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Recognizing depression in patients with Parkinson's disease: accuracy and specificity of two depression rating scale.
Arq Neuropsiquiatr. 2006 Jun; 64(2B):407-11.AN

Abstract

This study aimed to find cut-off scores for the Montgomery-Asberg rating scale (MADRS) and the Beck depression inventory (BDI) that can relate to specific clinical diagnoses of depression in Parkinson s disease (PD). Mild and moderate PD patients (n=46) were evaluated for depression according to the DSM IV criteria. All patients were assessed with the MADRS and the BDI. A "receiver operating characteristics" (ROC) curve was obtained and the sensibility, specificity, positive and the negative predictive values were calculated for different cut-off scores of the MADRS and the BDI. The Kappa statistic was calculated for different cut-off scores to assess the agreement between the clinical judgment and both scales. Depression was present in 18 patients. MADRS cut-off scores of 6 and 10 showed Kappa 0.5 and 0.56, respectively. Specificity of cut-off score of 6 was 78.6% and of cut-off score of 10 was 96.4%. Kappa agreement of BDI cut-off scores of 10 and 18 were 0.36 and 0.62, respectively. Specificity was 60.7% for 10 and 92.9% for 18. Both rating scales show similar accuracy within the ROC curves (84.3% for MADRS and 79.7% for BDI). The MADRS and the BDI show a good accuracy and correlation to the clinical diagnosis when a cut-off score of 10 is used to MADRS and a cut-off score of 18 is used to BDI to recognize depression in mild to moderate PD patients. This may help clinicians to recognize depression in PD.

Authors+Show Affiliations

Center for Alzheimer's Disease in Related Disorders, Institute of Psychiatry, Federal University of Rio de Janeiro, Rua Barata Ribeiro 774/407, 22051-000 Rio de Janeiro RJ, Brazil. cdsil@terra.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16917610

Citation

Silberman, Cláudia Débora, et al. "Recognizing Depression in Patients With Parkinson's Disease: Accuracy and Specificity of Two Depression Rating Scale." Arquivos De Neuro-psiquiatria, vol. 64, no. 2B, 2006, pp. 407-11.
Silberman CD, Laks J, Capitão CF, et al. Recognizing depression in patients with Parkinson's disease: accuracy and specificity of two depression rating scale. Arq Neuropsiquiatr. 2006;64(2B):407-11.
Silberman, C. D., Laks, J., Capitão, C. F., Rodrigues, C. S., Moreira, I., & Engelhardt, E. (2006). Recognizing depression in patients with Parkinson's disease: accuracy and specificity of two depression rating scale. Arquivos De Neuro-psiquiatria, 64(2B), 407-11.
Silberman CD, et al. Recognizing Depression in Patients With Parkinson's Disease: Accuracy and Specificity of Two Depression Rating Scale. Arq Neuropsiquiatr. 2006;64(2B):407-11. PubMed PMID: 16917610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recognizing depression in patients with Parkinson's disease: accuracy and specificity of two depression rating scale. AU - Silberman,Cláudia Débora, AU - Laks,Jerson, AU - Capitão,Cláudia Figueiredo, AU - Rodrigues,Cláudia Soares, AU - Moreira,Irene, AU - Engelhardt,Eliasz, PY - 2005/09/21/received PY - 2006/02/09/accepted PY - 2006/8/19/pubmed PY - 2007/3/23/medline PY - 2006/8/19/entrez SP - 407 EP - 11 JF - Arquivos de neuro-psiquiatria JO - Arq Neuropsiquiatr VL - 64 IS - 2B N2 - This study aimed to find cut-off scores for the Montgomery-Asberg rating scale (MADRS) and the Beck depression inventory (BDI) that can relate to specific clinical diagnoses of depression in Parkinson s disease (PD). Mild and moderate PD patients (n=46) were evaluated for depression according to the DSM IV criteria. All patients were assessed with the MADRS and the BDI. A "receiver operating characteristics" (ROC) curve was obtained and the sensibility, specificity, positive and the negative predictive values were calculated for different cut-off scores of the MADRS and the BDI. The Kappa statistic was calculated for different cut-off scores to assess the agreement between the clinical judgment and both scales. Depression was present in 18 patients. MADRS cut-off scores of 6 and 10 showed Kappa 0.5 and 0.56, respectively. Specificity of cut-off score of 6 was 78.6% and of cut-off score of 10 was 96.4%. Kappa agreement of BDI cut-off scores of 10 and 18 were 0.36 and 0.62, respectively. Specificity was 60.7% for 10 and 92.9% for 18. Both rating scales show similar accuracy within the ROC curves (84.3% for MADRS and 79.7% for BDI). The MADRS and the BDI show a good accuracy and correlation to the clinical diagnosis when a cut-off score of 10 is used to MADRS and a cut-off score of 18 is used to BDI to recognize depression in mild to moderate PD patients. This may help clinicians to recognize depression in PD. SN - 0004-282X UR - https://www.unboundmedicine.com/medline/citation/16917610/Recognizing_depression_in_patients_with_Parkinson's_disease:_accuracy_and_specificity_of_two_depression_rating_scale_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000300011&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -