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Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania.

Abstract

Pharmacological studies suggest that neurotrophins may play a role in the effects of lithium and valproate on mood regulation. In this study, we tested the hypotheses that lithium and valproate would reverse and prevent the behavioral and biochemical effects of amphetamine, using a rat model of mania. In the reversal treatment, male Wistar rats were first administered D-amphetamine or saline for 14 days, and then, between days 8-14, rats were treated with lithium, valproate or saline. In the prevention treatment, rats were pretreated with lithium, valproate or saline, and then, between days 8-14, rats were administered D-amphetamine or saline. Locomotor behavior was assessed using the open-field task and hippocampal nerve growth factor levels were determined by enzyme-linked immunosorbent assay. Both lithium and valproate reversed and prevented D-amphetamine-induced hyperactivity. Lithium increased nerve growth factor content in rat hippocampus in both experiments, but this effect was blocked with the co-administration of D-amphetamine. No significant effects on nerve growth factor levels were observed with valproate or D-amphetamine alone. These findings suggest that nerve growth factor may play a role in the neurotrophic effects of lithium but do not support the hypotheses that the nerve growth factor/TrkA pathway is involved in the pathophysiology of bipolar disorder.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

    , , , , , , ,

    Source

    Behavioural pharmacology 17:4 2006 Jun pg 311-8

    MeSH

    Amphetamine
    Animals
    Antimanic Agents
    Bipolar Disorder
    Central Nervous System Stimulants
    Hippocampus
    Lithium
    Male
    Motor Activity
    Nerve Growth Factors
    Rats
    Rats, Wistar
    Valproic Acid

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16914949

    Citation

    Frey, Benício N., et al. "Lithium Increases Nerve Growth Factor Levels in the Rat Hippocampus in an Animal Model of Mania." Behavioural Pharmacology, vol. 17, no. 4, 2006, pp. 311-8.
    Frey BN, Andreazza AC, Rosa AR, et al. Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania. Behav Pharmacol. 2006;17(4):311-8.
    Frey, B. N., Andreazza, A. C., Rosa, A. R., Martins, M. R., Valvassori, S. S., Réus, G. Z., ... Kapczinski, F. (2006). Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania. Behavioural Pharmacology, 17(4), pp. 311-8.
    Frey BN, et al. Lithium Increases Nerve Growth Factor Levels in the Rat Hippocampus in an Animal Model of Mania. Behav Pharmacol. 2006;17(4):311-8. PubMed PMID: 16914949.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania. AU - Frey,Benício N, AU - Andreazza,Ana C, AU - Rosa,Adriane R, AU - Martins,Márcio R, AU - Valvassori,Samira S, AU - Réus,Gislaine Z, AU - Hatch,John P, AU - Quevedo,João, AU - Kapczinski,Flávio, PY - 2006/8/18/pubmed PY - 2006/9/16/medline PY - 2006/8/18/entrez SP - 311 EP - 8 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 17 IS - 4 N2 - Pharmacological studies suggest that neurotrophins may play a role in the effects of lithium and valproate on mood regulation. In this study, we tested the hypotheses that lithium and valproate would reverse and prevent the behavioral and biochemical effects of amphetamine, using a rat model of mania. In the reversal treatment, male Wistar rats were first administered D-amphetamine or saline for 14 days, and then, between days 8-14, rats were treated with lithium, valproate or saline. In the prevention treatment, rats were pretreated with lithium, valproate or saline, and then, between days 8-14, rats were administered D-amphetamine or saline. Locomotor behavior was assessed using the open-field task and hippocampal nerve growth factor levels were determined by enzyme-linked immunosorbent assay. Both lithium and valproate reversed and prevented D-amphetamine-induced hyperactivity. Lithium increased nerve growth factor content in rat hippocampus in both experiments, but this effect was blocked with the co-administration of D-amphetamine. No significant effects on nerve growth factor levels were observed with valproate or D-amphetamine alone. These findings suggest that nerve growth factor may play a role in the neurotrophic effects of lithium but do not support the hypotheses that the nerve growth factor/TrkA pathway is involved in the pathophysiology of bipolar disorder. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/16914949/Lithium_increases_nerve_growth_factor_levels_in_the_rat_hippocampus_in_an_animal_model_of_mania_ L2 - http://Insights.ovid.com/pubmed?pmid=16914949 DB - PRIME DP - Unbound Medicine ER -