the hepatotoxicity induced by CCl(4) in the rat. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/16914248/Antioxidant_activity_of_the_oyster_mushroom_Pleurotus_ostreatus_on_CCl_4__induced_liver_injury_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(06)00180-3 DB - PRIME DP - Unbound Medicine ER -