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HLA DQA1*0501 and DQB1*02 in Cuban celiac patients.
Hum Immunol. 2006 Aug; 67(8):639-42.HI

Abstract

Celiac disease (CD) susceptibility has been strongly associated with HLA-DQ2 and HLA-DQ8. The main objective of this study was to assess the distribution of HLA DQA1*0501 and DQB1*02 alleles (DQ2) for the first time in a group of Cuban celiac patients. We evaluated 22 patients, 54 first-degree relatives, and 60 controls for detection of antitissue transglutaminase (tTG)-specific antibodies in serum. We found that 100% of the probands and 19% of the first-degree relatives were positive for the antibodies in serum. We did not detect any specific response for the healthy control individuals. We observed a significant over-representation of DQ2 heterodimer, both in patients and relatives. In the group of patients, 86.3% were positive for DQA1*0501, 90.2% were positive for DQB1*02, and 86.3% were positive for both alleles. The frequencies in relatives and controls were as follows: 70%, 90%, and 70%; and 56.6%, 45%, and 20%, respectively. In conclusion, we found that the proportion of our celiac patients carrying DQ2 was similar to the proportion of CD patients reported in populations with different genetic backgrounds. These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease.

Authors+Show Affiliations

Department of Immunotechnology and Genomics, Center for Genetic Engineering and Biotechnology, Havana, Cuba.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16916661

Citation

Cintado, Alberto, et al. "HLA DQA1*0501 and DQB1*02 in Cuban Celiac Patients." Human Immunology, vol. 67, no. 8, 2006, pp. 639-42.
Cintado A, Sorell L, Galván JA, et al. HLA DQA1*0501 and DQB1*02 in Cuban celiac patients. Hum Immunol. 2006;67(8):639-42.
Cintado, A., Sorell, L., Galván, J. A., Martínez, L., Castañeda, C., Fragoso, T., Camacho, H., Ferrer, A., Companioni, O., Benitez, J., Nazábal, M., Novoa, L. I., & Dueñas, M. (2006). HLA DQA1*0501 and DQB1*02 in Cuban celiac patients. Human Immunology, 67(8), 639-42.
Cintado A, et al. HLA DQA1*0501 and DQB1*02 in Cuban Celiac Patients. Hum Immunol. 2006;67(8):639-42. PubMed PMID: 16916661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA DQA1*0501 and DQB1*02 in Cuban celiac patients. AU - Cintado,Alberto, AU - Sorell,Luis, AU - Galván,José A, AU - Martínez,Luis, AU - Castañeda,Carlos, AU - Fragoso,Trini, AU - Camacho,Hamlet, AU - Ferrer,Annia, AU - Companioni,Osmel, AU - Benitez,Jesús, AU - Nazábal,Marcelo, AU - Novoa,Lidia I, AU - Dueñas,Marta, Y1 - 2006/05/22/ PY - 2005/10/27/received PY - 2006/8/19/pubmed PY - 2006/12/23/medline PY - 2006/8/19/entrez SP - 639 EP - 42 JF - Human immunology JO - Hum. Immunol. VL - 67 IS - 8 N2 - Celiac disease (CD) susceptibility has been strongly associated with HLA-DQ2 and HLA-DQ8. The main objective of this study was to assess the distribution of HLA DQA1*0501 and DQB1*02 alleles (DQ2) for the first time in a group of Cuban celiac patients. We evaluated 22 patients, 54 first-degree relatives, and 60 controls for detection of antitissue transglutaminase (tTG)-specific antibodies in serum. We found that 100% of the probands and 19% of the first-degree relatives were positive for the antibodies in serum. We did not detect any specific response for the healthy control individuals. We observed a significant over-representation of DQ2 heterodimer, both in patients and relatives. In the group of patients, 86.3% were positive for DQA1*0501, 90.2% were positive for DQB1*02, and 86.3% were positive for both alleles. The frequencies in relatives and controls were as follows: 70%, 90%, and 70%; and 56.6%, 45%, and 20%, respectively. In conclusion, we found that the proportion of our celiac patients carrying DQ2 was similar to the proportion of CD patients reported in populations with different genetic backgrounds. These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease. SN - 0198-8859 UR - https://www.unboundmedicine.com/medline/citation/16916661/HLA_DQA1_0501_and_DQB1_02_in_Cuban_celiac_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(06)00108-X DB - PRIME DP - Unbound Medicine ER -